Apparatus and methods for detecting optical signals from implanted sensors

• US 10,219,729 B2
• Filed: 06/06/2014
• Issued: 03/05/2019
• Est. Priority Date: 06/06/2013
• Status: Active Grant

• Current Assignee: Profusa, Inc.
• Original Assignee: Profusa, Inc.
• Inventors: Kintz, Gregory J., McMillan, William A., Wisniewski, Natalie A.
• Primary Examiner(s): Winakur, Eric
• Assistant Examiner(s): Fardanesh, Marjan
• Application Number:
  US14/297,787
• Publication Number:
  US 20140364707A1
• Time in Patent Office: 1,733 Days
• Field of Search: None
• CPC Class Codes: A61B 2562/0233 Special features of optical sensors or probes classified in A61B5/00
• CPC Class Codes: A61B 2562/043 in a linear array
• CPC Class Codes: A61B 5/0017 transmitting optical signals transmission by light H04B10/00
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence

Abstract

Some embodiments described herein relate to an apparatus including a light source configured to transmit an excitation optical signal to an implanted sensor and a detector configured to detect an analyte-dependent optical signal emitted from an implanted sensor. The apparatus can include a lens configured to focus at least a portion of the analyte-dependent optical signal onto the detector.

Claims

1. An apparatus, comprising:

a planar base;

a light source coupled to the planar base and configured to transmit an excitation optical signal through a first surface area of skin to an implanted sensor;

one or more detectors coupled to the planar base and configured to detect an analyte-dependent optical signal emitted from the implanted sensor through a second surface area of skin in response to the implanted sensor being illuminated by the excitation optical signal, the second surface area of the skin being at least four times the first surface area of the skin;

a first lens from an array of lenses, the first lens configured to focus at least a portion of the analyte-dependent optical signal onto at least one of the one or more detectors, the first lens defining a first lens axis; and

a second lens from the array of lenses, the second lens configured to focus at least a portion of the analyte-dependent optical signal onto at least one of the one or more detectors, the second lens defining a second lens axis substantially parallel to and non-coaxial with the first lens axis.

2. The apparatus of claim 1, further comprising:

an aperture, the aperture, the first lens, and at least one of the one or more detectors collectively configured to inhibit a photon having an angle of incidence greater than a predetermined angle of incidence from striking that detector.

3. The apparatus of claim 1, wherein the array of lenses is a monolithically formed array of lenses.

4. The apparatus of claim 1, further comprising:

an array of apertures, each aperture from the array of apertures being substantially aligned with a center of a lens from the array of lenses.

5. The apparatus of claim 1, further comprising:

a filter configured to attenuate optical signals having wavelengths associated with the light source.

6. The apparatus of claim 1, further comprising:

a filter configured to attenuate optical signals having wavelengths associated with the light source, the filter configured to transmit the analyte-dependent optical signal with substantially no attenuation.

7. The apparatus of claim 1, further comprising:

a dichroic filter configured to attenuate optical signals having wavelengths associated with the light source, the dichroic filter configured to blue shift analyte-dependent optical signals towards the wavelength associated with the light source as a function of an angle of incidence, the one or more detectors not being configured to detect a blue-shifted analyte-dependent optical signal.

8. The apparatus of claim 7, wherein a portion of the excitation optical signal is scattered by tissue surrounding the implant, the apparatus further comprising:

an aperture, (1) the aperture, (2) the array of lenses, and (3) the dichroic filter are collectively configured to inhibit the portion of the excitation optical signal from entering the at least one of the one or more detectors.

9. A system including the apparatus of claim 1, the system further comprising:

the implanted sensor configured to be disposed a depth beneath the skin, at least a portion of the detector spaced a lateral distance from the light source, the lateral distance being at least twice the depth.

10. A system including the apparatus of claim 1, the system further comprising:

the implanted sensor configured to be implanted in a body at a depth,

the light source disposed directly above the implanted sensor, at least a portion of the detector a distance from the light source that is at least twice the depth.

11. The apparatus of claim 1, wherein the one or more detectors define an opening, the light source configured to transmit the excitation optical signal to the implanted sensor through the opening.

12. The apparatus of claim 1, wherein:

the one or more detectors include a plurality of detectors; and

the planar base defines an opening, the light source configured to transmit the excitation optical signal to the implanted sensor through the opening, the plurality of detectors coupled to the planar base and substantially surrounding the opening.

13. An apparatus, comprising:

a light source configured to transmit an excitation optical signal to a sensor implanted at a depth of at least 1 mm under a surface of a skin;

a detector configured to detect an analyte-dependent optical signal emitted from the sensor in response to the sensor being illuminated by the excitation optical signal, at least a portion of the detector spaced at least 2 mm from the light source such that at least the portion of the detector is spaced apart from the light source at least twice the depth of the sensor;

a cover configured to be disposed between the detector and the skin, the detector being less than 2 mm from the cover; and

a monolithically formed array of lenses disposed between the cover and the detector, a lens from the monolithically formed array of lenses configured to focus a portion of the analyte-dependent optical signal onto the detector.

14. The apparatus of claim 13, further comprising:

an aperture configured to inhibit a photon having an angle of incidence greater than a predetermined angle of incidence from striking the detector.

15. The apparatus of claim 13, wherein the monolithically formed array of lenses includes a first lens defining a first lens axis and a second lens defining a second lens axis substantially parallel to and non-coaxial with the first lens axis.

16. The apparatus of claim 13, further comprising:

an array of apertures, each aperture from the array of apertures being substantially aligned with a center of a lens from the monolithically formed array of lenses.

17. The apparatus of claim 13, further comprising:

a filter configured to attenuate optical signals having wavelengths associated with the light source.

18. The apparatus of claim 13, further comprising:

a filter configured to attenuate optical signals having wavelengths associated with the light source, the filter configured to transmit the analyte-dependent optical signal with substantially no attenuation.

19. The apparatus of claim 13, further comprising:

a dichroic filter configured to attenuate optical signals having wavelengths associated with the light source, the dichroic filter configured to blue shift analyte-dependent optical signals towards the wavelength associated with the light source as a function of an angle of incidence, the detector not being configured to detect a blue-shifted analyte-dependent optical signal.

20. The apparatus of claim 13, wherein a portion of the excitation optical signal is scattered by tissue surrounding the implant, the apparatus further comprising:

an aperture, (1) the aperture, (2) the monolithically formed array of lenses, and (3) the dichroic filter are collectively configured to inhibit the portion of the excitation optical signal from entering the detector.

21. The apparatus of claim 13, wherein:

the light source is configured to be disposed directly above the sensor.

22. The apparatus of claim 13, wherein the light source is configured to transmit the excitation optical signal through an opening having a first cross-sectional area, and the detector has a second cross-sectional area, the second cross-sectional area being at least four times the first cross-sectional area.

23. The apparatus of claim 13, wherein the detector defines an opening, the light source configured to transmit the excitation optical signal to the sensor through the opening.

24. The apparatus of claim 13, wherein the detector is one of a plurality of detectors, the apparatus further comprising:

a base defining an opening, the light source configured to transmit the excitation optical signal to the sensor through the opening, the plurality of detectors coupled to the base and substantially surrounding the opening.

25. An apparatus, comprising:

a light source configured to transmit an excitation optical signal to an implanted sensor;

a base defining an opening, the light source configured to transmit the excitation optical signal to the implanted sensor through the opening;

one or more detectors coupled to the base and configured to detect an analyte-dependent optical signal emitted from the implanted sensor in response to the implanted sensor being illuminated by the excitation optical signal;

a first lens from an array of lenses, the first lens configured to focus at least a portion of the analyte-dependent optical signal onto the at least one of the one or more detectors, the first lens defining a first lens axis; and

a second lens from the array of lenses, the second lens configured to focus at least a portion of the analyte-dependent optical signal onto at least one of the one or more detectors, the second lens defining a second lens axis substantially parallel to and non-coaxial with the first lens axis.

26. The apparatus of claim 25, wherein the one or more detectors include plurality of detectors coupled to the base and substantially surrounding the opening.

27. The apparatus of claim 25, wherein the base is a printed circuit board.