Inducing desirable temperature effects on body tissue
First Claim
1. A system for remodeling tissue disposed about a blood vessel, the system comprising:
- an endovascular catheter having an energy delivery portion adapted to be coupled with a target tissue, wherein the catheter includes a balloon, wherein the energy delivery portion comprises a plurality of electrodes disposed about the balloon of the catheter so as to define a plurality of remodeling zones in the target tissue when the balloon is in contact with a blood vessel wall disposed adjacent to the target tissue; and
an energy source coupleable with the catheter, the energy source being configured to deliver a controlled quantity of energy to each of the plurality of electrodes in response to an input such that the controlled quantity of energy heats at least some of the plurality of remodeling zones of the target tissue so as to remodel the target tissue and inhibit thermal damage of collateral healthy tissues;
wherein the plurality of remodeling zones includes a first remodeling zone and a second remodeling zone disposed adjacent to the first remodeling zone and wherein the plurality of electrodes comprise a plurality of bipolar electrode pairs spaced around an axis of the balloon so that the plurality of remodeling zones defined by the bipolar electrode pairs are laterally separated from each other so as to form gaps between the first remodeling zone and the second remodeling zone;
wherein the energy source includes a processor, wherein the processor is designed to determine a frequency or range of frequencies at which a first impedance of the target tissue is equal to or greater than a second impedance of the collateral healthy tissue; and
wherein the processor is configured to deliver the controlled quantity of energy delivered to the plurality of electrodes at the frequency or range of frequencies.
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Accused Products
Abstract
Methods and systems are disclosed for treating diseased tissue by gentle heating. The method induces vasodilation on tissue disposed about an lumen having both healthy tissue and diseased tissue. The method includes coupling a probe surface to the luminal tissue at a target location and transmitting desired quantities of tissue remodeling energy from the coupled probe into each of a plurality of discrete remodeling zones in the luminal tissue so that the tissue remodeling energy heats the plurality of remodeling zones, the remodeling energy being configured to avoid muscular contraction and inhibit both acute and long-term occlusion of the lumen.
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Citations
13 Claims
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1. A system for remodeling tissue disposed about a blood vessel, the system comprising:
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an endovascular catheter having an energy delivery portion adapted to be coupled with a target tissue, wherein the catheter includes a balloon, wherein the energy delivery portion comprises a plurality of electrodes disposed about the balloon of the catheter so as to define a plurality of remodeling zones in the target tissue when the balloon is in contact with a blood vessel wall disposed adjacent to the target tissue; and an energy source coupleable with the catheter, the energy source being configured to deliver a controlled quantity of energy to each of the plurality of electrodes in response to an input such that the controlled quantity of energy heats at least some of the plurality of remodeling zones of the target tissue so as to remodel the target tissue and inhibit thermal damage of collateral healthy tissues; wherein the plurality of remodeling zones includes a first remodeling zone and a second remodeling zone disposed adjacent to the first remodeling zone and wherein the plurality of electrodes comprise a plurality of bipolar electrode pairs spaced around an axis of the balloon so that the plurality of remodeling zones defined by the bipolar electrode pairs are laterally separated from each other so as to form gaps between the first remodeling zone and the second remodeling zone; wherein the energy source includes a processor, wherein the processor is designed to determine a frequency or range of frequencies at which a first impedance of the target tissue is equal to or greater than a second impedance of the collateral healthy tissue; and
wherein the processor is configured to deliver the controlled quantity of energy delivered to the plurality of electrodes at the frequency or range of frequencies. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A system for remodeling tissue disposed about a blood vessel, the system comprising:
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a catheter balloon having a plurality of electrode pairs disposed about the catheter balloon so that the balloon is adapted to couple with a wall of the blood vessel to define a plurality of laterally separated remodeling zones in a target tissue when the balloon is expanded within the blood vessel; an energy source coupled with the plurality of electrode pairs and configured to energize the plurality of electrode pairs with a desired tissue remodeling energy to heat each of the plurality of laterally separated remodeling zones so as to remodel the target tissue while avoiding thermal damage of the blood vessel; wherein the plurality of remodeling zones includes a first remodeling zone and a second remodeling zone disposed adjacent to the first remodeling zone and wherein the plurality of electrodes comprise a plurality of bipolar electrode pairs spaced around an axis of the balloon so that the plurality of remodeling zones defined by the bipolar electrode pairs are laterally separated from each other so as to form gaps between the first remodeling zone and the second remodeling zone; and wherein the energy source includes a processor, wherein the processor is designed to determine a frequency or range of frequencies at which a first impedance of the target tissue is equal to or greater than a second impedance of the collateral healthy tissue, wherein the processor is configured to deliver a quantity of energy delivered to the plurality of electrode pairs at or below the frequency or range of frequencies.
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Specification