×

Peptidomimetic macrocycles

  • US 10,213,477 B2
  • Filed: 08/05/2016
  • Issued: 02/26/2019
  • Est. Priority Date: 02/15/2012
  • Status: Active Grant
First Claim
Patent Images

1. A method for treating a cancer, comprising administering to a subject with the cancer a therapeutically effective amount of a pharmaceutical product comprising:

  • (a) a first therapeutic agent comprising an inhibitor of an interaction between p53 and MDM2 and/or an inhibitor of an interaction between p53 and MDMX, and(b) a second therapeutic agent comprising a chemotherapeutic agent;

    wherein the first therapeutic agent is a peptidomimetic macrocycle comprising an amino acid sequence with at least about 90% sequence identity to an amino acid sequence selected from the group consisting of SEQ IP NOs;

    10-457, or pharmaceutically acceptable salt thereof; and

    wherein the peptidomimetic macrocycle has a Formula;

View all claims
  • 3 Assignments
Timeline View
Assignment View
    ×
    ×