Methods for treating depressive symptoms
First Claim
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1. A method of treating a depressive symptom in a subject in need thereof, the method comprising administering to the subject an effective amount of a p opioid receptor agonist that exhibits an Emax of 5% to 45% in a GTPγ
- S binding assay wherein the depressive symptom is depressed mood, loss of pleasure, loss of appetite, sleep disturbance, psychomotor changes, fatigue, and/or post-partum depression.
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Abstract
The present application relates methods for treating a depressive symptom comprising administering an effective amount of a μ opioid receptor agonist or a pharmaceutically acceptable salt thereof to a subject in need thereof. Non-limiting examples of such agonist include the compounds of Formulas I, II, III, and IV, as well as the compounds of Table A.
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Citations
9 Claims
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1. A method of treating a depressive symptom in a subject in need thereof, the method comprising administering to the subject an effective amount of a p opioid receptor agonist that exhibits an Emax of 5% to 45% in a GTPγ
- S binding assay wherein the depressive symptom is depressed mood, loss of pleasure, loss of appetite, sleep disturbance, psychomotor changes, fatigue, and/or post-partum depression.
- View Dependent Claims (4, 5)
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2. A method of treating a depressive symptom in a subject in need thereof, the method comprising administering to the subject an effective amount of a μ
- opioid receptor agonist that exhibits an Emax of 5% to 45% in a GTPγ
S binding assay wherein the depressive symptom is acute stress disorder, adjustment disorders with depressed mood, Asperger syndrome, attention deficit, bereavement, bipolar I disorder, bipolar II disorder, borderline and personality disorder, cyclothymia and dysthymia, depression such as major depressive disorder (MDD) and treatment-resistant disorder (TRD), Dysthymic disorder, hyperactivity disorder, impulse control disorder, mixed mania, obsessive-compulsive personality disorder (OCD), paranoid, post-traumatic stress disorder, seasonal affective disorder, self-injury separation, sleep disorder, substance-induced mood disorder, Tourette syndrome and tic disorder, and/or Trichotillomania. - View Dependent Claims (6, 7)
- opioid receptor agonist that exhibits an Emax of 5% to 45% in a GTPγ
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3. A method of treating a depressive symptom in a subject in need thereof, the method comprising administering to the subject an effective amount of a μ
- opioid receptor agonist that exhibits an Emax of 5% to 45% in a GTPγ
S binding assay wherein the depressive symptom is an anxiety disorder, wherein the anxiety disorder is generalized anxiety disorder, panic, agoraphobia, acute stress, and/or post-traumatic stress disorder. - View Dependent Claims (8, 9)
- opioid receptor agonist that exhibits an Emax of 5% to 45% in a GTPγ
Specification