Gas powered system for performing remote ischemic conditioning

• US 10,213,206 B2
• Filed: 03/12/2014
• Issued: 02/26/2019
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: CellAegis Devices, Inc.
• Original Assignee: CellAegis Devices, Inc.
• Inventors: Ganske, Rocky Eugene, Cracauer, Raymond, Gil, Lahav
• Primary Examiner(s): Rodjom, Katherine
• Application Number:
  US14/774,009
• Publication Number:
  US 20160022269A1
• Time in Patent Office: 1,812 Days
• CPC Class Codes: A61B 17/12 for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord specially adapted for vas deferens or fallopian tubes A61F6/20; materials for ligaturing blood vessels A61L17/00
• CPC Class Codes: A61B 17/135 inflatable for measuring blood pressure A61B5/022; inflatable pressure pads A61F5/34
• CPC Class Codes: A61B 17/1355 Automated control means therefor
• CPC Class Codes: A61B 2017/00221 with wireless transmission of data, e.g. by infrared radiation or radiowaves
• CPC Class Codes: A61B 2017/00548 Gas cartridges therefor
• CPC Class Codes: A61B 2017/00876 magnetic
• CPC Class Codes: A61B 2090/032 pressure limiting, e.g. hydrostatic
• CPC Class Codes: A61B 2090/064 for measuring force, pressure or mechanical tension
• CPC Class Codes: A61H 1/008 Apparatus for applying pressure or blows almost perpendicular to the body or limb axis, e.g. chiropractic devices for repositioning vertebrae, correcting deformation
• CPC Class Codes: A61H 2201/5097 wireless
• CPC Class Codes: A61M 39/22 Valves or arrangement of valves A61M39/02, A61M39/0247, A61M39/16 take precedence; regulating valves in infusion systems A61M5/16881; in devices worn by the patient for the reception of urine, faeces, catamenial or other discharge, or in colostomy devices A61F5/4405
• CPC Class Codes: A61M 39/24 Check- or non-return valves

Abstract

A device for performing a remote ischemic conditioning treatment. The device includes an inflatable cuff and a cartridge which is a source of gas for inflating the cuff. A first valve controls the flow of gas from the cartridge to the cuff so as to maintain a predetermined pressure in the cuff during an ischemic period. A second valve allows gas to escape from the cuff during a reperfusion period of the remote ischemic conditioning treatment. A controller which may be battery-powered is used to control the opening and closing of the valves. The cartridge may contain a gas, or materials which, under certain conditions, react to produce a gas. The chemical reaction may be initiated by an electrical pulse or signal from the controller.

Claims

1. A device for remote ischemic conditioning comprising:

an inflatable cuff configured to encircle a limb of a user;

multiple cartridges fluidly coupled to the cuff at one time for providing a source of gas to the cuff;

a manifold providing fluid communication between all of the cartridges and the cuff;

a plurality of first valves disposed between the cartridges and the cuff to control a flow of gas from the cartridges to the cuff, each first valve being associated only with a respective one of the cartridges, each first valve being selectively opened or closed to control a flow of gas only from its respective cartridge;

a second valve in fluid communication with the cuff which, when opened, allows gas in the cuff to escape from the cuff; and

a controller configured to selectively open the first valves to permit a flow of gas from each respective cartridge in a desired sequence to the cuff to implement a remote ischemic conditioning treatment having more than one cycle, each cycle having at least one period of ischemia and one period of reperfusion;

wherein each cartridge is associated with a different cycle in the remote ischemic conditioning treatment to produce ischemia during an ischemic period.

2. The device of claim 1, further comprising a third valve disposed in fluid communication with the cuff and configured to open in response to an over-pressure event.

3. The device of claim 2, further comprising a pressure monitor which senses the pressure in the cuff and/or in the manifold, and opens the third valve when the pressure in the manifold or in the cuff exceeds a predetermined value.

4. The device of claim 1, further comprising a pressure monitor and wherein the controller and pressure monitor maintain a cuff pressure between preselected pressure limits during an ischemic period of the remote ischemic conditioning treatment.

5. The device of claim 1, wherein the cartridges contain a gas in a gaseous state.

6. The device of claim 1, wherein the cartridges contain a gas in a liquified state that transforms into a gaseous state upon release from the cartridges.

7. The device of claim 1, wherein the cartridges contain chemicals which, when activated by the controller, react to produce gas.

8. The device of claim 7, wherein a chemical reaction is initiated by sending a signal from the controller to the cartridges.

9. The device of claim 1, wherein all of the cartridges are disposed at one time in a housing on the cuff.

10. The device of claim 1, wherein all of the cartridges are is disposed at one time in the cuff.

11. The device of claim 1, wherein there is no battery that provides electrical power to the controller.

12. The device of claim 11, further comprising a piezoelectric generator for providing electrical power to the controller.

13. The device of claim 12, wherein the piezoelectric generator is powered by diverting gas from one of the cartridges to the generator.

14. The device of claim 1, further comprising a whistle that generates a sound resulting from gas being diverted from one of the cartridges to the whistle.

15. The device of claim 11, wherein the controller and at least one of the first and second valves includes pneumatic logic powered by gas diverted from one of the cartridges.

16. A device for performing a remote ischemic conditioning protocol, the device comprising;

an inflatable cuff configured to encircle a limb of a user;

a housing attached to the cuff;

multiple cartridges fluidly coupled to the cuff at one time and containing a gas or a gas-producing material;

a manifold disposed between the cartridges and the cuff to provide fluid communication between the cartridges and the cuff;

a plurality of first valves disposed between the cartridges and the manifold to control a flow of gas from the cartridges to the cuff, each first valve being associated only with a respective one of the cartridges, each first valve being selectively opened or closed to control a flow of gas only from its respective cartridge;

a second valve in fluid communication with the cuff and the manifold for allowing gas within the manifold and/or the cuff to escape therefrom when in an open condition;

a controller configured to selectively control the opening and closing of the first valves to permit a flow of gas from each respective cartridge in a desired sequence to the cuff to permit the cuff to be inflated during an ischemic period as part of a remote ischemic conditioning treatment; and

a battery to provide power to the controller.

17. The device of claim 16, wherein the housing includes a switch to initiate a remote ischemic conditioning treatment and a light to indicate the status of the treatment.

18. The device of claim 16, wherein the cartridges contain a gas in a liquid form.

19. The device of claim 16, wherein the cartridges contain chemicals which react to produce gas.

20. The device of claim 19, wherein a chemical reaction is initiated by an electrical pulse sent from the controller.

21. The device of claim 16, wherein all of the cartridges are disposed at one time within the housing.

22. The device of claim 16, wherein all of the cartridges are disposed at one time within the cuff.