Laser-based Fourier ptychographic imaging systems and methods
First Claim
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1. A laser-based Fourier ptychographic imaging system, comprising:
- an angle direction device configured to direct laser light from a laser light source to a specimen surface at a sequence of illumination angles;
an optical system comprising a collection element and a focusing element, the collection element configured to receive light issuing from a specimen when it is located on the specimen surface, wherein the sequence of illumination angles and a numerical aperture of the collection element correspond to overlapping regions in a Fourier domain; and
a light detector configured to receive light focused by the focusing element from the optical system and acquire a plurality of intensity images of the specimen when it is located on the specimen surface and illuminated, each intensity image corresponding to a different illumination angle of the sequence of illumination angles.
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Abstract
Certain embodiments pertain to laser-based Fourier ptychographic (LFP) imaging systems, angle direction devices used in the LFP imaging systems, optical switches used in the LFP imaging systems, and LFP imaging methods. The LFP systems include an angle direction device for directing laser light to a sample plane at a plurality of illumination angles at different sample times. The LFP systems also include an optical system and a light detector. The optical system receives light issuing from the sample being imaged and propagates and focuses the light to the light detector acquiring raw intensity images.
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Citations
22 Claims
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1. A laser-based Fourier ptychographic imaging system, comprising:
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an angle direction device configured to direct laser light from a laser light source to a specimen surface at a sequence of illumination angles; an optical system comprising a collection element and a focusing element, the collection element configured to receive light issuing from a specimen when it is located on the specimen surface, wherein the sequence of illumination angles and a numerical aperture of the collection element correspond to overlapping regions in a Fourier domain; and a light detector configured to receive light focused by the focusing element from the optical system and acquire a plurality of intensity images of the specimen when it is located on the specimen surface and illuminated, each intensity image corresponding to a different illumination angle of the sequence of illumination angles. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A laser angle direction device for directing laser light sequentially through a plurality of different illumination angles, the laser angle direction device comprising:
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a surface; and a plurality of mirrors coupled to the surface, each mirror oriented to receive laser light from a laser light source and reflect the laser light to one of the plurality of illumination angles to a specimen surface, wherein the laser angle direction device is configured to provide the laser light from the light source sequentially to each one of the plurality of mirrors at a different sampling time during operation. - View Dependent Claims (17, 18, 19, 20, 22)
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21. A laser-based Fourier ptychographic imaging method employing a laser light source, the method comprising:
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directing laser light from the laser light source to a specimen surface located at about a sample plane using an angle direction device at a sequence of illumination angles; receiving light, at a light detector, issuing from a sample when the sample is located on the specimen surface, the light received from an optical system; acquiring a plurality of intensity images based on light received at the light detector, wherein each intensity image corresponds to one of the illumination angles; and constructing a higher resolution image by simultaneously updating a pupil function and a sample spectrum, wherein the sample spectrum is updated in overlapping regions with Fourier transformed intensity images, wherein each of the overlapping regions corresponds to one of the plurality of illumination angles.
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Specification