Ocular pressure regulation

• US 10,226,380 B2
• Filed: 05/26/2016
• Issued: 03/12/2019
• Est. Priority Date: 11/14/2003
• Status: Active Grant

• Current Assignee: Alcon Incorporated
• Original Assignee: Novartis Ag
• Inventors: Coroneo, Minas Theodore
• Primary Examiner(s): Deak, Leslie
• Application Number:
  US15/165,759
• Publication Number:
  US 20160346125A1
• Time in Patent Office: 1,020 Days
• Field of Search: 604 8, 604 9, 604264, 623 41, 623 612, 606107, 606108
• CPC Class Codes: A61F 2/148 Implantation instruments specially adapted therefor
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002

Abstract

Disclosed are devices and methods of treating an ocular disorder including forming a self-sealing incision in a cornea into an anterior chamber of an eye; introducing through the incision a fluid drainage tube having a distal end, a proximal end and a longitudinal, internal lumen extending through the fluid drainage tube, wherein at least the proximal end passes through the anterior chamber; and implanting the distal end of the fluid drainage tube in fluid communication with the suprachoroidal space such that the proximal end of the fluid drainage tube remains in fluid communication with the anterior chamber.

Claims

1. A method of treating an ocular disorder, comprising:

providing an implant having a distal end, a proximal end and a longitudinal, internal lumen extending through the ophthalmic implant and wherein the distal end of the implant includes a round, foldable plate adapted to locate the device on the inner surface of a sclera of the eye;

rolling up at least a portion of the implant to form a rolled up implant;

introducing the rolled up implant into a cannula;

forming an opening in a cornea into the anterior chamber of an eye;

filling the anterior chamber with a viscoelastic substance;

introducing the implant via the cannula through the opening, wherein at least the proximal end of the implant passes through the anterior chamber;

forming previously non-existing space in the eye by separating at least a portion of the ciliary body from at least a portion of the sclera from within the anterior chamber to form the space;

implanting the distal end of the implant in communication with the space; and

permitting aqueous humour to flow through the internal lumen from the anterior chamber towards the space.

2. A method as in claim 1, wherein the implant comprises a tube.

3. A method as in claim 1, wherein the space comprises at least a portion of the suprachoroidal space.

4. A method as in claim 1, wherein forming a previously non-existing space in the eye comprises performing a cyclodialysis.

5. A method as in claim 4, further comprising inserting viscoelastic to further form the space.

6. A method as in claim 5, wherein inserting the viscoelastic comprises inserting viscoelastic through an attachment between the ciliary body and the sclera.

7. A method as in claim 6, wherein inserting the viscoelastic comprises enlarging an area of detachment of the ciliary body from the sclera.

8. A method as in claim 7, wherein the space extends into the suprachoroidal space.

9. A method as in claim 1, wherein the proximal end of the implant remains in fluid communication with the anterior chamber.

10. A method as in claim 1, wherein introducing through the opening an ophthalmic implant comprises introducing the entire ophthalmic implant into the anterior chamber of the eye.

11. A method as in claim 10, wherein introducing the entire ophthalmic implant into the anterior chamber of the eye comprises passing the distal end and the proximal end of the ophthalmic implant through the cornea.

12. A method as in claim 1, wherein introducing through the incision an ophthalmic implant comprises placing the ophthalmic implant in the eye after forming the space.

13. A method as in claim 1, wherein forming an opening comprises creating a self-sealing incision in the cornea 180 degrees away from a planned insertion site of the ophthalmic implant in the eye.

14. A method as in claim 1, wherein the incision is formed in the limbus of the cornea.

15. A method as in claim 1, further comprising injecting a viscoelastic substance into the anterior chamber of the eye prior to introducing the ophthalmic implant through the opening.

16. A method as in claim 1, wherein aqueous pressure of the eye is maintained at a pressure of not less than 10 mmHg.