Drug delivery systems and applications
First Claim
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1. A medical material comprisinga biodegradable hydrophilic hydrogel comprising dispersed lipophilic microparticles that have a diameter from 1-500 microns and consist essentially of a low water soluble lipophilic compound that has a solubility in 20°
- C. distilled water that is from 0.001 to 0.5 mg/ml and a therapeutic protein having a secondary and/or a tertiary structure disposed as a solid particle of less than 20 microns diameter in the microparticles, with the microparticles having no more than 4 parts of the lipophilic compound for every one part of the therapeutic protein on a w/w basis, with the particle releasing 100% the protein in less than 24 hours in the absence of the hydrogel upon exposure to physiological solution.
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Abstract
Certain embodiments of the invention include medical materials and methods comprising a biodegradable hydrophilic hydrogel comprising dispersed lipophilic particles that comprise a therapeutic agent, wherein the lipophilic particles have a low water solubility in physiological saline at physiological temperature.
389 Citations
40 Claims
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1. A medical material comprising
a biodegradable hydrophilic hydrogel comprising dispersed lipophilic microparticles that have a diameter from 1-500 microns and consist essentially of a low water soluble lipophilic compound that has a solubility in 20° - C. distilled water that is from 0.001 to 0.5 mg/ml and a therapeutic protein having a secondary and/or a tertiary structure disposed as a solid particle of less than 20 microns diameter in the microparticles, with the microparticles having no more than 4 parts of the lipophilic compound for every one part of the therapeutic protein on a w/w basis, with the particle releasing 100% the protein in less than 24 hours in the absence of the hydrogel upon exposure to physiological solution.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 31, 32, 33, 34, 35, 36, 37, 38, 40)
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13. A process of making a medical material comprising
coating a protein powder with a low water soluble lipophilic compound that, has a solubility in 20° - C. distilled water that is from 0.001 to 0.5 mg/ml to make microparticles that have a diameter from 1-500 microns and that consist essentially of the protein disposed as a solid particle of less than 20 microns diameter in the microparticles and the low water soluble lipophilic compound, with the microparticles having no more than 4 parts of the lipophilic compound for every one part of the therapeutic protein on a w/w basis, with the particle releasing 100% the protein in less than 24 hours upon exposure to physiological solution and
dispersing the particles in a medical hydrogel implant, and with the protein having a secondary and/or a tertiary structure. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 39)
- C. distilled water that is from 0.001 to 0.5 mg/ml to make microparticles that have a diameter from 1-500 microns and that consist essentially of the protein disposed as a solid particle of less than 20 microns diameter in the microparticles and the low water soluble lipophilic compound, with the microparticles having no more than 4 parts of the lipophilic compound for every one part of the therapeutic protein on a w/w basis, with the particle releasing 100% the protein in less than 24 hours upon exposure to physiological solution and
Specification