5-position modified pyrimidines and their use

• US 10,221,207 B2
• Filed: 07/14/2017
• Issued: 03/05/2019
• Est. Priority Date: 04/12/2010
• Status: Active Grant

• Current Assignee: SomaLogic Operating Co., Inc. (Somalogic Incorporated)
• Original Assignee: Somalogic Incorporated
• Inventors: Rohloff, John, Janjic, Nebojsa, Carter, Jeffrey D., Fowler, Catherine
• Primary Examiner(s): Balasubramanian, Venkataraman
• Application Number:
  US15/650,281
• Publication Number:
  US 20180127450A1
• Time in Patent Office: 599 Days
• Field of Search: 546 2614, 546 262, 546 2621
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/04 Antipruritics
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07H 19/06 Pyrimidine radicals
• CPC Class Codes: C07H 19/10 with the saccharide radical esterified by phosphoric or polyphosphoric acids
• CPC Class Codes: C07H 21/04 with deoxyribosyl as saccharide radical
• CPC Class Codes: C12N 15/115 Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
• CPC Class Codes: C12N 2310/335 Modified T or U

Abstract

The present disclosure relates to the field of nucleic acid chemistry, specifically to 5-position modified uridines as well as phosphoramidite and triphosphate derivatives thereof. The present disclosure also relates to methods of making and using the same.

Claims

1. A C-5 modified aminocarbonylpyrimidine having the following structure:

2. A 3′

-phosporamidite of a C-5 modified aminocarbonylpyrimidine having the following structure;

3. A 5′

-triphosphate of a C-5 modified aminocarbonylpyrimidine having the following structure;