Systems and methods for measuring oxygenation

• US 10,231,656 B2
• Filed: 07/08/2015
• Issued: 03/19/2019
• Est. Priority Date: 04/11/2007
• Status: Active Grant

• Current Assignee: Noninvasix, Inc., Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Noninvasix, Inc., Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Esenaliev, Rinat, Prough, Donald S., Petrov, Yuriy, Petrov, Irene, Saade, George, Olson, Gayle L., Cooper, Tommy G.
• Primary Examiner(s): Winakur, Eric
• Assistant Examiner(s): Farndanesh, Marjan
• Application Number:
  US14/794,037
• Publication Number:
  US 20160015304A1
• Time in Patent Office: 1,350 Days
• Field of Search: None
• CPC Class Codes: A61B 2562/0271 Thermal or temperature sensors
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14553 specially adapted for cerebral tissue
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/1464 specially adapted for foetal tissue
• CPC Class Codes: A61B 5/6814 Head
• CPC Class Codes: A61B 5/6875 Uterus
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence

Abstract

Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.

Claims

1. A desktop-sized console for monitoring oxygenation of a subject, said console comprising:

a laser diode subsystem for emitting light pulses directed to tissue of a subject, the laser diode subsystem comprising;

a first laser diode configured to emit a first light pulse at a first output wavelength,

a first thermoelectric cooler coupled to the first laser diode to regulate a temperature of the first laser diode,

a second laser diode configured to emit a second light pulse at a second output wavelength different from the first output wavelength,

a second thermoelectric cooler coupled to the second laser diode to regulate a temperature of the second laser diode,

a first cooling fan, and

at least one controller coupled to and configured to control the first cooling fan, the first thermoelectric cooler, and the second thermoelectric cooler to regulate the temperatures of the first and second laser diodes to stabilize the output wavelengths of the first and second laser diodes within optimal ranges;

an acoustic sensor subsystem for measuring acoustic pressure generated in the tissue in response to the emitted light pulses; and

a processor coupled to the laser diode subsystem to control the laser diode subsystem and coupled to the acoustic sensor subsystem to receive the measured acoustic pressure, wherein the processor is configured to determine oxygenation of the subject in response to the received acoustic pressure.

2. The console of claim 1, wherein the laser diode subsystem further comprises a third laser diode configured to emit a third light pulse at a third output wavelength different from the first and second output wavelengths and a third thermoelectric cooler coupled to the third laser diode to regulate a temperature of the third laser diode, and wherein the at least one controller is further coupled to the third thermoelectric cooler to regulate the temperature of the third laser diode and to stabilize the output wavelength of the third laser diode within an optimal range.

3. The console of claim 2, wherein the laser diode subsystem further comprises a first temperature sensor to measure the temperature of the first laser diode, a second temperature sensor to measure the temperature of the second laser diode, and a third temperature sensor to measure the temperature of the third laser diode, and wherein the at least one controller is configured to regulate the temperatures of the first, second, and third laser diodes in response to the temperatures measured by the first, second, and third temperature sensors.

4. The console of claim 1, wherein the first, second, or third wavelength is in a range of 685 nm to 715 nm, 715 nm to 745 nm, 745 nm to 775 nm, 790 nm to 820 nm, or 845 nm to 875 nm.

5. The console of claim 1, wherein the laser diode subsystem further comprises a first temperature sensor to measure the temperature of the first laser diode and a second temperature sensor to measure the temperature of the third laser diode, and wherein the controller is configured to regulate the temperatures of the first and second laser diodes in response to the temperatures measured by the first and second temperature sensors.

6. The console of claim 5, wherein the first or second wavelength is in a range of 685 nm to 715 nm, 715 nm to 745 nm, 745 nm to 775 nm, 790 nm to 820 nm, or 845 nm to 875 nm.

7. The console of claim 1, further comprising a power supply coupled to the laser diode subsystem, the acoustic sensor subsystem, and the processor.

8. The console of claim 1, further comprising a display coupled to the processor to display the determined oxygenation to a user.

9. The console of claim 8, wherein the display comprises a touch screen for operating the console.

10. The console of claim 1, further comprising a desktop-sized housing enclosing the laser diode subsystem, the acoustic sensor subsystem, and the processor.

11. The console of claim 10, further comprising a second cooling fan coupled to one or more of the processor or acoustic sensor subsystem for cooling the console.

12. The console of claim 1, wherein the processor is further configured to read or write to medical records of the subject.

13. The console of claim 1, further comprising an output port for the laser diode subsystem and an input port for the acoustic sensor subsystem.

14. The console of claim 13, wherein the output port and the input port are configured to be coupled to a sensor module or an optoacoustic probe to emit the one or more of the first or second light pulses to the tissue of the subject and to receive the acoustic pressure generated in the tissue.

15. The console of claim 14, wherein the output port and the input port are configured to be coupled to the sensor module or optoacoustic probe with a cable comprising one or more optical fibers.

16. A method of monitoring oxygenation of a subject, said method comprising:

generating, with a first laser diode, a first light pulse at a first output wavelength;

generating, with a second laser diode, a second light pulse at a second output wavelength different from the first output wavelength;

regulating temperatures of the first and second laser diodes to stabilize the output wavelengths of the first and second laser diodes within optimal ranges, wherein the temperatures are regulated with a first thermoelectric cooler coupled to the first laser diode, a second thermoelectric cooler coupled to the second laser diode, and a first cooling fan;

directing the generated first and second light pulses to tissue of a subject;

measuring acoustic pressure generated in the tissue in response to the directed first and second light pulses; and

determining oxygenation of the subject in response to the measured acoustic pressure.

17. The method of claim 16, further comprising:

generating, with a third laser diode, a third light pulse having a third output wavelength different from the first and second output wavelengths;

regulating a temperature of the third laser diode to stabilize the output wavelengths of the first and second laser diodes within optimal ranges, wherein the temperatures are regulated with a third thermoelectric cooler coupled to the third laser diode and the first cooling fan; and

directing the generated third light pulse to the tissue of the subject,

wherein the measured acoustic pressure is generated in the tissue in response to the directed first, second, and third light pulses.

18. The method of claim 17, further comprising measuring the temperature of the first laser diode, measuring the temperature of the second laser diode, measuring the temperature of the third laser diode, and regulating the temperatures of the first, second, and third laser diodes in response to the temperatures measured.

19. The method of claim 17, wherein the first, second, or third wavelength is in a range of 685 nm to 715 nm, 715 nm to 745 nm, 745 nm to 775 nm, 790 nm to 820 nm, or 845 nm to 875 nm.

20. The method of claim 16, further comprising measuring the temperature of the first laser diode and the temperature of the second laser diode, and regulating the temperatures of the first and second laser diodes are regulated in response to the temperatures measured.

21. The method of claim 16, wherein the first or second wavelength is in a range of 685 nm to 715 nm, 715 nm to 745 nm, 745 nm to 775 nm, 790 nm to 820 nm, or 845 nm to 875 nm.

22. The method of claim 16, further comprising displaying the determined oxygenation of the subject.

23. The method of claim 16, further comprising regulating temperatures of the first and second laser diodes with a second cooling fan.

24. The method of claim 23, wherein the second cooling fan is enclosed within a housing enclosing the first laser diode, the second laser diode, and the first cooling fan.

25. The method of claim 16, wherein directing the generated first and second light pulses to tissue of the subject comprises directing the first and second light pulses with an optical waveguide of a sensor module or an optoacoustic sensor coupled to the first and second photodiodes.

26. The method of claim 25, wherein the acoustic pressure is measured by an acoustic transducer of the sensor module or the optoacoustic sensor.