Impedance devices for obtaining conductance measurements within luminal organs

• US 10,219,720 B2
• Filed: 11/11/2014
• Issued: 03/05/2019
• Est. Priority Date: 02/21/2003
• Status: Active Grant

• Current Assignee: 3DT Holdings LLC
• Original Assignee: 3DT Holdings LLC
• Inventors: Kassab, Ghassan S.
• Primary Examiner(s): Cerioni, Daniel L
• Application Number:
  US14/538,413
• Publication Number:
  US 20150065835A1
• Time in Patent Office: 1,575 Days
• Field of Search: 600547
• CPC Class Codes: A61B 2017/00026 Conductivity or impedance, e.g. of tissue
• CPC Class Codes: A61B 2017/22051 with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation A61B2017/22048, A61B2017/3486 take precedence
• CPC Class Codes: A61B 2018/2238 with means for selectively laterally deflecting the tip of the fibre
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/1076 for measuring dimensions inside body cavities, e.g. using catheters A61B3/1005 takes precedence
• CPC Class Codes: A61B 5/6851 Guide wires
• CPC Class Codes: A61B 5/6853 with a balloon

Abstract

Impedance devices for obtaining conductance measurements within luminal organs. In at least one embodiment of an impedance device of the present disclosure, the device, comprises an elongated body and an detector positioned upon the elongated body, the detector comprising at least five electrodes and configured to obtain one or more conductance measurements generated using a first arrangement of four of the at least five electrodes and further configured to obtain one or more fluid velocity measurements using a second arrangement of four of the at least five electrodes when the elongated body is positioned within a fluid environment of a mammalian luminal organ, wherein the first arrangement is different from the second arrangement.

Claims

1. An impedance device, comprising:

an elongated body; and

a detector positioned upon the elongated body, the detector comprising at least four electrodes configured to obtain one or more conductance measurements within a luminal organ comprising a diameter, the at least four electrodes comprising at least a most distal electrode, an electrode immediately adjacent to the most distal electrode, a proximal electrode, and an electrode immediately adjacent to the proximal electrode;

wherein the most distal electrode is spaced at least 3 mm from the electrode immediately adjacent to the most distal electrode, wherein the electrode immediately adjacent to the most distal electrode is spaced at least 2 mm from the electrode immediately adjacent to the proximal electrode, and wherein the electrode immediately adjacent to the proximal electrode is spaced at least 6 mm from the proximal electrode, and wherein the distance between the most distal electrode and the proximal electrode is at least two times the diameter of the luminal organ;

wherein the most distal electrode and the most proximal electrode are not equidistant to the electrode immediately adjacent to the most distal electrode and the electrode immediately adjacent to the most proximal electrode, respectively; and

wherein a distance between the electrode immediately adjacent to the most distal electrode and the electrode immediately adjacent to the proximal electrode is smaller than a distance between the most distal electrode and the electrode immediately adjacent to the most distal electrode and also smaller than a distance between the proximal electrode and the electrode immediately adjacent to the proximal electrode.

2. The impedance device of claim 1, wherein the most distal electrode is spaced at least 5 mm from the electrode immediately adjacent to the most distal electrode, and wherein the electrode immediately adjacent to the proximal electrode is spaced at least 10 mm from the proximal electrode.

3. The impedance device of claim 1, wherein the elongated body is selected from the group consisting of a wire and a catheter.

4. The impedance device of claim 1, wherein the most distal electrode and the proximal electrode are spaced at or about 11 mm from each other.

5. The impedance device of claim 1, wherein the most distal electrode and the proximal electrode are spaced at or about 18 mm from each other.

6. The impedance device of claim 1, further comprising:

an inflatable balloon positioned along the longitudinal axis of the elongated body located proximal to the detector, wherein the inflatable balloon is in communication with a lumen defined within the elongated body.

7. The impedance device of claim 6, further comprising:

a tetrapolar detector positioned upon the elongated body within the balloon, the tetrapolar detector comprising two excitation electrodes and two detection electrodes operable to obtain one or more balloon cross-sectional areas.

8. An impedance device, comprising:

an elongated body selected from the group consisting of a wire and a catheter; and

a detector positioned upon the elongated body, the detector comprising at least four electrodes configured to obtain one or more conductance measurements within a luminal organ of at least 4 mm in diameter, the at least four electrodes comprising at least a most distal electrode, an electrode immediately adjacent to the most distal electrode, a proximal electrode, and an electrode immediately adjacent to the proximal electrode;

wherein the most distal electrode is spaced between 3 mm and 5 mm from the electrode immediately adjacent to the most distal electrode, wherein the electrode immediately adjacent to the most distal electrode is spaced about 2 mm from the electrode immediately adjacent to the proximal electrode, and wherein the electrode immediately adjacent to the proximal electrode is spaced at least 6 mm from the proximal electrode; and

wherein the distance between the most distal electrode and the proximal electrode is at least two times the diameter of the luminal organ.

9. The impedance device of claim 8, wherein the most distal electrode is spaced at least 5 mm from the electrode immediately adjacent to the most distal electrode, wherein the electrode immediately adjacent to the most distal electrode is spaced at least 2 mm from the electrode immediately adjacent to the proximal electrode and wherein the electrode immediately adjacent to the proximal electrode is spaced at least 10 mm from the proximal electrode.

10. The impedance device of claim 8, further comprising:

four additional electrodes positioned upon the elongated body, the four additional electrodes and the at least four electrodes comprising at least eight electrodes, wherein two electrodes of the at least eight electrodes are configured to excite an electric field within a luminal organ, and wherein six electrodes of the at least eight electrodes form three pairs of detection electrodes that are configured to sense the electric field at three locations along the elongated body.

11. The impedance device of claim 8, further comprising:

ten additional electrodes positioned upon the elongated body, the ten additional electrodes and the at least four electrodes comprising at least fourteen electrodes, wherein two electrodes of the at least fourteen electrodes are configured to excite an electric field within a luminal organ, and wherein twelve electrodes of the at least fourteen electrodes form six pairs of detection electrodes that are configured to sense the electric field at six locations along the elongated body.

12. An impedance device, comprising:

an elongated body; and

a detector positioned upon the elongated body, the detector comprising at least five electrodes, the at least five electrodes comprising;

a most distal electrode,

an electrode immediately adjacent to the most distal electrode,

a most proximal electrode,

an electrode immediately adjacent to the most proximal electrode, and

a central electrode positioned between the electrode immediately adjacent to the most distal electrode and the electrode immediately adjacent to the most proximal electrode,

wherein the electrode immediately adjacent to the most distal electrode is spaced at least 1 mm from the central electrode;

wherein the most distal electrode and the most proximal electrode are not equidistant to the electrode immediately adjacent to the most distal electrode and the electrode immediately adjacent to the most proximal electrode, respectively; and

wherein a distance between the electrode immediately adjacent to the most distal electrode and the electrode immediately adjacent to the proximal electrode is smaller than a distance between the most distal electrode and the electrode immediately adjacent to the most distal electrode and also smaller than a distance between the proximal electrode and the electrode immediately adjacent to the proximal electrode;

wherein the impedance device is configured to obtain one or more conductance measurements and one of more fluid velocity measurements when the elongated body is positioned within a fluid environment of a mammalian luminal organ, wherein the distance between the most distal electrode and the proximal electrode is at least two times the diameter of the luminal organ.

13. The impedance device of claim 12, wherein the elongated body is selected from the group consisting of a wire and a catheter.

14. The impedance device of claim 12, wherein a first arrangement of electrodes comprises the most distal electrode, the electrode immediately adjacent to the most distal electrode, the central electrode, and the electrode immediately adjacent to the most proximal electrode, wherein the most distal electrode and the electrode immediately adjacent to the most proximal electrode are capable of excitation to generate an electric field, and wherein the electrode immediately adjacent to the most distal electrode and the central electrode are configured to obtain the one or more conductance measurements within the electric field.

15. The impedance device of claim 14, wherein one or more cross-sectional areas can be calculated based in part upon the one or more conductance measurements and a known distance between the electrode immediately adjacent to the most distal electrode and the central electrode.

16. The impedance device of claim 12, wherein the second arrangement of electrodes comprises the most distal electrode, the electrode immediately adjacent to the most distal electrode, the central electrode, and the most proximal electrode, wherein the most distal electrode and the most proximal electrode are capable of excitation to generate an electric field, wherein the most distal electrode and the electrode immediately adjacent to the most distal electrode comprise a first fluid velocity detection electrode pair, and wherein the central electrode and the most proximal electrode comprise a second fluid velocity detection pair.

17. The impedance device of claim 12, wherein the most distal electrode is spaced 4 mm from the an electrode immediately adjacent to the most distal electrode, wherein the electrode immediately adjacent to the most distal electrode is spaced 1 mm from the central electrode, wherein the central electrode is spaced 4 mm from the electrode immediately adjacent to the most proximal electrode, and wherein the electrode immediately adjacent to the most proximal electrode is spaced 8 mm from the most proximal electrode.

18. The impedance device of claim 12, wherein the most distal electrode is spaced 3 mm from the an electrode immediately adjacent to the most distal electrode, wherein the electrode immediately adjacent to the most distal electrode is spaced 2 mm from the central electrode, and wherein the central electrode is spaced 6 mm from the electrode immediately adjacent to the most proximal electrode.

19. The impedance device of claim 12, wherein the most distal electrode is spaced 5 mm from the an electrode immediately adjacent to the most distal electrode, wherein the electrode immediately adjacent to the most distal electrode is spaced 2 mm from the central electrode, and wherein the central electrode is spaced 10 mm from the electrode immediately adjacent to the most proximal electrode.