Diagnostic and monitoring electrical impedance tomography (EIT) system for osteoporosis
First Claim
1. A method of measuring Bone Mineral Density (BMD) comprising:
- providing an Electrical Impedance Tomography (EIT) conductivity distribution model of a plurality of constituents of at least a portion of a subject body, the model comprising at least one bone constituent;
injecting electric current into the portion of the subject body using a current injection electrode, such that at least part of the current flows through the at least one bone constituent;
measuring a value of electric potential at a surface of the subject body using a pickup electrode;
using a value of the injected electric current as input to the EIT model of the at least a portion of the subject body; and
calculating a value of conductance of the bone constituent corresponding to a value of the injected electric current and the measured value of the electric potential, the calculating comprising using the EIT conductivity distribution model including at least a bone conductivity value and a value for non-bone tissue conductivity; and
calculating a patient'"'"'s Bone Mineral Density (BMD) based on the value of conductance of the bone constituent,in which the calculating a value of conductance of the bone constituent includes;
(a) providing an initial bone conductivity value for use as a bone conductivity value for bone being measured;
(b) generating said conductivity distribution model including the bone conductivity value and including the values for non-bone tissue conductivity;
(c) forward calculating a value of electric potential at the pickup electrode;
(d) minimizing a difference between the value calculated according to step (c) and the value of electric potential measured at the pickup electrode by adjusting the bone conductivity value; and
(e) calculating a value of conductance of the bone constituent based on the adjusted bone conductivity value.
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Accused Products
Abstract
A method of measuring Bone Mineral Density (BMD) including providing a model of a plurality of constituents of at least a portion of a subject body, the model including at least one bone constituent, injecting electric current into the portion of the subject body using a current injection electrode, such that at least part of the current flows through the at least one bone constituent, measuring a value of electric potential at a surface of the subject body using a pickup electrode, using a value of the injected electric current as input to a model of the at least a portion of a subject body, and calculating a value of conductance of the bone constituent corresponding to a value of the injected electric current and the measured value of the electric potential. Related apparatus and methods are also described.
17 Citations
18 Claims
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1. A method of measuring Bone Mineral Density (BMD) comprising:
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providing an Electrical Impedance Tomography (EIT) conductivity distribution model of a plurality of constituents of at least a portion of a subject body, the model comprising at least one bone constituent; injecting electric current into the portion of the subject body using a current injection electrode, such that at least part of the current flows through the at least one bone constituent; measuring a value of electric potential at a surface of the subject body using a pickup electrode; using a value of the injected electric current as input to the EIT model of the at least a portion of the subject body; and calculating a value of conductance of the bone constituent corresponding to a value of the injected electric current and the measured value of the electric potential, the calculating comprising using the EIT conductivity distribution model including at least a bone conductivity value and a value for non-bone tissue conductivity; and calculating a patient'"'"'s Bone Mineral Density (BMD) based on the value of conductance of the bone constituent, in which the calculating a value of conductance of the bone constituent includes; (a) providing an initial bone conductivity value for use as a bone conductivity value for bone being measured; (b) generating said conductivity distribution model including the bone conductivity value and including the values for non-bone tissue conductivity; (c) forward calculating a value of electric potential at the pickup electrode; (d) minimizing a difference between the value calculated according to step (c) and the value of electric potential measured at the pickup electrode by adjusting the bone conductivity value; and (e) calculating a value of conductance of the bone constituent based on the adjusted bone conductivity value. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A system for measuring Bone Mineral Density (BMD) comprising:
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a computational unit which includes an Electrical Impedance Tomography (EIT) conductivity distribution model of a plurality of constituents of at least a portion of a subject, the model comprising at least one bone constituent; an injection electrode for injecting electric current into the portion of the subject, such that at least part of the current flows through the at least one bone constituent; a pickup electrode for measuring a value of electric potential at a surface of the subject; wherein the computational unit; receives input of what value of the injected electric current is injected into the portion of the subject; receives input of a measured value of electric potential at the surface of the subject; uses the value of the injected electric current for input to the model; and calculates a value of conductance of the bone constituent corresponding to the value of the injected electric current and the measured value of the electric potential, the calculating comprising using the EIT conductivity distribution model including a bone conductivity value and a value for non-bone tissue conductivity; and calculating a patient'"'"'s Bone Mineral Density (BMD) based on the value of conductance of the bone constituent, in which the calculating a value of conductance of the bone constituent includes; (a) providing an initial bone conductivity value for use as a bone conductivity value for bone being measured; (b) generating said conductivity distribution model including the bone conductivity value and including the values for non-bone tissue conductivity; (c) forward calculating a value of electric potential at the pickup electrode; (d) minimizing a difference between the value calculated according to step (c) and the value of electric potential measured at the pickup electrode by adjusting the bone conductivity value; and (e) calculating a value of conductance of the bone constituent based on the adjusted bone conductivity value. - View Dependent Claims (14, 15, 16, 17, 18)
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Specification