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Lipid bilayer sensor system

  • US 10,215,768 B2
  • Filed: 06/04/2015
  • Issued: 02/26/2019
  • Est. Priority Date: 02/20/2007
  • Status: Active Grant
First Claim
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1. A sensor system for measuring an electrical signal across a lipid bilayer, the sensor system comprising a cell and a portable electrical reader unit which are connectable together;

  • wherein the cell defines two chambers separated by a septum, the septum comprising a membrane having an aperture capable of supporting a lipid bilayer and arranged between the chambers, wherein the chambers each have a volume in the range from 0.1 μ

    L to 250 μ

    L, and a depth of at most 3 mm between the septum and a respective closure sheet for each chamber,such that surface tension of a liquid in the chamber contains the liquid across an area of the chamber parallel to the septum, andsuch that an interface of the liquid with air in the chamber extends across the depth of the chamber;

    wherein the cell has electrodes formed in each chamber for receiving an electrical signal developed between the chambers,wherein the electrical reader unit has a reader circuit operative to measure an electrical signal developed between the chambers of the cell, andwherein the cell and the electrical reader unit are arranged to be connected together to provide electrical connection between the electrodes of the cell and the reader circuit of the electrical reader unit.

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