System and method for determining ventilator leakage during stable periods within a breath

• US 10,207,069 B2
• Filed: 03/30/2009
• Issued: 02/19/2019
• Est. Priority Date: 03/31/2008
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Covidien LP (Medtronic Plc)
• Inventors: Jafari, Mehdi M., Jimenez, Rhomere S., Aviano, Jeffrey K., Upham, Gail F.
• Primary Examiner(s): Anderson, Gregory
• Assistant Examiner(s): Heffner, Ned T
• Application Number:
  US13/059,711
• Publication Number:
  US 20110259330A1
• Time in Patent Office: 3,613 Days
• CPC Class Codes: A61M 16/0063 Compressors
• CPC Class Codes: A61M 16/024 including calculation means, e.g. using a processor
• CPC Class Codes: A61M 2016/0021 with a proportional output signal, e.g. from a thermistor
• CPC Class Codes: A61M 2016/0027 pressure meter
• CPC Class Codes: A61M 2016/0033 electrical
• CPC Class Codes: A61M 2205/15 Detection of leaks
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/505 Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
• CPC Class Codes: A61M 2230/46 Resistance or compliance of the lungs

Abstract

Systems and methods for compensating for leaks in a ventilation system based on data obtained during periods within a breath in which the patient is neither inhaling nor exhaling. The methods and systems described herein more accurately and quickly identify changes in leakage. This information is then to estimate leakage later in the same breath or in subsequent breaths to calculate a more accurate estimate of instantaneous leakage based on current conditions. The estimated leakage is then used to compensate for the leak flow rates, reduce the patient'"'"'s work of breathing and increase the patient'"'"'s comfort (patient-ventilator breath phase transition synchrony).

Claims

1. A method for identifying leakage in a respiratory gas supply system, the respiratory gas supply system having a controller adapted for delivering a flow of respiratory gases to a breathing patient, the method comprising:

monitoring data indicative of at least one of pressure and flow in the respiratory gas supply system;

identifying, by the controller, that the data meet at least one stability criterion indicating that pressure and flow conditions have been stable for a period of time within a breath of a patient;

in response to the identifying that the data meet the at least one stability criterion, calculating leakage information based at least in part on the data identified during the period of time within the breath;

determining, by the controller, a leakage rate after the period of time based at least in part on the leakage information; and

adjusting at least one of a pressure and a flow delivered to the patient based on the determined leakage rate.

2. The method of claim 1 further comprising:

displaying the leakage rate to a user on a display.

3. The method of claim 1 wherein determining a leakage rate further comprises:

determining an instantaneous leakage rate after the period of time using only the leakage information and a pressure measurement taken after the period of time.

4. The method of claim 1 wherein determining a leakage rate further comprises:

determining an instantaneous leakage rate after the period of time using the leakage information and at least one current pressure measurement in the respiratory gas supply system.

5. The method of claim 1 further comprising:

monitoring data indicative of pressure at two different locations in a patient circuit.

6. The method of claim 1 further comprising:

monitoring data indicative of flow at two different locations in the patient circuit.

7. The method of claim 1 further comprising:

monitoring data indicative of at least one of pressure and flow at different locations in the patient circuit.

8. The method of claim 1 wherein calculating leakage information comprises:

calculating at least one constant based on data taken during the period of time, wherein the constant relates pressure to leakage rate in the respiratory gas supply system.

9. The method of claim 1 wherein calculating leakage information comprises:

calculating a first orifice constant representing the relationship between leakage flow through a hypothetical orifice and pressure in the respiratory gas supply system based on data taken during the period of time.

10. The method of claim 1 wherein identifying further comprises:

periodically analyzing, while providing therapy to a patient, a window of the data, wherein the window comprises recently monitored data, and wherein the periodic analyzing is performed to determine whether the window of the data meets the at least one stability criterion.

11. The method of claim 1 wherein identifying comprises:

calculating a first value indicative of a rate of change of pressure during at least a portion of the period of time;

comparing the first value to a first stability criterion; and

based at least in part on a result of the comparing of the first value to the first stability criterion, classifying the period of time as stable.

12. The method of claim 11 wherein identifying comprises:

calculating a second value indicative of a rate of change of flow during at least a portion of the period of time;

comparing the second value to a second stability criterion; and

based at least in part on a result of the comparing the second value, classifying the period of time as stable.

13. A respiratory gas supply system comprising:

a pressure generating system configured to control flow of breathing gas through a patient circuit and a patient interface to a patient; and

a computer controller communicatively coupled to the pressure generating system for adjusting the flow of breathing gas delivered to the patient, the computer controller configured to;

identify a stable period within at least one of an inhalation phase and an exhalation phase of a breath;

calculate leakage information using data obtained during the stable period identified by the stable period identification module;

calculate, during unstable periods within the breath or a later breath, an instantaneous leakage rate based on the leakage information; and

adjust at least one of a pressure and a flow delivered to the patient based on the determined leakage rate.

14. The respiratory gas supply system of claim 13, wherein identifying the stable period comprises comparing a window of recent pressure and flow data to a first set of one or more stability criteria during the inhalation phase.

15. The respiratory gas supply system of claim 14 wherein the first set of one or more stability criteria includes at least one criterion selection from a first criterion identifying a minimum pressure, a second criterion identifying a maximum pressure variation within the window, a third criterion identifying a maximum flow variation within the window and a fourth criterion based on a patient circuit type.

16. The respiratory gas supply system of claim 13 wherein identifying the stable period comprises comparing the window of recent pressure and flow data to a second set of one or more stability criteria during the exhalation phase.

17. The respiratory gas supply system of claim 16 wherein the second set of one or more stability criteria includes at least one criterion selected from a fifth criterion identifying a pressure threshold, a sixth criterion identifying a minimum time since the patient began to exhale, a seventh criterion identifying a minimum flow, an eighth criterion identifying a maximum pressure variation within the window and a ninth criterion identifying a maximum flow variation within the window.

18. A method for determining leakage from a respiratory gas supply system, the respiratory gas supply system having a controller adapted for providing respiratory gases to a breathing patient, comprising:

identifying, by the controller, at least one stable period within a breath of a patient;

calculating leakage information from pressure and flow data obtained during the at least one stable period;

subsequent to the at least one stable period, estimating, by the controller, a leakage from the respiratory gas supply system based on the leakage information and current data; and

adjusting at least one of a pressure and a flow delivered to the patient based on the determined leakage.

19. The method of claim 18 wherein calculating leakage information further comprises:

calculating a net leakage from the respiratory gas supply system during the at least one stable period based on measurements of respiratory gas flow to the patient and respiratory gas flow exiting the respiratory gas supply system.

20. The method of claim 18 wherein calculating leakage information further comprises:

calculating a representative pressure in the respiratory gas supply system during the at least one stable period based on measurements of pressure.

21. The method of claim 18 wherein calculating leakage information further comprises:

determining leakage information based on the net leakage from the respiratory gas supply system and the representative pressure.

22. The method of claim 20 wherein calculating a representative pressure comprises:

calculating a square root of an average pressure in the respiratory gas supply system during the at least one stable period.