Usage monitoring attachment for medicament dispenser

• US 10,220,166 B2
• Filed: 05/21/2014
• Issued: 03/05/2019
• Est. Priority Date: 05/21/2013
• Status: Active Grant

• Current Assignee: Reciprocal Labs Corporation (ResMed Incorporated)
• Original Assignee: Reciprocal Labs Corporation (ResMed Incorporated)
• Inventors: Van Sickle, John David, Tracy, Greg, Gehring, Mark, Hoffman, Eric, Houlihan, Kevin, Hallberg, Chris
• Primary Examiner(s): Lo, Andrew S
• Application Number:
  US14/770,078
• Publication Number:
  US 20160256639A1
• Time in Patent Office: 1,749 Days
• Field of Search: 12820312
• CPC Class Codes: A61M 15/00 Inhalators drug delivery in endotracheal tubes A61M16/04
• CPC Class Codes: A61M 15/0021 Mouthpieces therefor
• CPC Class Codes: A61M 15/0048 the dosages being arranged in a plane, e.g. on diskettes
• CPC Class Codes: A61M 15/008 Electronic counters
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/3303 Using a biosensor
• CPC Class Codes: A61M 2205/332 Force measuring means
• CPC Class Codes: A61M 2205/3375 Acoustical, e.g. ultrasonic, measuring means
• CPC Class Codes: A61M 2205/3553 remote, e.g. between patient's home and doctor's office
• CPC Class Codes: A61M 2205/3592 using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: G16H 20/13 delivered from dispensers
• CPC Class Codes: G16H 40/67 for remote operation

Abstract

Systems and methods are described for monitoring usage of a medicament dispenser—particularly an inhaled medicament dispenser. While operating in a low-power mode, a first sensor is monitored for a signal indicative of handling of the medicament dispenser by a user. In response to detecting such handling, the device exits the low-power mode and begins to monitor a second sensor for a signal indicative of dispensing of the medicament. The usage monitoring device can be embodied as an attachment configured to be selectively coupled to one of a variety of different inhalers including, for example, a Diskus-type inhaler and a Respimat-type inhaler.

Claims

1. A method of monitoring usage of a medicament dispenser with a monitoring attachment, the method comprising:

detecting with a first sensor of the monitoring attachment a first signal indicative of handling of the medicament dispenser while in a low-power mode;

in response to detecting the first signal, applying power to a second sensor of the monitoring attachment;

detecting with the second sensor a second signal indicative of priming medicament by the medicament dispenser;

in response to detecting the second signal, applying power to a third sensor of the monitoring attachment; and

detecting with the third sensor a third signal indicative of dispensing of medicament by the medicament dispenser.

2. The method of claim 1, wherein the first sensor comprises an acceleration sensor and wherein detecting with the first sensor the first signal indicative of handling of the medicament dispenser while in the low-power mode comprises:

receiving the first signal from the acceleration sensor indicative of an acceleration of the medicament dispenser as detected by the acceleration sensor, and

comparing the first signal to an acceleration threshold; and

determining the first signal to be indicative of handling of the medicament dispenser based on the first signal exceeding the acceleration threshold.

3. The method of claim 1, wherein the first sensor comprises a galvanic skin response sensor, and wherein detecting with the first sensor for the first signal indicative of handling of the medicament dispenser while in the low-power mode comprises receiving the first signal from the galvanic skin response sensor indicative of a contact between the galvanic skin response sensor and a skin surface of a user of the medicament dispenser.

4. The method of claim 1, further comprising transmitting a wireless signal through a wireless transmitter indicative of a detected dispensing of medicament by the medicament dispenser.

5. The method of claim 4, further comprising determining a time and a date of the dispensing of the medicament, and wherein the wireless signal comprises the time and the date of the dispensing.

6. The method of claim 1, wherein the second sensor comprises an infrared (IR) sensor positioned to detect movement of a movable part of the medicament dispenser relative to a body of the medicament dispenser, wherein the second signal comprises detected movement of the movable part relative to the body.

7. The method of claim 6, wherein the movable part comprises a dispensing lever of the medicament dispenser and movement of the dispensing lever relative to the body primes medicament for dispensing by the medicament dispenser.

8. The method of claim 6, wherein the movable part comprises a cover of the medicament dispenser and movement of the cover relative to the body reveals an orifice of the medicament dispenser through which the medicament is dispensed by the medicament dispenser.

9. The method of claim 1, wherein the third sensor comprises a microphone and wherein detecting with the third sensor the third signal indicative of dispensing of the medicament by the medicament dispenser comprises receiving from the microphone the third signal corresponding to a sound of an inhalation of medicament dispensed by the medicament dispenser.

10. The method of claim 9, further comprising:

recording the third signal from the microphone; and

transmitting the recording through a wireless transmitter to a remote computer system for analysis.

11. The method of claim 1, wherein the second sensor comprises a microphone and wherein detecting with the second sensor for the second signal indicative of priming of the medicament of the medicament dispenser comprises receiving from the microphone the second signal corresponding to a sound of a priming action by the medicament dispenser.

12. The method of claim 8, wherein the monitoring attachment is coupled to the cover and does not affect movement of the cover relative to the body.

13. A monitoring attachment coupled to a medicament dispenser for monitoring usage of the medicament dispenser, the monitoring attachment comprising:

a housing comprising an exterior surface coupleable to a cover of the medicament dispenser, wherein the monitoring attachment does not affect operation of the medicament dispenser;

a first sensor fixedly coupled to the housing, configured to detect a first signal indicative of handling of the medicament dispenser;

a second sensor fixedly coupled to an exterior of the housing and positioned to detect movement of the cover relative a body of the medicament dispenser, configured to detect a second signal indicative of priming of the medicament dispenser;

a third sensor coupled to the exterior of the housing, configured to detect a third signal indicative of dispensing of medicament by the medicament dispenser;

a processor; and

a non-transitory computer-readable memory storing instructions that, when executed by the processor, cause the processor to;

operate in a low-power mode where power is applied to the first sensor but not applied to the second sensor and not applied to the third sensor,

monitor the first sensor for the first signal,

in response to detecting the first signal, apply power to the second sensor but not to the third sensor,

monitor the second sensor for the second signal,

in response to detecting the second signal, apply power to the third sensor, and

monitor the third sensor for the third signal.

14. The monitoring attachment of claim 13, wherein the exterior of the housing is substantially disc-shaped and coupleable to the cover of the medicament dispenser which is substantially disc-shaped, the substantially disc-shaped cover being rotatable relative to the body which is also substantially disc-shaped, wherein a rotation of the cover relative to the body exposes an orifice of the medicament dispenser through which medicament is dispensed by the medicament dispenser.

15. The monitoring attachment of claim 13, wherein the housing further comprises:

one or more side support structures which are sized to receive a majority of the cover of the medicament dispenser.

16. The monitoring attachment of claim 13, wherein the first sensor comprises an acceleration sensor and wherein the instructions to monitor the first sensor for the first signal comprise additional instructions, that when executed by the processor, cause the processor to:

receive the first signal from the acceleration sensor indicative of an acceleration of the medicament dispenser as detected by the acceleration sensor;

compare the first signal to an acceleration threshold; and

determine the first signal to be indicative of handling of the medicament dispenser based on the first signal exceeding the acceleration threshold.

17. The monitoring attachment of claim 13, wherein the first sensor comprises a galvanic skin response sensor and wherein the instructions to monitor the first sensor for the first signal comprise additional instructions, that when executed by the processor, cause the processor to:

receive the first signal from the galvanic skin response sensor indicative of a contact between the galvanic skin response sensor and a skin surface of a user of the medicament dispenser.

18. The monitoring attachment of claim 13, wherein the second sensor comprises an IR sensor.

19. The monitoring attachment of claim 13, wherein the third sensor comprises a microphone, wherein the third signal comprises a sound of an inhalation of medicament dispensed by the medicament dispenser.

20. The monitoring attachment of claim 13, further comprising:

a wireless transmitter coupled within the housing and configured to transmit the third signal to a remote computer device; and

wherein the non-transitory computer-readable memory comprises additional instructions that, when executed by the processor, cause the processor to;

transmit the third signal from through the wireless transmitter to the remote computer device.

21. A non-transitory computer-readable storage medium storing instructions for monitoring usage of a medicament dispenser with a monitoring attachment, the instructions that, when executed by a processor, cause the processor to:

detect with a first sensor of the monitoring attachment a first signal indicative of handling of the medicament dispenser while in a low-power mode;

in response to detecting the first signal, apply power to a second sensor of the monitoring attachment;

detect with the second sensor a second signal indicative of priming medicament by the medicament dispenser;

in response to detecting the second signal, apply power to a third sensor of the monitoring attachment; and

detect with the third sensor a third signal indicative of a dispensing of medicament by the medicament dispenser.

22. The storage medium of claim 21, wherein the first sensor comprises an acceleration sensor and wherein detect with the first sensor the first signal indicative of handling of the medicament dispenser while in the low-power mode comprises:

receive the first signal from the acceleration sensor indicative of an acceleration of the medicament dispenser as detected by the acceleration sensor, and

compare the first signal to an acceleration threshold; and

determine the first signal to be indicative of handling of the medicament dispenser based on the first signal exceeding the acceleration threshold.

23. The storage medium of claim 21, wherein the first sensor comprises a galvanic skin response sensor, and wherein detect with the first sensor for the first signal indicative of handling of the medicament dispenser while in the low-power mode comprises:

receive the first signal from the galvanic skin response sensor indicative of a contact between the galvanic skin response sensor and a skin surface of a user of the medicament dispenser.

24. The storage medium of claim 21, storing further instructions that, when executed by the processor, cause the processor to transmit a wireless signal through a wireless transmitter indicative of a detected dispensing of medicament by the medicament dispenser.

25. The storage medium of claim 24, storing further instructions that, when executed by the processor, cause the processor to determine a time and a date of the dispensing of the medicament, and wherein the wireless signal comprises the time and the date of the dispensing.

26. The storage medium of claim 21, wherein the second sensor comprises an infrared (IR) sensor positioned to detect movement of a movable part of the medicament dispenser relative to a body of the medicament dispenser, wherein the second signal comprises detected movement of the movable part relative to the body.

27. The storage medium of claim 26, wherein the movable part comprises a dispensing lever of the medicament dispenser and movement of the dispensing lever relative to the body primes medicament for dispensing by the medicament dispenser.

28. The storage medium of claim 26, wherein the movable part comprises a cover of the medicament dispenser and movement of the cover relative to the body reveals an orifice of the medicament dispenser through which the medicament is dispensed by the medicament dispenser.

29. The storage medium of claim 28, wherein the monitoring attachment is coupled to the cover and does not affect movement of the cover relative to the body.

30. The storage medium of claim 21, wherein the third sensor comprises a microphone and wherein detect with the third sensor the third signal indicative of dispensing of the medicament by the medicament dispenser comprises:

receive from the microphone the third signal corresponding to a sound of an inhalation of medicament dispensed by the medicament dispenser.

31. The storage medium of claim 30, storing further instructions that, when executed by the processor, cause the processor to:

record the third signal from the microphone; and

transmit the recording through a wireless transmitter to a remote computer system for analysis.

32. The storage medium of claim 21, wherein the second sensor comprises a microphone and wherein detect with the second sensor for the second signal indicative of priming of the medicament of the medicament dispenser comprises:

receive from the microphone the second signal corresponding to a sound of a priming action by the medicament dispenser.