Medicament delivery device and method of controlling the device

• US 10,213,557 B2
• Filed: 01/20/2017
• Issued: 02/26/2019
• Est. Priority Date: 05/25/2011
• Status: Active Grant

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: Eggert, Ilona, Langley, Christopher Nigel, Day, Shane Alistair
• Primary Examiner(s): Vu, Quynh-Nhu H.
• Application Number:
  US15/411,346
• Publication Number:
  US 20170143908A1
• Time in Patent Office: 767 Days
• CPC Class Codes: A61M 2005/1787 Syringes for sequential delivery of fluids, e.g. first medicament and then flushing liquid
• CPC Class Codes: A61M 2005/2407 from the rear
• CPC Class Codes: A61M 2005/2474 with movable piercing means, e.g. ampoule remains fixed or steady
• CPC Class Codes: A61M 2005/2496 via pivot
• CPC Class Codes: A61M 2005/3118 via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
• CPC Class Codes: A61M 2005/3128 Incorporating one-way valves, e.g. pressure-relief or non-return valves
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/14566 with a replaceable reservoir for receiving a piston rod of the pump
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/3146 Priming, e.g. purging, reducing backlash or clearance
• CPC Class Codes: A61M 5/31546 Electrically operated dose setting, e.g. input via touch screen or plus/minus buttons
• CPC Class Codes: A61M 5/345 Adaptors positioned between needle hub and syringe nozzle
• CPC Class Codes: G16H 40/63 for local operation

Abstract

A medicament delivery device is shown for the administration of one or more drug agents. The device has a priming mode and a drug delivery mode for administering delivery of the one or more drug agents. The device comprises a controller configured to set the device in a priming mode when one or more predetermined states of the device are identified and to disable the drug delivery mode during said predetermined state(s). When states of the device are different from said predetermined states, the controller can set the device in the drug delivery mode. A priming mode may still be enabled through a user interface.

Claims

1. A method of controlling a medicament delivery device for the administration of one or more drug agents, wherein the device has a plurality of states including a predetermined state, the method comprising:

determining that the device is in the predetermined state;

responsive to determining that the device is in the predetermined state, setting the device in a priming mode and disabling a drug delivery mode during said predetermined state, wherein the priming mode is for priming the device and the drug delivery mode is for administering delivery of a dose of the one or more drug agents;

determining that the device is in a state different than the predetermined state;

responsive to determining that the device is in a state different than the predetermined state, setting the device in the drug delivery mode while maintaining enablement of the priming mode;

facilitating selection, via a user interface, between the priming mode and the drug delivery mode when the device is in said state different than the predetermined state, wherein the user interface is configured to provide a first selectable option for priming the device and a second selectable option for delivering a dose; and

responsive to determining that the device is in the predetermined state, providing on the user interface the first selectable option and not the second selectable option to thereby set the device in a mandatory priming mode.

2. The method according to claim 1,

wherein setting the device in the drug delivery mode while maintaining enablement of the priming mode comprises providing, by the user interface, both the first selectable option and the second selectable option to facilitate selection between the priming mode and the drug delivery mode.

3. The method according to claim 2, further comprising:

actuating, on the user interface, the first selectable option for the priming mode; and

responsive to actuating the first selectable option, ejecting a preset quantity of medicament from the device to prime the device.

4. The method according to claim 3, wherein the preset quantity of medicament is based on the determined predetermined state.

5. The method according to claim 2, further comprising:

selecting, using the user interface, a number of discrete units;

actuating, on the user interface, the first selectable option for the priming mode; and

responsive to actuating the first selectable option, ejecting from the device a quantity of medicament corresponding to the selected number of discrete units.

6. The method according to claim 2, further comprising:

responsive to setting the device in the drug delivery mode, actuating the second selectable option on the user interface; and

responsive to actuating the second selectable option, enabling a dose setting device for the drug delivery mode.

7. The method according to claim 1, wherein determining that the device is in said predetermined state comprises determining when a dispense interface is placed from a detached to an attached relationship with the device.

8. The method according to claim 1, wherein determining that the device is in said predetermined state comprises determining when a dispense interface is attached to the device and no dose of medicament has been dispensed from the device since the attachment of the dispense interface to the device.

9. The method according to claim 1, further comprising prompting a user, via an output device, to prime the device responsive to determining the device is in said predetermined state.

10. The method according to claim 1, wherein the medicament delivery device comprises a first retainer and a second retainer each for holding a medicament cartridge containing a drug agent.

11. The method according to claim 10, further comprising, when the device is set in the drug delivery mode while maintaining enablement of the priming mode, priming the device from a designated one of the medicament cartridges of the first retainer and the second retainer provided the time that has elapsed since a previous dose or since a previous priming of the device is less than a predetermined value of time.

12. The method according to claim 10, further comprising when the device is set in the drug delivery mode while maintaining enablement of the priming mode, priming the device from both of the medicament cartridges of the first retainer and the second retainer if the time that has elapsed since a previous dose or since a previous priming of the device is greater than a predetermined value of time.

13. A method of controlling a medicament delivery device for the administration of one or more drug agents, wherein the device has (i) a priming mode for discharging air or a residual medicament from the device and (ii) a drug delivery mode for administering delivery of a dose of the medicament, wherein the device has a plurality of states including one or more first states and one or more second states, wherein the device has a user interface having a priming button for activating the priming mode and a dose-delivery button for activating the drug delivery mode, the method comprising:

determining whether the device is in at least one of the one or more first states;

responsive to determining that the device is in at least one of the one or more first states, enabling the priming mode via the priming button of the user interface and disabling the drug delivery mode via the drug-delivery button of the user interface during the at least one of the one or more first states, wherein enabling the priming mode and disabling the drug-delivery mode sets the device in a mandatory priming mode, and wherein during the mandatory priming mode the dose of the medicament cannot be delivered;

determining whether the device is in at least one of the one or more second states; and

responsive to determining that the device is in at least one of the one or more second states, enabling the priming mode via the priming button of the user interface and enabling the drug delivery mode via the drug-delivery button of the user interface during the at least one of the one or more second states.

14. The method according to claim 13, further comprising:

actuating, on the user interface, the priming button; and

responsive to actuating the priming button, ejecting a preset quantity of medicament from the device to prime the device,

wherein the preset quantity is based on the state of the device when the priming button is actuated.

15. The method according to claim 13, further comprising:

selecting, using the user interface, a number of discrete units;

actuating, on the user interface, the priming button; and

responsive to actuating the priming button, ejecting from the device a quantity of medicament corresponding to the selected number of discrete units.

16. The method according to claim 13, further comprising:

responsive to setting the device in the drug delivery mode, actuating the drug-delivery button; and

responsive to actuating the drug-delivery button, enabling a dose setting device for the drug delivery mode.

17. The method according to claim 13, wherein determining that the device is in said at least one of the one or more first states comprises determining when a dispense interface is placed from a detached to an attached relationship with the device.

18. The method according to claim 13, wherein determining that the device is in said at least one of the one or more first states comprises determining when a dispense interface is attached to the device and no dose of medicament has been dispensed from the device since the attachment of the dispense interface to the device.