×

Coating process for microfluidic sample arrays

  • US 10,213,761 B2
  • Filed: 06/09/2014
  • Issued: 02/26/2019
  • Est. Priority Date: 08/04/2004
  • Status: Active Grant
First Claim
Patent Images

1. A method for differentially coating a substrate, the method comprising:

  • supplying a substrate comprising an external surface and a plurality of through-hole channels each comprising an interior surface in communication with the exterior surface;

    applying a first coating agent simultaneously to both the exterior surface and to at least one of the interior surfaces;

    selectively oxidizing the at least one interior surface with an oxidizing agent;

    after selectively oxidizing, selectively modifying the first coating agent applied to the at least one interior surface with a first modifying agent such that, after modifying, the at least one interior surface has a first specified physicochemical property that differs with respect to a specified physicochemical property of the external surface; and

    applying a second modifying agent to the at least one interior surface;

    wherein at least one of (1) the first coating agent comprises a vinyl terminated compound or (2) the first and second modifying agents each comprise a polyethylene glycol.

View all claims
  • 5 Assignments
Timeline View
Assignment View
    ×
    ×