Stents and other devices having extracellular matrix coating
First Claim
Patent Images
1. A device comprisinga substrate;
- anda coating on said substrate comprising a first polymer and an active agent, wherein the active agent comprises a macrolide immunosuppressive drug in crystalline form and an extracellular matrix, wherein the extracellular matrix comprises an interlocking mesh of fibrous proteins and glycosaminoglycans (GAGs).
5 Assignments
0 Petitions
Accused Products
Abstract
Provided herein are devices comprising a stent; and a coating on said stent comprising a polymer and an active agent, wherein the active agent comprises at least one of: extracellular matrix and an extracellular matrix component. Provided herein are methods of preparing a device comprising a stent and a coating on said stent; said method comprising: providing a stent; and forming a plurality of layers on said stent; wherein the coating comprises a polymer and at least one of said layers comprises one or more active agents; wherein at least a portion of the active agent comprises at least one of extracellular matrix and an extracellular matrix component.
-
Citations
15 Claims
-
1. A device comprising
a substrate; - and
a coating on said substrate comprising a first polymer and an active agent, wherein the active agent comprises a macrolide immunosuppressive drug in crystalline form and an extracellular matrix, wherein the extracellular matrix comprises an interlocking mesh of fibrous proteins and glycosaminoglycans (GAGs). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- and
-
10. A stent delivery system comprising:
-
an elongate member having an inflation lumen and a guidewire lumen therein; a balloon having an interior that is in fluid communication with the inflation lumen; and a coated stent mounted on the balloon, wherein the coated stent comprises a stent and a plurality of layers that form a coating on said stent; wherein at least one of said layers comprises a polymer and at least one of said layers comprises an active agent, wherein the active agent comprises a macrolide immunosuppressive drug in crystalline form and an extracellular matrix, wherein the extracellular matrix comprises an interlocking mesh of fibrous proteins and glycosaminoglycans (GAGs).
-
-
11. A bioabsorbable device comprising
a bioabsorbable substrate comprising a first active agent; - and
a coating on said substrate wherein the coating comprises a first polymer, wherein the first active agent comprises a macrolide immunosuppressive drug in crystalline form and an extracellular matrix, wherein the extracellular matrix comprises an interlocking mesh of fibrous proteins and glycosaminoglycans (GAGs). - View Dependent Claims (13, 14, 15)
- and
-
12. A bioabsorbable device comprising
a bioabsorbable substrate; - and
a coating on said substrate wherein the coating comprises a first polymer, a first active agent and a second active agent, wherein the first active agent comprises extracellular matrix, the extracellular matrix comprises an interlocking mesh of fibrous proteins and glycosaminoglycans (GAGs), and the second active agent comprises a macrolide immunosuppressive drug in crystalline form.
- and
Specification