Transdermal drug delivery apparatus and methods

• US 10,232,160 B2
• Filed: 04/29/2015
• Issued: 03/19/2019
• Est. Priority Date: 04/30/2014
• Status: Active Grant

• Current Assignee: CTP Biotechnology, LLC, Kimberly-Clark Worldwide Incorporated (Kimberly-Clark Corporation), Sorrento Therapeutics Inc.
• Original Assignee: Sorrento Therapeutics Inc.
• Inventors: Baker, Andrew T., Gadsby, Elizabeth Deibler, Ross, Russell F., Hagan, Luke
• Primary Examiner(s): Eisenberg, Rebecca E
• Application Number:
  US15/305,193
• Publication Number:
  US 20170120025A1
• Time in Patent Office: 1,420 Days
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 37/0015 by using microneedles

Abstract

A transdermal drug delivery apparatus includes a housing for being fastened to a user, a microneedle assembly for being engaged against the skin of the user, a first force provider for providing a first force for forcing the microneedle assembly outwardly from the housing and against the skin, a reservoir movably carried by the housing for containing the fluid and for being in fluid communication with the microneedle assembly, and a second force provider for providing a second force for causing at least some of the fluid to flow from the reservoir to the microneedle assembly after the reservoir has moved into fluid communication with the microneedle assembly.

Claims

1. A transdermal drug delivery apparatus configured to be engaged to skin of a user and supply fluid, the transdermal drug delivery apparatus comprising:

a housing configured to be fastened to the user;

a microneedle assembly configured to be engaged against the skin, wherein the microneedle assembly is movably mounted to the housing to allow relative movement between the microneedle assembly and the housing;

a first force provider configured to provide a first force to force the microneedle assembly outwardly from the housing and against the skin;

a reservoir carried by the housing configured to contain the fluid and be in fluid communication with the microneedle assembly; and

a second force provider configured to provide a second force to cause at least some of the fluid to flow from the reservoir to the microneedle assembly.

2. The apparatus according to claim 1, wherein the reservoir being carried by the housing is comprised of the reservoir being movably mounted to the housing by way of at least one snap-fit connector.

3. The apparatus according to claim 1, wherein:

the apparatus further comprises a latching mechanism adapted to be transitioned between

a latched state configured to restrict expansion of the second force provider, and

an unlatched state configured to allow expansion of the second force provider; and

the microneedle assembly being movably mounted to the housing to allow relative movement between the microneedle assembly and the housing is comprised of there being at least one deformable component connected between the microneedle assembly and the housing configured to both allow and restrict expansion of the first force provider independently of operation of the latching mechanism.

4. The apparatus according to claim 1, wherein the first and second force providers are respectively configured so that the first force is greater than the second force.

5. The apparatus according to claim 1, wherein:

the first force provider comprises a spring; and

the second force provider comprises a spring.

6. The apparatus according to claim 5, wherein the first spring is larger than the second spring.

7. The apparatus according to claim 1, wherein the second force provider is operatively associated with the reservoir to facilitate at least partially collapsing the reservoir.

8. The apparatus according to claim 1, further comprising an adhesive fastener configured to fasten the housing to the skin of the user.

9. The apparatus according to claim 1, wherein the reservoir is mounted to the housing and configured to be moved relative to the housing from a first position in which the reservoir is out of fluid communication with the microneedle assembly to a second position in which the reservoir is in fluid communication with the microneedle assembly.

10. The apparatus according to claim 9, further comprising a pushbutton movably mounted to the housing and configured to be pushed to move the reservoir from the first position to the second position.

11. The apparatus according to claim 10, further comprising a latching mechanism configured to open in response to the pushbutton being pushed, wherein the second force provider is configured to provide the second force in response to the latching mechanism being opened.

12. A transdermal drug delivery apparatus comprising:

a receptacle comprising a housing and a microneedle assembly mounted to the housing;

a pushbutton movably mounted to the housing and configured to be pushed towards the microneedle assembly;

a reservoir configured to contain fluid to be supplied to the microneedle assembly, wherein

the reservoir is configured to move with the pushbutton relative to the housing along a path from an outer position to an inner position,

in the outer position the reservoir is out of fluid communication with the microneedle assembly, and

in the inner position the reservoir is in fluid communication with the microneedle assembly;

a latching mechanism configured to open in response to the pushbutton being pushed towards the microneedle assembly;

a pushing mechanism configured to release in response to the latching mechanism being opened; and

a deformable membrane positioned between at least a portion of the pushing mechanism and the reservoir, wherein the pushing mechanism engages the deformable membrane to at least partially collapse the reservoir while the reservoir is in fluid communication with the microneedle assembly.

13. The apparatus according to claim 12, wherein the pushing mechanism comprises a plunger.

14. The apparatus according to claim 12, wherein:

the housing is configured to be fastened to a user; and

the microneedle assembly is movably mounted to the housing by at least one spring configured to force the microneedle assembly against skin of the user.

15. The apparatus according to claim 12, comprising at least one spring configured to force the pushing mechanism against the reservoir in response to the latching mechanism being opened.

16. The apparatus according to claim 12, wherein:

the housing is configured to be fastened to a user;

the microneedle assembly is movably mounted to the housing by at least a first force provider configured to force the microneedle assembly against skin of the user; and

the pushing mechanism is movably mounted to the pushbutton by at least a second force provider configured to force the pushing mechanism against the reservoir in response to the latching mechanism being opened.

17. A transdermal drug delivery apparatus configured to be engaged to skin of a user and supply fluid, the transdermal drug delivery apparatus comprising:

a housing configured to be fastened to the user;

a microneedle assembly mounted to the housing and configured to allow relative movement between the microneedle assembly and the housing, comprising a first force provider positioned between the housing and the microneedle assembly configured to urge the microneedle assembly outwardly relative to the housing and against the skin;

a reservoir mounted to the housing and configured to be moved relative to the housing from a first position in which the reservoir is out of fluid communication with the microneedle assembly to a second position in which the reservoir is in fluid communication with the microneedle assembly; and

a second force provider configured to at least partially collapse the reservoir while the reservoir is in fluid communication with the microneedle assembly.

18. The apparatus according to claim 17, comprising a fastener configured to fasten the housing to the user.

19. The apparatus according to claim 17, wherein:

the first force provider comprises a first spring positioned between the housing and the microneedle assembly configured to urge the microneedle assembly outwardly relative to the housing;

the second force provider is part of a controller that further comprises a pushing mechanism; and

the second force provider comprises a second spring configured to urge the pushing mechanism against the reservoir.

20. The apparatus according to claim 19, wherein the controller further comprises a pushbutton that is connected to the reservoir configured to move with the reservoir relative to the housing of the apparatus.

21. The apparatus according to claim 17, wherein the microneedle assembly being mounted to the housing and configured to allow relative movement between the microneedle assembly and the housing is further comprised of there being at least one deformable component connected between the microneedle assembly and the housing.

22. The apparatus according to claim 21, wherein the at least one deformable component comprises a membrane configured to restrict the first force provider from separating the microneedle assembly from the housing.

23. The apparatus according to claim 17, comprising a plurality of connector parts configured for releasably securing the reservoir in the first position.

24. The apparatus according to claim 23, wherein the plurality of connector parts are configured for securing the reservoir in the second position.

25. The apparatus according to claim 23, wherein the plurality of connector parts comprises snap-fit connector parts.

26. The apparatus according to claim 17, wherein the apparatus further comprises a pushing mechanism configured to move the reservoir relative to the housing between the first position and the second position.

27. The apparatus according to claim 26, wherein the pushing mechanism comprises a pushbutton.

28. The apparatus according to claim 26, wherein an outer portion of the pushing mechanism extends through an opening defined in the housing.

29. The apparatus according to claim 26, wherein:

the pushing mechanism is an outer pushing mechanism;

the second force provider is part of a controller that further comprises an inner pushing mechanism;

the inner pushing mechanism is mounted to the outer pushing mechanism configured to be moved relative to the outer pushing mechanism; and

the second force provided is operatively associated with the inner pushing mechanism and configured to move the inner pushing mechanism relative to both the outer pushing mechanism and the reservoir to at least partially collapse the reservoir.

30. The apparatus according to claim 29, wherein the apparatus further comprises a latching mechanism configured to release the inner pushing mechanism in response to predetermined relative movement between the outer pushing mechanism and the housing.