Systems and methods for measuring neonatal cerebral oxygenation
First Claim
1. A neonatal cerebral oxygenation monitoring apparatus comprising:
- a wearable support sized and configured to cover at least a portion of a head of an infant to be secured thereto, the wearable support comprising a posterior portion configured to be placed over a posterior portion of the infant'"'"'s head when the wearable support is secured to the head of the infant;
a light emitter positioned on the posterior portion of the wearable support so that the light emitter faces and emits toward a superior sagittal sinus of the infant'"'"'s head when the wearable support is secured onto the infant'"'"'s head; and
an acoustic sensor positioned on the posterior portion of the wearable support so that the acoustic sensor faces the posterior portion of the head of the infant to detect acoustic pressure generated by blood in the superior sagittal sinus when the superior sagittal sinus blood absorbs the light,wherein cerebral blood oxygenation is determined in response to the acoustic pressure detected by the acoustic sensor, and wherein the light emitter is configured to emit the light through a posterior fontanelle of the infant'"'"'s head, and wherein the acoustic sensor is configured to detect the acoustic pressure through the posterior fontanelle.
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Accused Products
Abstract
Disclosed herein are systems and methods for monitoring one or more of cerebral oxygenation and total hemoglobin concentration that can be used to perform accurate, noninvasive measurement of cerebral venous blood oxygen saturation (oxygenation) in neonatal patients. A neonatal cerebral oxygenation detection apparatus comprises a wearable support having a light emitter and an acoustic sensor coupled thereto. The wearable support can be secured onto a head of an infant, and the light emitter can be configured to emit a light toward a superior sagittal sinus of the infant'"'"'s head. The acoustic sensor can be configured to detect acoustic pressure generated by blood in the superior sagittal sinus when the superior sagittal sinus blood absorbs the light. Cerebral oxygenation and/or total hemoglobin concentration can be determined based on the acoustic pressure detected by the acoustic detector.
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Citations
23 Claims
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1. A neonatal cerebral oxygenation monitoring apparatus comprising:
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a wearable support sized and configured to cover at least a portion of a head of an infant to be secured thereto, the wearable support comprising a posterior portion configured to be placed over a posterior portion of the infant'"'"'s head when the wearable support is secured to the head of the infant; a light emitter positioned on the posterior portion of the wearable support so that the light emitter faces and emits toward a superior sagittal sinus of the infant'"'"'s head when the wearable support is secured onto the infant'"'"'s head; and an acoustic sensor positioned on the posterior portion of the wearable support so that the acoustic sensor faces the posterior portion of the head of the infant to detect acoustic pressure generated by blood in the superior sagittal sinus when the superior sagittal sinus blood absorbs the light, wherein cerebral blood oxygenation is determined in response to the acoustic pressure detected by the acoustic sensor, and wherein the light emitter is configured to emit the light through a posterior fontanelle of the infant'"'"'s head, and wherein the acoustic sensor is configured to detect the acoustic pressure through the posterior fontanelle. - View Dependent Claims (2, 3, 4)
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5. A neonatal cerebral oxygenation monitoring apparatus comprising:
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a wearable support sized and configured to cover at least a portion of a head of an infant to be secured thereto, the wearable support comprising a superior portion configured to be placed over a superior portion of the infant'"'"'s head when the wearable support is secured to the head of the infant; a light emitter positioned on the superior portion of the wearable support so that the light emitter faces and emits light toward a superior sagittal sinus of the infant'"'"'s head when the wearable support is secured onto the infant'"'"'s head; an acoustic sensor positioned on the superior portion of the wearable support so that the acoustic sensor faces the superior portion of the head of the infant to detect acoustic pressure generated by blood in the superior sagittal sinus when the superior sagittal sinus blood absorbs the light, wherein cerebral blood oxygenation is determined in response to the acoustic pressure detected by the acoustic sensor, and wherein the light emitter is configured to emit the light through an anterior fontanelle of the infant'"'"'s head, and wherein the acoustic sensor is configured to detect the acoustic pressure through the anterior fontanelle. - View Dependent Claims (6, 7, 8, 9, 10, 11)
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12. A method for monitoring one or more of cerebral oxygenation or total hemoglobin concentration of an infant, the method comprising:
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emitting light from a light emitter secured to a head of the infant with a wearable support secured onto the infant'"'"'s head, wherein the wearable support is sized and configured to cover at least a portion of the infant'"'"'s head to be secured thereto, and wherein the light emitter is positioned on the wearable support so the light emitter faces and emits light toward a superior sagittal sinus of the infant'"'"'s head through a fontanelle; detecting, with an acoustic sensor secured to the infant'"'"'s head with the wearable support, acoustic pressure generated by blood in the superior sagittal sinus in response to the emitted light, wherein the acoustic sensor is positioned on the wearable support to face the superior sagittal sinus to detect the acoustic pressure generated therefrom through the fontanelle; and determining, with a processor in communication with the light emitter and the acoustic, one or more of cerebral venous blood oxygenation or total hemoglobin concentration in response to the detected acoustic pressure. - View Dependent Claims (13, 14, 15, 16, 17)
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18. A method for monitoring one or more of cerebral oxygenation or total hemoglobin concentration of an infant, the method comprising:
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(A) securing a wearable support onto a head of the infant, the wearable support being sized and configured to cover at least a portion of the infant'"'"'s head to be secured thereto, wherein securing the wearable support comprises; (i) positioning a light emitter coupled to the wearable support so that the light emitter faces and emits light toward a superior sagittal sinus of the infant'"'"'s head through a fontanelle, and (ii) positioning an acoustic sensor coupled to the wearable support so that the acoustic sensor faces the superior sagittal sinus to detect acoustic pressure generated by blood therein through the fontanelle when the superior sagittal sinus blood absorbs the light; (B) causing the light to be emitted from the light emitter; (C) causing the acoustic pressure to be detected by the acoustic sensor; and (D) determining, with the aid of a processor in communication with the light emitter and the acoustic sensor, cerebral oxygenation in response to the detected acoustic pressure. - View Dependent Claims (19, 20, 21, 22, 23)
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Specification