Selective stimulation to modulate the sympathetic nervous system
First Claim
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1. A method of treating a condition or disorder in a patient necessitating weight control, comprising:
- implanting a first stimulation lead with at least one electrode positioned to selectively stimulate a dorsal root ganglion (DRG) in the patient;
implanting a second stimulation lead with at least one electrode positioned to stimulate neural tissue of a sympathetic chain of the patient that is downstream from the DRG wherein the neural tissue of the sympathetic chain of the patient is selected from the group consisting of;
a celiac ganglion, an interior mesenteric ganglion, and a superior mesenteric ganglion; and
applying electrical stimulation, from at least one implantable pulse generator and using the first and second stimulation leads, to the DRG and to the neural tissue of the sympathetic chain to selectively modulate gastric motility and hunger in the patient and to modulate hormonal regulation to treat the condition or disorder of the patient necessitating weight control.
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Abstract
Systems, methods and devices are provided for the targeted treatment of a variety of medical conditions by directly neuromodulating a target anatomy associated with the condition while minimizing or excluding undesired neuromodulation of other anatomies. Typically, the target anatomy includes one or more dorsal root ganglia, dorsal roots, dorsal root entry zones, or portions thereof. Such target stimulation areas are utilized due in part to their effect on the sympathetic nervous system.
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Citations
17 Claims
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1. A method of treating a condition or disorder in a patient necessitating weight control, comprising:
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implanting a first stimulation lead with at least one electrode positioned to selectively stimulate a dorsal root ganglion (DRG) in the patient; implanting a second stimulation lead with at least one electrode positioned to stimulate neural tissue of a sympathetic chain of the patient that is downstream from the DRG wherein the neural tissue of the sympathetic chain of the patient is selected from the group consisting of;
a celiac ganglion, an interior mesenteric ganglion, and a superior mesenteric ganglion; andapplying electrical stimulation, from at least one implantable pulse generator and using the first and second stimulation leads, to the DRG and to the neural tissue of the sympathetic chain to selectively modulate gastric motility and hunger in the patient and to modulate hormonal regulation to treat the condition or disorder of the patient necessitating weight control. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification
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Current AssigneeTC1 LLC (Abbott Laboratories), Board of Trustees of the Leland Stanford Junior University (Stanford University)
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Original AssigneeSt Jude Medical Luxembourg Holding SMI SARL (Abbott Laboratories), Board of Trustees of the Leland Stanford Junior University (Stanford University)
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InventorsKramer, Jeffery M., Kim, Daniel H., Imran, Mir A.
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Primary Examiner(s)Stice, Paula J
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Application NumberUS15/861,592Publication NumberTime in Patent Office440 DaysField of SearchUS Class CurrentCPC Class CodesA61N 1/0551 Spinal or peripheral nerve ...A61N 1/36057 adapted for stimulating aff...A61N 1/36071 PainA61N 1/36114 Cardiac control, e.g. by va...A61N 1/36135 using physiological parameters
