Composite sensor assemblies for single use bioreactors
First Claim
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1. A composite sensor assembly for use with a polymeric bioprocess vessel, said composite sensor assembly comprising:
- i) a port comprising a high surface tension thermoplastic having a hollow tubular portion and a base plate portion, at least said base plate comprising a polymer fusibly sealable to the polymeric bioprocess vessel at a hole in the wall thereof; and
ii) a polymeric monitoring sensor unit including electrical and/or optical measurement components, said sensor unit fitting inside the bore of the hollow tubular portion of said port, and being adhesively retained therein by an adhesive between interfacing surfaces of said port and said sensor unit,said port providing the monitoring sensor unit components with access to contents of said polymeric bioreactor vessel, which components include means for providing incoming optical and/or electrical signals and means for collecting and transmitting measurement signals emitted by the monitoring sensor unit components.
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Abstract
A composite sensor assembly for monitoring bio-processes which is suitable for use with a polymeric bioprocess vessel or with downstream equipment, and comprises:
- i) a port comprising a high surface tension thermoplastic having a hollow tubular portion and a base plate portion, the base plate being fusibly sealable to the bioreactor vessel at a hole in the wall thereof;
- ii) a generally opaque polymeric monitoring sensor assembly including electrical, and/or optical measurement components. The sensor assembly fits inside the bore of the hollow tubular portion of the port, and is adhesively retained therein.
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Citations
26 Claims
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1. A composite sensor assembly for use with a polymeric bioprocess vessel, said composite sensor assembly comprising:
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i) a port comprising a high surface tension thermoplastic having a hollow tubular portion and a base plate portion, at least said base plate comprising a polymer fusibly sealable to the polymeric bioprocess vessel at a hole in the wall thereof; and ii) a polymeric monitoring sensor unit including electrical and/or optical measurement components, said sensor unit fitting inside the bore of the hollow tubular portion of said port, and being adhesively retained therein by an adhesive between interfacing surfaces of said port and said sensor unit, said port providing the monitoring sensor unit components with access to contents of said polymeric bioreactor vessel, which components include means for providing incoming optical and/or electrical signals and means for collecting and transmitting measurement signals emitted by the monitoring sensor unit components. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 25)
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22. A composite sensor assembly for use with a polymeric bioprocess vessel, said composite sensor assembly comprising:
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i) a port comprising a high surface tension thermoplastic having a hollow tubular portion and a base plate portion, at least said base plate comprising a polymer fusibly sealable to the polymeric bioprocess vessel at a hole in the wall thereof; and ii) a polymeric monitoring sensor unit including electrical and/or optical measurement components, said sensor unit fitting inside the bore of the hollow tubular portion of said port, and being adhesively retained therein by an adhesive between interfacing surfaces of said port and said sensor unit, said port providing the monitoring sensor unit components with access to contents of said polymeric bioreactor vessel, which components include means for providing incoming optical and/or electrical signals and means for collecting and transmitting measurement signals emitted by the components, and wherein a fluorescent dye is provided as a spot on the sensor unit and has a diameter of at least 1 mm. - View Dependent Claims (23)
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24. A composite sensor assembly for use with a polymeric bioprocess vessel, said composite sensor assembly comprising:
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i) a port comprising a high surface tension thermoplastic having a hollow tubular portion and a base plate portion, at least said base plate comprising a polymer fusibly sealable to the polymeric bioprocess vessel at a hole in the wall thereof; and ii) a polymeric monitoring sensor unit including electrical and/or optical measurement components, said sensor unit fitting inside the bore of the hollow tubular portion of said port, and being adhesively retained therein by an adhesive between interfacing surfaces of said port and said sensor unit, said port providing the monitoring sensor unit components with access to contents of said polymeric bioreactor vessel, which components include means for providing incoming optical and/or electrical signals and means for collecting and transmitting measurement signals emitted by the components, and wherein said sensor unit comprises a polymer selected from the group consisting of polycarbonates, co-polyesters, cyclo-olefin copolymers, and polystyrene.
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26. A composite sensor assembly for use with a polymeric bioprocess vessel, said composite sensor assembly comprising:
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i) a port comprising a high surface tension thermoplastic having a hollow tubular portion and a base plate portion, at least said base plate comprising a polymer fusibly sealable to the polymeric bioprocess vessel at a hole in the wall thereof; and ii) a polymeric monitoring sensor unit including electrical and/or optical measurement components, said sensor unit fitting inside the bore of the hollow tubular portion of said port, and being adhesively retained therein by a platinum-cured silicone adhesive between interfacing surfaces of said port and said sensor unit, and comprising a polymer different from the high surface tension thermoplastic, and wherein said port and said polymeric monitoring sensor unit have been sterilized by beta or gamma radiation, said port providing the monitoring sensor unit components with access to contents of said polymeric bioreactor vessel, which components include means for providing incoming optical and/or electrical signals and means for collecting and transmitting measurement signals emitted by the components.
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Specification