Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
First Claim
1. An aqueous liquid solution formulation comprising a therapeutically effective amount of corticosteroid dissolved therein, a sulfoalkyl ether cyclodextrin (SAE-CD), and an aqueous liquid carrier, whereini. the corticosteroid is budesonide;
- ii. the sulfoalkyl ether cyclodextrin has the structure;
3 Assignments
0 Petitions
Accused Products
Abstract
An inhalable formulation containing SAE-CD and corticosteroid is provided. The formulation is adapted for administration to a subject by nebulization with any known nebulizer. The formulation can be included in a kit. The formulation is administered as an aqueous solution, however, it can be stored as a dry powder, ready-to-use solution, or concentrated composition. The formulation is employed in an improved nebulization system for administering corticosteroid by inhalation. SAE-CD present in the formulation significantly enhances the chemical stability of budesonide. A method of administering the formulation by inhalation is provided. The formulation can also be administered by conventional nasal delivery apparatus.
150 Citations
21 Claims
-
1. An aqueous liquid solution formulation comprising a therapeutically effective amount of corticosteroid dissolved therein, a sulfoalkyl ether cyclodextrin (SAE-CD), and an aqueous liquid carrier, wherein
i. the corticosteroid is budesonide; ii. the sulfoalkyl ether cyclodextrin has the structure; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
-
12. A solution based aerosol comprising an aqueous liquid carrier, a sulfoalkyl ether cyclodextrin (SAE-CD), and a dose of corticosteroid dissolved therein, wherein
i. the SAE-CD has the structure:
Specification