Anti-adherent composition

• US 10,238,107 B2
• Filed: 04/01/2015
• Issued: 03/26/2019
• Est. Priority Date: 07/31/2014
• Status: Active Grant

• Current Assignee: Kimberly-Clark Worldwide Incorporated (Kimberly-Clark Corporation)
• Original Assignee: Kimberly-Clark Worldwide Incorporated (Kimberly-Clark Corporation)
• Inventors: Chaudhary, Vinod, Engelbrecht, Kathleen C., Koenig, David W., Bhatt, Divesh, Vanden Heuvel, Amy L., Wenzel, Scott W., Mundschau, Stacy A.
• Primary Examiner(s): Phan, Doan T
• Application Number:
  US15/329,653
• Publication Number:
  US 20170208798A1
• Time in Patent Office: 1,455 Days
• CPC Class Codes: A01N 25/02 containing liquids as carriers, diluents or solvents
• CPC Class Codes: A01N 25/08 containing solids as carriers or diluents
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 37/44 containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
• CPC Class Codes: A01N 41/08 Sulfonic acid halides; alpha-Hydroxy-sulfonic acids; Amino-sulfonic acids; Thiosulfonic acids; Derivatives thereof
• CPC Class Codes: A01N 43/36 five-membered rings
• CPC Class Codes: A01N 45/00 Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring halogenated hydrocarbons A01N29/08; condensed with heterocyclic rings A01N43/00
• CPC Class Codes: A01N 47/20 N-Aryl derivatives thereof
• CPC Class Codes: A01N 55/00 Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing organo-phosphorus compounds A01N57/00
• CPC Class Codes: A01N 65/00 Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof containing compounds of determined constitution A01N27/00 - A01N59/00
• CPC Class Codes: A01N 65/12 Asteraceae or Compositae [Aster or Sunflower family], e.g. daisy, pyrethrum, artichoke, lettuce, sunflower, wormwood or tarragon
• CPC Class Codes: A01N 65/18 Euphorbiaceae [Spurge family], e.g. ricinus [castorbean]
• CPC Class Codes: A61K 8/0208 Tissues; Wipes; Patches
• CPC Class Codes: A61K 8/8152 Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/8158 Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/86 Polyethers
• CPC Class Codes: A61K 8/891 saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
• CPC Class Codes: A61K 8/893 modified by an alkoxy or aryloxy group, e.g. behenoxy dimethicone or stearoxy dimethicone
• CPC Class Codes: A61K 8/895 containing silicon bound to unsaturated aliphatic groups, e.g. vinyl dimethicone
• CPC Class Codes: A61K 8/898 containing nitrogen, e.g. amodimethicone, trimethyl silyl amodimethicone or dimethicone propyl PG-betaine
• CPC Class Codes: A61K 8/90 : Block copolymers A61K8/89 takes precedence
• CPC Class Codes: A61K 8/922 : of vegetable origin
• CPC Class Codes: A61K 8/925 : of animal origin
• CPC Class Codes: A61K 8/97 : from algae, fungi, lichens or plants; from derivatives thereof
• CPC Class Codes: A61Q 17/005 : Antimicrobial preparations
• CPC Class Codes: C08G 2650/58 : Ethylene oxide or propylene oxide copolymers, e.g. pluronics
• CPC Class Codes: C08L 2203/02 : for biomedical use
• CPC Class Codes: C08L 2205/02 : containing two or more polymers of the same C08L -group
• CPC Class Codes: C08L 71/02 : Polyalkylene oxides

Abstract

Compositions for inhibiting the attachment of microbes to a biotic or abiotic surface are disclosed. The compositions include a carrier and an effective amount of an anti-adherent agent. The anti-adherent agents include Dimethicone Propyl PG-Betaine, PEG-150/Decyl Alcohol/SMDI Copolymer, Ammonium Acryloyl Dimethyltaurate/Carboxyethyl, Acrylate Crosspolymer, PEG-20 Soy Sterol, PEG/PPG-25/25 Dimethicone, PEG-12 Dimethicone, Dimethicone, Cyclopentasiloxane (and) PEG-12 Dimethicone Crosspolymer, PPG-12-PEG-50 Lanolin, Glycerin (and) Glycine Max (Soybean) Seed Extract, VP/Dimethiconylacrylate/Polycarbamyl/Polyglycol Ester, PEG-10 Sunflower Glycerides, PEG-8 Amodimethicone, PEG/PPG 20/23 Dimethicone Isobutylene/Ethylmaleimide/Hydroxyethylmaleimide Copolymer, Methacryloyl Ethyl Betaine/Acrylates Copolymer, Poloxamer 407, Ethylene Oxide/Propylene Oxide Block Copolymer, PEG-200 Hydrogenated Castor Oil/IPDI Copolymer, PEG-15 Soyamine/IPDI Copolymer Dimer Dilinoleate, Dimethicone PEG-7 Isostearate, PEG-12 Dimethicone, PEG-17 Dimethicone, Polyoxyethylene Polyoxypropylene block copolymer, Polyalkyleneoxide modified silicone copolymer, Disteareth-75 IPDI, and combinations thereof. Various delivery vehicles, including wipes, may be used to deliver the composition to surfaces.

Claims

1. A non-antimicrobial composition for inhibiting the attachment of microbes to a surface, the non-antimicrobial composition comprising:

a liquid carrier; and

an effective amount of an anti-adherent agent selected from the group consisting of Dimethicone Propyl PG-Betaine, PEG-150/Decyl Alcohol/SMDI Copolymer, Ammonium Acryloyl Dimethyltaurate/Carboxyethyl Acrylate Crosspolymer, PEG-20 Soy Sterol, PEG/PPG-25/25 Dimethicone, PPG-12-PEG-50 Lanolin, Glycerin (and) Glycine Max (Soybean) Seed Extract, VP/Dimethiconylacrylate/Polycarbamyl/Polyglycol Ester, PEG-10 Sunflower Glycerides, PEG-8 Amodimethicone, PEG/PPG 20/23 Dimethicone, Methacryloyl Ethyl Betaine/Acrylates Copolymer, PEG-200 Hydrogenated Castor Oil/IPDI Copolymer, PEG-15 Soyamine/IPDI Copolymer Dimer Dilinoleate, PEG-17 Dimethicone, and combinations thereof; and

wherein the anti-adherent agent is a non-antimicrobial and is present in the amount of 0.10% to 20% by weight of the composition.

2. The composition of claim 1 wherein the liquid carrier is hydrophilic.

4. The composition of claim 1 further comprising a humectant selected from the group consisting of honey, sorbitol, hyaluronic acid, sodium hyaluronate, betaine, lactic acid, citric acid, sodium citrate, glycolic acid, sodium glycolate, sodium lactate, urea, propylene glycol, butylene glycol, pentylene glycol, ethoxydiglycol, methyl gluceth-10, methyl gluceth-20, PEG-2, PEG-4, PEG-5, PEG-6, PEG-7, PEG-8, PEG-9, PEG-10, Propanediol, xylitol, maltitol, and combinations thereof.

5. The composition of claim 1 comprising an emollient.

6. The composition of claim 1 further comprising an emulsifier.

7. The composition of claim 1 wherein the anti-adherent agent reduces the attachment of microbes to a polystyrene surface by at least 0.5 Log of bacteria according to a High Throughput Anti-adherent Test or a Viable Count Anti-adherence Test Method.

8. The composition of claim 1 wherein the anti-adherent agent reduces the attachment of microbes to a polystyrene surface by at least 1 Log of bacteria according to a High Throughput Anti-adherent Test or a Viable Count Anti-adherence Test Method.

9. The composition of claim 1 further comprising a foaming agent.

3. The composition of 1 further comprising a humectant selected from the group consisting of glycerin, glycerin derivatives, hyaluronic acid derivatives, betaine derivatives amino acids, amino acid derivatives, glycosaminoglycans, glycols, polyols, sugars, sugar alcohols, hydrogenated starch hydrolysates, hydroxy acids, hydroxy acid derivatives, salts of PCA, and combinations thereof.

10. A wipe comprising:

a nonwoven substrate;

an anti-adherent agent composition comprising 0.10% to 20% by total weight of composition of an anti-adherent agent; and

a hydrophilic carrier;

wherein the composition reduces the adherence of S. aureus on a surface by at least 0.5 log according to a High Throughput Anti-adherent Test Method or a Viable Count Anti-adherence Test Method, and

wherein the anti-adherent composition is non-antimicrobial and the anti-adherent agent is selected from the group consisting of Dimethicone Propyl PG-Betaine, PEG-150/Decyl Alcohol/SMDI Copolymer, Ammonium Acryloyl Dimethyltaurate/Carboxyethyl Acrylate Crosspolymer, PEG-20 Soy Sterol, PEG/PPG-25/25 Dimethicone, PPG-12-PEG-50 Lanolin, Glycerin (and) Glycine Max (Soybean) Seed Extract, VP/Dimethiconylacrylate/Polycarbamyl/Polyglycol Ester, PEG-10 Sunflower Glycerides, PEG-8 Amodimethicone, PEG/PPG 20/23 Dimethicone, Methacryloyl Ethyl Betaine/Acrylates Copolymer, PEG-200 Hydrogenated Castor Oil/IPDI Copolymer, PEG-15 Soyamine/IPDI Copolymer Dimer Dilinoleate, PEG-17 Dimethicone, and combinations thereof.

11. The wipe of claim 10 wherein the anti-adherent agent is present in the amount of 0.1% to 10% by total weight of the composition.

12. The wipe of claim 10 wherein the anti-adherent composition further comprises one or more of ingredients selected from the group consisting of a humectant, an emollient, an emulsifier, and any combination thereof.