System, method, and composition for removing uremic toxins in dialysis processes
First Claim
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1. A dialysis system comprising:
- a disposable pumping cassette;
a dialyzer;
a patient loop;
a patient loop pump for pumping a patient fluid through the patient loop and the dialyzer;
a regeneration loop;
a dialysate supply container;
a dialysate pump positioned and arranged to fluidly communicate dialysate from the dialysate supply container to the regeneration loop;
a supply of concentrate;
a concentrate pump for pumping concentrate from the supply of concentrate to the regeneration loop; and
a sorbent cartridge for cleaning used dialysate flowing in the regeneration loop, wherein the sorbent cartridge includes (i) a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, and (ii) a concentrate port for receiving concentrate from the supply of concentrate.
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Abstract
Methods and devices for providing dialysis treatment are provided. The device comprises a cartridge for providing regenerative dialysis, the cartridge comprising: a body having an inlet and an outlet and defining an interior, the interior including at least a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, wherein at least two of the layers are blended together to provide a gradient of the two materials.
348 Citations
25 Claims
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1. A dialysis system comprising:
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a disposable pumping cassette; a dialyzer; a patient loop; a patient loop pump for pumping a patient fluid through the patient loop and the dialyzer; a regeneration loop; a dialysate supply container; a dialysate pump positioned and arranged to fluidly communicate dialysate from the dialysate supply container to the regeneration loop; a supply of concentrate; a concentrate pump for pumping concentrate from the supply of concentrate to the regeneration loop; and a sorbent cartridge for cleaning used dialysate flowing in the regeneration loop, wherein the sorbent cartridge includes (i) a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, and (ii) a concentrate port for receiving concentrate from the supply of concentrate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A dialysis system comprising:
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a disposable pumping cassette; a dialyzer; a patient loop; a patient loop pump for pumping a patient fluid through the patient loop and the dialyzer; a regeneration loop; a sorbent cartridge for cleaning used dialysate flowing in the regeneration loop, wherein the sorbent cartridge includes a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon; a gas vent located downstream from a resin bed of the sorbent cartridge for venting gas from the regeneration loop; a dialysate supply container; a dialysate pump positioned and arranged to fluidly communicate dialysate from the dialysate supply container to the regeneration loop; a supply of concentrate; and a concentrate pump in fluid communication with the supply of concentrate for supplying concentrate to the regeneration loop. - View Dependent Claims (18, 19, 20, 21, 22, 23)
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24. A dialysis system comprising:
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a disposable pumping cassette; a dialyzer; a patient loop; a patient loop pump for pumping a patient fluid through the patient loop and the dialyzer; a regeneration loop; a sorbent cartridge for cleaning used dialysate flowing in the regeneration loop, wherein the sorbent cartridge includes a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, the sorbent cartridge further including a gas separation chamber having a gas vent for venting gas from the gas separation chamber; a dialysate supply container; a dialysate pump positioned and arranged to fluidly communicate dialysate from the dialysate supply container to the regeneration loop; a supply of concentrate; and a concentrate pump for pumping concentrate from the supply of concentrate to the regeneration loop.
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25. A dialysis system comprising:
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a disposable pumping cassette; a dialyzer; a patient loop; a patient loop pump for pumping a patient fluid through the patient loop and the dialyzer; a regeneration loop; a dialysate supply container; a dialysate pump positioned and arranged to fluidly communicate dialysate from the dialysate supply container to the regeneration loop; a supply of concentrate; a concentrate pump for pumping concentrate from the supply of concentrate to the regeneration loop; and a sorbent cartridge for cleaning used dialysate flowing in the regeneration loop, wherein the sorbent cartridge includes a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, the sorbent cartridge further including an outlet cap, the outlet cap including (i) a dialysate fluid outlet, and (ii) a gas vent for venting gas from the gas separation chamber, and (iii) a concentrate port for receiving concentrate from the supply of concentrate.
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Specification