Arrangement and method for determining a stopper position

• US 10,226,578 B2
• Filed: 03/13/2017
• Issued: 03/12/2019
• Est. Priority Date: 07/11/2012
• Status: Active Grant

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: Nagel, Thomas, Richter, Rene, Witt, Robert, Guenther, Richard, Vogel, Johannes
• Primary Examiner(s): Pihulic, Daniel
• Application Number:
  US15/456,960
• Publication Number:
  US 20170182251A1
• Time in Patent Office: 729 Days
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/3375 Acoustical, e.g. ultrasonic, measuring means
• CPC Class Codes: A61M 2205/3389 Continuous level detection A61M2205/3393 takes precedence
• CPC Class Codes: A61M 5/1684 by detecting the amount of infusate remaining, e.g. signalling end of infusion
• CPC Class Codes: A61M 5/315 Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
• CPC Class Codes: A61M 5/31568 Means keeping track of the total dose administered, e.g. since the cartridge was inserted
• CPC Class Codes: G01F 11/029 provided with electric controlling means G01F11/022 and G01F11/024 take precedence
• CPC Class Codes: G01F 17/00 Methods or apparatus for determining the capacity of containers or cavities, or the volume of solid bodies measuring linear dimensions to determine volume G01B
• CPC Class Codes: G01F 22/00 Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for
• CPC Class Codes: G01S 15/36 with phase comparison between the received signal and the contemporaneously transmitted signal
• CPC Class Codes: G01S 15/88 Sonar systems specially adapted for specific applications seismic or acoustic prospecting or detecting G01V1/00

Abstract

An arrangement for determining a position (x) of a stopper relative to a container in a drug delivery device includes an acoustic source configured to emit an acoustic signal and an acoustic sensor configured to detect an acoustic signal, a processing unit for controlling the acoustic source and processing the detected acoustic signal for determining characteristics of the acoustic signal correlated with the position (x) of the stopper. A method for determining a position (x) of a stopper relative to a container in a drug delivery device includes the steps of emitting an acoustic signal from an acoustic source, detecting an acoustic signal caused by the emitted acoustic signal by means of an acoustic sensor, and processing the detected acoustic signal for determining characteristics of the acoustic signal correlated with the position (x) of the stopper by means of a processing unit.

Claims

1. A drug delivery device comprising:

a container comprising a cavity configured to contain a drug;

a stopper positioned in the cavity, the stopper configured to displace the drug from the cavity;

an acoustic source;

an acoustic sensor; and

a processing unit coupled to the acoustic source and the acoustic sensor, the processing unit configured to;

control the acoustic source to emit an acoustic signal into the cavity;

control the acoustic sensor to detect a reflected acoustic signal responsive to the acoustic signal; and

determine a position of the stopper in the cavity based on the acoustic signal and the reflected acoustic signal.

2. The drug delivery device of claim 1, wherein the processing unit is configured to:

control the acoustic source to emit the acoustic signal onto the stopper through a proximal end of the container;

control the acoustic sensor to detect the reflected acoustic signal reflected by the stopper; and

determine the position of the stopper in the cavity based on a delay or phase shift of the reflected acoustic signal with respect to the acoustic signal.

3. The drug delivery device of claim 1, wherein the acoustic signal and the reflected acoustic signal have an ultrasonic frequency.

4. The drug delivery device of claim 1, wherein the acoustic signal and the reflected acoustic signal have a frequency that is non-audible to a human ear.

5. The drug delivery device of claim 1, wherein the processing unit is configured to determine the position of the stopper in the cavity based on a resonance caused by the acoustic signal and the reflected acoustic signal between a proximal end of the container and the stopper.

6. The drug delivery device of claim 5, wherein the processing unit is configured to control the acoustic source to emit the acoustic signal with a plurality of frequencies varying within a frequency band, wherein the processing unit is configured to determine the position of the stopper by analyzing the reflected acoustic signal to determine a maximum amplitude and a resonance frequency within the frequency band.

7. The drug delivery device of claim 6, wherein the frequency band is selected to match at least part of a range of linear frequency response of the acoustic source.

8. The drug delivery device of claim 5, further comprising a tube section positioned proximally adjacent the container, a diameter of the tube section being substantially equal to an internal diameter of the container.

9. The drug delivery device of claim 5, wherein the processing unit is configured to detect a harmonic of a resonance frequency associated with the position of the stopper in the cavity.

10. A method comprising:

directing an acoustic signal into a cavity defined by a proximal end of a container and a stopper positioned in the cavity, the cavity configured to contain a drug, the stopper configured to displace the drug from the cavity;

detecting a reflected acoustic signal responsive to the acoustic signal; and

determining a position of the stopper in the cavity based on the acoustic signal and the reflected acoustic signal.

11. The method of claim 10, wherein the acoustic signal and the reflected acoustic signal have an ultrasonic frequency.

12. The method of claim 10, wherein the acoustic signal and the reflected acoustic signal have a frequency that is non-audible to a human ear.

13. The method of claim 10, wherein determining the position of the stopper in the cavity based on the acoustic signal and the reflected acoustic signal comprises determining the position of the stopper in the cavity based on a resonance caused by the acoustic signal and the reflected acoustic signal between the proximal end of the container and the stopper.

14. The method of claim 13, further comprising:

emitting the acoustic signal with a plurality of frequencies varying within a frequency band; and

determining the position of the stopper by analyzing the reflected acoustic signal to determining a maximum amplitude and a resonance frequency within the frequency band.

15. The method of claim 14, wherein the frequency band is selected to match at least part of a range of linear frequency response of an acoustic source of the acoustic signal.

16. The method of claim 10, wherein determining the position of the stopper in the cavity based on the acoustic signal and the reflected acoustic signal comprises detecting a harmonic of a resonance frequency associated with the position of the stopper in the cavity.

17. A drug delivery device comprising:

a container comprising a cavity configured to contain a drug;

a stopper positioned in the cavity, the stopper configured to displace the drug from the cavity;

an acoustic source configured to emit an acoustic signal into a region of the cavity between a proximal end of the container and the stopper;

an acoustic sensor configured to detect a reflected acoustic signal responsive to the acoustic signal; and

a processing unit coupled to the acoustic source and the acoustic sensor, the processing unit configured to determine a position of the stopper in the cavity based on the acoustic signal and the reflected acoustic signal.

18. The drug delivery device of claim 17, wherein the processing unit is configured to determine the position of the stopper in the cavity based on a resonance caused by the acoustic signal and the reflected acoustic signal between a proximal end of the container and the stopper.

19. The drug delivery device of claim 17, wherein the processing unit is configured to detect a harmonic of a resonance frequency associated with the position of the stopper in the cavity.

20. The drug delivery device of claim 17, wherein the acoustic source and the acoustic sensor are arranged as a single sound converter configured to emit the acoustic signal, and, after lapse of a pre-determined time window, detect the reflected acoustic signal.