Apparatus, systems and methods for the treatment of neurological conditions
First Claim
1. A method for preventing or treating an epileptic seizure in a patient, the method comprising:
- detecting an epileptic pre-seizure event or seizure event in the patient'"'"'s brain, wherein detecting an epileptic pre-seizure or seizure includes generating a detection score;
storing doses of a loop diuretic compound in a subcutaneously implanted storage device, the storage device comprising a belt within the storage device to which the doses are attached; and
delivering intra-cranially to the patient'"'"'s brain, a dose of the loop diuretic compound from the belt to prevent or reduce a duration of the epileptic seizure, wherein the delivered dose of the loop diuretic compound is below a threshold, based on a value of the detection score, to cause a significant increase in diuresis, and wherein the delivered dose is titratable based on a measurement of a volume of the patient'"'"'s brain.
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Accused Products
Abstract
Various embodiments described herein provide an apparatus system, and method for detecting and treating various neurological events or conditions such as epilepsy and migraine headaches which are associated with cortical spreading depression (CSD). Also, many embodiments provide an apparatus, system and method for delivery of a drug such as a loop diuretic to prevent or reduce the duration of a seizure or other event associated with CSD. The drug may delivered intra-cranially in a dose selected to produce a localized effect in the brain to prevent or reduce the duration of the seizure or other event while minimizing adverse peripheral effects such as diuresis or electrolyte loss.
24 Citations
37 Claims
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1. A method for preventing or treating an epileptic seizure in a patient, the method comprising:
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detecting an epileptic pre-seizure event or seizure event in the patient'"'"'s brain, wherein detecting an epileptic pre-seizure or seizure includes generating a detection score; storing doses of a loop diuretic compound in a subcutaneously implanted storage device, the storage device comprising a belt within the storage device to which the doses are attached; and delivering intra-cranially to the patient'"'"'s brain, a dose of the loop diuretic compound from the belt to prevent or reduce a duration of the epileptic seizure, wherein the delivered dose of the loop diuretic compound is below a threshold, based on a value of the detection score, to cause a significant increase in diuresis, and wherein the delivered dose is titratable based on a measurement of a volume of the patient'"'"'s brain. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A method for preventing or treating an epileptic seizure in a patient, the method comprising:
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storing doses of a loop diuretic compound in a subcutaneously implanted storage device, the storage device comprising a belt within the storage device to which the doses are attached; detecting an epileptic pre-seizure event or seizure event in the patient'"'"'s brain, wherein detecting an epileptic pre-seizure or seizure includes generating a detection score; and delivering intra-cranially to the patient'"'"'s brain, a dose of the loop diuretic compound from the belt to prevent or reduce a duration of the epileptic seizure, wherein the delivered dose of the loop diuretic compound is below a threshold, based on a value of the detection score, to cause a significant decrease in an electrolyte level of the patient, and wherein the delivered dose is titratable based on a measurement of a volume of the patient'"'"'s brain. - View Dependent Claims (27, 28, 29, 30, 31)
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32. A method for preventing or treating in a patient a neural condition associated with cortical spreading depression, the method comprising:
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storing doses of a loop diuretic compound in a subcutaneously implanted storage device, the storage device comprising a belt within the storage device to which the doses are attached; detecting cortical spreading depression in the patient'"'"'s brain, wherein detecting cortical spreading depression includes generating a detection score; and delivering intra-cranially to the patient'"'"'s brain, a dose of the loop diuretic compound from the belt to prevent, slow or reduce a duration of cortical spreading depression, wherein the delivered dose of the loop diuretic compound is below a threshold, based on a value of the detection score, to cause significant amounts of diuresis, and wherein the delivered dose is titratable based on a measurement of a volume of the patient'"'"'s brain. - View Dependent Claims (33)
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34. A method for preventing or treating an epileptic seizure in a patient, the method comprising:
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storing doses of a loop diuretic compound in a subcutaneously implanted storage device, the storage device comprising a belt to which the doses are attached; detecting an epileptic pre-seizure event or seizure event in the patient'"'"'s brain, wherein detecting an epileptic pre-seizure or seizure includes generating a detection score; and delivering intra-cranially to the patient'"'"'s brain, a dose of the loop diuretic compound from the belt to prevent or reduce a duration of the epileptic seizure, wherein the delivered dose of the loop diuretic compound, based on a value of the detection score, does not cause a significant physiological peripheral effect, and wherein the delivered dose is titratable based on a measurement of a volume of the patient'"'"'s brain. - View Dependent Claims (35, 36, 37)
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Specification