Method and device to monitor patients with kidney disease
First Claim
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1. A method for determining hyperkalemia, hypokalemia or arrhythmia and modifying a dialysis treatment, comprising:
- observing cardiac cycles of a subject by means of a medical device having one or more processor;
calculating at least one risk score using the one or more processor based upon a plurality of features of the cardiac cycle, the cycle associated with a time index and a risk score, wherein the risk score is calculated using a forward computational procedure;
sending an alert when at least one risk score exceeds a threshold for a defined time period, for a number of time indices, or for a certain fraction or number of time indices within a defined time period;
wherein one or more of a first risk score and a second risk score is calculated by one of the following;
the first risk score calculated by comparing one or more features selected from P-IR interval, QRS width, Q-T interval, QT-dispersion, P-wave amplitude, P-wave peak, S-T segment depression, T-wave inversion, U-wave amplitude, T-wave peak amplitude, and heart rate variability to corresponding value criteria, andthe second risk score calculated by comparing one or more features selected from QRS width, Q-T interval, P-wave amplitude, P-wave peak and T-wave amplitude to corresponding value criteria;
wherein at least one of the first risk score and the second risk score is calculated based upon assigning values to one or more selected from feature scores P1, P2, P3, P4, P5, P6, P7, P8, P9, and P10, wherein the set values are assigned as follows;
P1 based upon a comparison with the feature P-R interval in time units,P2 based upon a comparison with the feature QRS width in time units,P3 based upon a comparison with the feature Q-T interval in time units,P4 based upon a comparison with the feature P-wave amplitude in potential units per time unit,P5 based upon a comparison with the feature P-wave peak in potential unitsP6 based upon a comparison with the feature of depression of the S-T segment,P7 based upon a comparison with the feature of inversion of the T-wave,P8 based upon a comparison with the feature of U-wave amplitude in potential units,P9 based upon a comparison with the feature of T-wave amplitude in potential units, andP10 based upon a comparison with the feature of heart rate variation in time units; and
making a modification to the dialysis treatment received by the subject based upon a result of the forward computational procedure using the one or more processor.
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Abstract
A medical monitoring device for monitoring electrical signals from the body of a subject is described. The medical monitoring device monitors electrical signals originating from a cardiac cycle of the subject and associates each cardiac cycle with a time index. The medical monitoring device applies a forward computational procedure to generate a risk score indicative of hyperkalemia, hypokalemia or arrhythmia of the subject. The medical monitoring device can adjust the forward computational procedure based upon clinical data obtained from the subject.
216 Citations
20 Claims
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1. A method for determining hyperkalemia, hypokalemia or arrhythmia and modifying a dialysis treatment, comprising:
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observing cardiac cycles of a subject by means of a medical device having one or more processor; calculating at least one risk score using the one or more processor based upon a plurality of features of the cardiac cycle, the cycle associated with a time index and a risk score, wherein the risk score is calculated using a forward computational procedure; sending an alert when at least one risk score exceeds a threshold for a defined time period, for a number of time indices, or for a certain fraction or number of time indices within a defined time period; wherein one or more of a first risk score and a second risk score is calculated by one of the following; the first risk score calculated by comparing one or more features selected from P-IR interval, QRS width, Q-T interval, QT-dispersion, P-wave amplitude, P-wave peak, S-T segment depression, T-wave inversion, U-wave amplitude, T-wave peak amplitude, and heart rate variability to corresponding value criteria, and the second risk score calculated by comparing one or more features selected from QRS width, Q-T interval, P-wave amplitude, P-wave peak and T-wave amplitude to corresponding value criteria; wherein at least one of the first risk score and the second risk score is calculated based upon assigning values to one or more selected from feature scores P1, P2, P3, P4, P5, P6, P7, P8, P9, and P10, wherein the set values are assigned as follows; P1 based upon a comparison with the feature P-R interval in time units, P2 based upon a comparison with the feature QRS width in time units, P3 based upon a comparison with the feature Q-T interval in time units, P4 based upon a comparison with the feature P-wave amplitude in potential units per time unit, P5 based upon a comparison with the feature P-wave peak in potential units P6 based upon a comparison with the feature of depression of the S-T segment, P7 based upon a comparison with the feature of inversion of the T-wave, P8 based upon a comparison with the feature of U-wave amplitude in potential units, P9 based upon a comparison with the feature of T-wave amplitude in potential units, and P10 based upon a comparison with the feature of heart rate variation in time units; and making a modification to the dialysis treatment received by the subject based upon a result of the forward computational procedure using the one or more processor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A device for medical use, comprising:
at least one sensor detecting following parameters; blood pressure, heart rate, blood pH, and concentration of an electrolyte; a processor programmed to calculate at least one risk score by forward computation procedure based on the parameters, wherein the processor instructs a dialysis device to adjust dialysis treatment based on the at least one risk score; an alert to provide notice to a patient, a healthcare provider, or a medical professional if the at least one risk score exceeds a predetermined threshold. - View Dependent Claims (20)
Specification