Devices for injection and dosing

• US 10,226,585 B2
• Filed: 09/14/2015
• Issued: 03/12/2019
• Est. Priority Date: 10/01/2014
• Status: Active Grant

• Current Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Original Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Inventors: Franklin, Ethan, Stroumpoulis, Dimitrios, Dominguez, Zachary, Schwab, Justin, Mandaroux, Bastien, Kayda, Edwin
• Primary Examiner(s): Price, Nathan R
• Assistant Examiner(s): Fredrickson, Courtney B
• Application Number:
  US14/852,903
• Publication Number:
  US 20160095984A1
• Time in Patent Office: 1,275 Days
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/204 connected to external reservoirs for multiple refilling
• CPC Class Codes: A61M 5/31581 performed by rotationally moving or pivoting actuator operated by user, e.g. an injection lever or handle
• CPC Class Codes: A61M 5/31593 Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
• CPC Class Codes: A61M 5/321 Means for protection against accidental injuries by used needles
• CPC Class Codes: A61M 5/326 Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
• CPC Class Codes: A61M 5/3287 Accessories for bringing the needle into the body; Automatic needle insertion A61M5/20, A61M5/31525 take precedence
• CPC Class Codes: A61M 5/3298 Needles arranged in parallel

Abstract

Injection devices are provided which include a handpiece capable of housing a cartridge containing an injectable composition, and a head coupled to the handpiece and housing a plurality of retractable needles and a dosing mechanism. Methods of treating skin surfaces are also provided.

Claims

1. A method for treating skin comprising:

placing a distal end portion of a handheld device into direct contact with skin to be treated, the device including an elongate housing having a dosing cartridge disposed therein, a trigger extending along a longitudinal axis of the housing, a plurality of dosing chambers, and a plurality of needles in fluid communication with the plurality of dosing chambers and positioned adjacent to a distal end portion of the housing;

radially compressing the trigger to cause the device to move the plurality of needles from a retracted position to an extended position in which the plurality of needles extend longitudinally beyond the distal end portion of the housing to penetrate the skin;

applying continued radial compression to the trigger to cause distal advancement of a plunger relative to the dosing cartridge disposed within the housing to cause a dose of composition contained in each of the plurality of dosing chambers to be delivered into a portion of the skin through the plurality of needles, substantially simultaneously, while in the extended position;

releasing the trigger to permit the plurality of needles to move to the retracted position;

after the step of releasing the trigger, moving the distal end portion of the device onto another portion of the skin while maintaining the direct contact with the skin; and

after the step of moving, radially compressing the trigger to move the plurality of needles to the extended position to penetrate the skin and cause the device to deliver another dose of the composition into the another portion of the skin.

2. The method of claim 1 wherein the plurality of needles are in a retracted position during the moving.

3. The method of claim 1 wherein the dose is between 10 μ

l to about 2 ml.

4. The method of claim 3 wherein the dose is between 20 μ

l about 1 ml.

5. The method of claim 4 wherein the dose is 40 μ

l.

6. The method of claim 1 wherein the dose delivered is between 5 μ

l and 50 μ

l per needle.

7. The method of claim 1 wherein the dose delivered is 10 μ

l per needle.

8. The method of claim 1 wherein the doses are delivered to portions of skin spaced apart by a distance in the range of 5 mm and 20 mm.

9. The method of claim 1 wherein the doses are delivered to portions of skin spaced apart by 10 mm.

10. The method of claim 1 wherein the doses are delivered to portions of skin spaced apart by 15 mm.

11. A method of treating skin comprising:

positioning a distal end portion of an injection device against skin, wherein the device comprises a housing including an interior space for containing a cartridge, a trigger coupled to the housing, a head in communication with the interior space and including a plurality of dosing chambers, a plurality of retractable needles coupled to the dosing chambers;

compressing the trigger to cause (i) the plurality of retractable needles to be moved from a retracted position to an extended position in which the plurality of retractable needles extend distally beyond the distal end portion and (ii) distal advancement of a plunger relative to the cartridge to cause a dose of fluid contained in each of the plurality of dosing chambers to be ejected from the plurality of retractable needles when the plurality of retractable needles are in the extended position; and

releasing the trigger to permit (i) retraction of the plurality of retractable needles after the dosing and (ii) refilling of each dosing chamber.

12. The method of claim 11 wherein the compressing further comprises causing the device to deliver the dose of fluid into a portion of the skin through the plurality of retractable needles, substantially simultaneously.

13. The method of claim 11 further comprising, after the releasing, manually sliding the distal end portion of the device onto another portion of the skin while maintaining direct contact with the skin and after the sliding, causing the device to deliver another dose of fluid into the another portion of the skin.

14. The method of claim 13 wherein the plurality of retractable needles are in a retracted position during said sliding of the distal end portion of the device.

15. The method of claim 13 wherein the doses are delivered to portions of skin spaced apart by a distance in the range of 5 mm and 20 mm.

16. The method of claim 13 wherein the doses are delivered to portions of skin spaced apart by 10 mm.

17. The method of claim 13 wherein the doses are delivered to portions of skin spaced apart by 15 mm.

18. The method of claim 11 wherein the dose is between 10 μ

l to 2 ml.

19. The method of claim 11 wherein the dose is between 20 μ

l and 1 ml.

20. The method of claim 11 wherein the dose is 40 μ

l.

21. The method of claim 11 wherein the dose delivered is between 5 μ

l and 50 μ

l per needle.

22. The method of claim 11 wherein the dose delivered is 10 μ

l per needle.