Methods for measuring blood pressure

• US 10,213,116 B2
• Filed: 02/09/2016
• Issued: 02/26/2019
• Est. Priority Date: 11/18/2008
• Status: Active Grant

• Current Assignee: SunTech Medical, Inc. (Halma PLC)
• Original Assignee: SunTech Medical, Inc. (Halma PLC)
• Inventors: Chowienczyk, Philip Jan, Brett, Sally Emma, Guilcher, Antoine Yves Marie
• Primary Examiner(s): Jang, Christian
• Assistant Examiner(s): Alter, Mitchell E
• Application Number:
  US15/019,541
• Publication Number:
  US 20160150983A1
• Time in Patent Office: 1,113 Days
• CPC Class Codes: A61B 5/02108 from analysis of pulse wave characteristics
• CPC Class Codes: A61B 5/02116 of pulse wave amplitude A61B5/02225 takes precedence
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/02225 using the oscillometric method
• CPC Class Codes: A61B 5/7271 Specific aspects of physiological measurement analysis A61B5/316, A61B5/349 and A61B5/374 take precedence

Abstract

The application relates to an apparatus and a method for estimating a central systolic blood pressure (cSBP) of a subject, in which a peripheral blood pressure waveform of the subject'"'"'s pulse and at least two peripheral blood pressure measurements within the cardiac cycle of the subject are determined and the peripheral blood pressure waveform is manipulated with a transfer function to provide an estimate of the central blood pressure waveform of the subject'"'"'s pulse. The at least two peripheral blood pressure measurements within the cardiac cycle of the subject and the peripheral blood pressure waveform of the subject'"'"'s pulse are determined at substantially the same point on a peripheral artery of the subject. The estimate of the central blood pressure waveform of the subject'"'"'s pulse provides an estimate of the central systolic blood pressure of the subject.

Claims

1. A method of estimating a central systolic blood pressure (cSBP) of a human subject comprising:

obtaining a peripheral blood pressure waveform of a pulse of a human subject and at least two peripheral blood pressure measurements over at least one cardiac cycle of the human subject from a blood pressure cuff placed about an arm of the human subject about a brachial artery when pressure in the blood pressure cuff is inflated to a sub-systolic pressure;

applying a transfer function to the obtained peripheral blood pressure waveform to provide an estimate of a central blood pressure waveform of the subject;

calibrating the obtained peripheral blood pressure waveform using the at least two peripheral blood pressure measurements, wherein the at least two peripheral blood pressure measurements comprise at least two of peripheral systolic blood pressure (pSBP), peripheral diastolic blood pressure (pDBP) and peripheral mean arterial pressure (pMAP); and

electronically estimating the cSBP of the human subject using the calibrated peripheral blood pressure waveform and the estimate of the central blood pressure waveform.

2. The method of claim 1, wherein the obtaining, applying, calibrating and estimating are carried out using at least one processor in communication with the blood pressure cuff.

3. The method of claim 1, which the obtaining is carried out when inflation pressure in the blood pressure cuff is adjusted to a pDBP of the human subject plus between 5% and 95% of a pulse pressure of the human subject.

4. The method of claim 1, wherein the at least two peripheral blood pressure measurements are only pSBP and pDBP.

5. The method of claim 1, wherein the at least two peripheral blood pressure measurements are only pDBP and pMAP.

6. The method of claim 1, wherein the obtaining the peripheral blood pressure waveform of the subject'"'"'s pulse comprises recording a least 10 peripheral blood pressure waveforms corresponding to at least 10 cardiac cycles and averaging the waveforms to obtain a single average peripheral blood pressure waveform, and wherein the calibration and the applying actions are carried out using the average peripheral blood pressure waveform.

7. The method of claim 1, further comprising electronically calculating a peripheral augmentation index (AI) using the relationship;

AI=(cSBP−

DBP)/(pSBP−

DBP).

8. The method of claim 1, wherein the transfer function has a cutoff frequency of 3.12 Hz and a gain of 0 db.

9. The method of claim 1, wherein the transfer function comprises a Butterworth 1^st order filter.

17. The method of claim 1, further comprising electronically displaying the estimated cSBP of the human subject.

18. The method of claim 1, further comprising electronically providing the estimated cSBP of the human subject via an oscillometric BP monitor.

10. A method of estimating a central systolic blood pressure (cSBP) comprising:

obtaining a peripheral blood pressure waveform of a pulse of a human subject and at least two peripheral blood pressure measurements over at least one cardiac cycle of the human subject from a blood pressure cuff placed about a brachial artery of an arm of the human subject when pressure in the blood pressure cuff is inflated to a sub-systolic pressure;

calibrating the obtained peripheral blood pressure waveform using the at least two peripheral blood pressure measurements, wherein the at least two peripheral blood pressure measurements comprise at least two of peripheral systolic blood pressure (pSBP), peripheral diastolic blood pressure (pDBP) and peripheral mean arterial pressure (pMAP);

applying a transfer function to the obtained peripheral blood pressure waveform to provide an estimate of a central blood pressure waveform; and

electronically estimating the cSBP of the human subject using the peripheral blood pressure waveform and with the calibration and the estimate of the central blood pressure waveform.

11. The method of claim 10, wherein the obtaining, applying, calibrating and estimating are carried out using at least one processor in communication with the blood pressure cuff.

12. The method of claim 10, which the obtaining is carried out when pressure in the blood pressure cuff is adjusted to a pDBP of the human subject plus between 5% and 95% of a pulse pressure of the human subject.

13. The method of claim 10, wherein the at least two peripheral blood pressure measurements are only pSBP and pDBP or only pDBP and pMAP.

14. The method of claim 11, wherein the obtaining the peripheral blood pressure waveform of the subject'"'"'s pulse comprises recording a least 10 peripheral blood pressure waveforms corresponding to at least 10 cardiac cycles and averaging the waveforms to obtain a single average peripheral blood pressure waveform, and wherein the calibration and the applying actions are carried out using the average peripheral blood pressure waveform.

15. The method of claim 10, further comprising electronically calculating a peripheral augmentation index (AI) using the relationship;

AI=(cSBP−

DBP)/(pSBP−

DBP).

16. The method of claim 10, wherein the transfer function has a cutoff frequency of 3.12 Hz and a gain of 0 db and/or wherein the transfer function comprises a Butterworth 1^St order filter.