Methods for modifying vascular vessel walls

• US 10,226,256 B2
• Filed: 02/04/2014
• Issued: 03/12/2019
• Est. Priority Date: 12/07/2004
• Status: Active Grant

• Current Assignee: Cook Biotech Incorporated (Cook Group Incorporated)
• Original Assignee: Cook Biotech Incorporated (Cook Group Incorporated), Cook Medical Incorporated (Cook Group Incorporated)
• Inventors: Case, Brian C., Flagle, Jacob A., Hiles, Michael C., Patel, Umesh H., Obermiller, F. Joseph
• Primary Examiner(s): Mathew, Seema
• Application Number:
  US14/172,243
• Publication Number:
  US 20140228933A1
• Time in Patent Office: 1,862 Days
• CPC Class Codes: A61B 17/12 for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord specially adapted for vas deferens or fallopian tubes A61F6/20; materials for ligaturing blood vessels A61L17/00
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/2475 Venous valves
• CPC Class Codes: A61F 2002/075 the stent being loosely attached to the graft material, e.g. by stitching
• CPC Class Codes: A61F 2002/077 having means to fill the space between stent-graft and aneurysm wall, e.g. a sleeve
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system

Abstract

This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.

Claims

1. A method of treating a vascular vessel of a patient, the method comprising:

accessing a treatment site proximate to a defect in a vascular vessel;

placing a remodelable biomaterial in contact with an exterior of a vessel wall at the treatment site;

placing a reinforcing clamp around said biomaterial to provide further support or compress against the external side walls of said vascular vessel; and

wherein said defect is an aneurysm or distention of the vessel wall, and wherein the remodelable biomaterial is effective to shrink after implantation so as to modify the shape of and support the vessel wall at the treatment site.

2. The method of claim 1, wherein said remodelable biomaterial is placed so as to partially or fully encircle the exterior of a vessel wall at the treatment site.

3. The method of claim 1, wherein said remodelable biomaterial is sutured or secured to the external circumference of the target vessel overlaying the treatment site.

4. The method of claim 1, wherein opposite ends of said remodelable biomaterial touch or overlap each other.

5. The method of claim 1, wherein two portions of said remodelable biomaterial are secured together.

6. The method of claim 5, wherein the two portions of said remodelable biomaterial are secured together by suturing, tissue welding, the use of bonding agents, or the use of fibrin glue.

7. The method of claim 1, wherein said placing a remodelable biomaterial in contact with an exterior of a vessel wall at the treatment site is performed so as to withstand the dynamic fluid pressure of said vascular vessel.

8. The method of claim 7, wherein said remodelable biomaterial is placed so as to partially or fully encircle the exterior of a vessel wall at the treatment site.

9. The method of claim 7, wherein said remodelable biomaterial is sutured or secured to the external circumference of the target vessel overlaying the treatment site.

10. The method of claim 7, wherein opposite ends of said remodelable biomaterial touch or overlap each other.

11. The method of claim 1, wherein said placing a remodelable biomaterial in contact with an exterior of a vessel wall at the treatment site is performed so as to increase the burst strength of said vascular vessel.

12. The method of claim 11, wherein opposite ends of said remodelable biomaterial touch or overlap each other.

13. The method of claim 1, wherein said aneurysm is not at a site of a vascular valve.

14. The method of claim 1, wherein the aneurysm is a saccular, fusiform or dissecting aneurysm.

15. The method of claim 1, wherein opposite ends of said remodelable biomaterial touch or overlap each other.

16. A method of treating a vascular vessel of a patient, the method comprising:

accessing a treatment site proximate to a defect in a vascular vessel;

placing a remodelable biomaterial in contact with an exterior of a vessel wall at the treatment site; and

wherein said defect is an aneurysm or distention of the vessel wall, and wherein the remodelable biomaterial is effective to shrink after implantation as a result of remodeling so as to modify the shape of and support the vessel wall at the treatment site.

17. The method of claim 16, wherein opposite ends of said remodelable biomaterial touch and overlap each other with a slot and tab configuration.

18. A method of treating a vascular vessel of a patient, the method comprising:

accessing a treatment site proximate to a defect in a vascular vessel;

placing a remodelable biomaterial in contact with an exterior of a vessel wall at the treatment site; and

wherein said defect is an aneurysm or distention of the vessel wall, and wherein the remodelable biomaterial is effective to shrink after implantation so as to modify the shape of and support the vessel wall at the treatment site, and wherein said remodelable biomaterial is a multilaminate remodelable biomaterial.