Gelatin/pectin particles

• US 10,238,603 B2
• Filed: 02/09/2017
• Issued: 03/26/2019
• Est. Priority Date: 09/11/2014
• Status: Active Grant

• Current Assignee: Gelita AG
• Original Assignee: Gelita AG
• Inventors: Dolphin, John M., Montgomery, Michelle A.
• Primary Examiner(s): Rosenthal, Andrew S
• Application Number:
  US15/428,793
• Publication Number:
  US 20170151176A1
• Time in Patent Office: 775 Days
• CPC Class Codes: A23L 21/00 Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
• CPC Class Codes: A23L 29/231 Pectin; Derivatives thereof
• CPC Class Codes: A23L 29/284 Gelatin; Collagen
• CPC Class Codes: A23L 29/30 containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin products from apiculture A23L21/20; artificial sweetening agents A23L27/30
• CPC Class Codes: A23P 10/20 Agglomerating; Granulating; Tabletting
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A61K 9/1623 Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
• CPC Class Codes: A61K 9/1652 Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin homeopathic globules A61K9/1623
• CPC Class Codes: A61K 9/1658 Proteins, e.g. albumin, gelatin
• CPC Class Codes: A61K 9/1694 resulting in granules or microspheres of the matrix type containing more than 5% of excipient
• CPC Class Codes: A61K 9/4816 Wall or shell material
• CPC Class Codes: A61K 9/4825 Proteins, e.g. gelatin gelatin capsule shells with substantial amounts of other macromolecular substances A61K9/4816

Abstract

Disclosed are particles comprising pectin and gelatin. The particles may be useful for preparing any of a variety products such as, for example, soft pharmaceutical capsules, hard pharmaceutical capsules, and foodstuffs. Also disclosed are methods for preparing the particles, the method comprising: (a) dissolving pectin in an aqueous solution to produce an aqueous solution of dissolved pectin; (b) mixing the aqueous solution of dissolved pectin with liquid gelatin to produce a gelatin/pectin mixture; (c) drying the gelatin/pectin mixture; and (d) milling the gelatin/pectin mixture to produce the plurality of particles.

Claims

1. A plurality of particles, which are made by a method comprising:

(a) dissolving pectin in an aqueous solution to produce an aqueous solution of dissolved pectin;

(b) mixing the aqueous solution of dissolved pectin with liquid gelatin to produce a gelatin/pectin mixture;

(c) drying the gelatin/pectin mixture; and

(d) milling the gelatin/pectin mixture to produce the plurality of particles wherein the particles consist of;

(i) water;

(ii) pectin;

(iii) gelatin;

(iv) optionally one or more carbohydrates;

(v) optionally one or more organic acids or salt(s) thereof; and

(vi) optionally one or more inorganic salts.

2. The plurality of particles of claim 1, wherein the pectin is low methoxyl (LM) pectin, high methoxyl (HM) pectin, amidated high methoxyl pectin, or amidated low methoxyl pectin.

3. The plurality of particles of claim 1, wherein the gelatin is type B gelatin.

4. The plurality of particles of claim 1, wherein the gelatin comprise is type A gelatin.

5. The plurality of particles of claim 1, wherein the gelatin has a bloom range of from 50 to 300.

6. The plurality of particles of claim 1, wherein the gelatin has a bloom range of from 70 to 180.

7. The plurality of particles of claim 1, wherein the particles have an inorganic salt of multiple charged cations content of less than 100 parts per million with respect to the particles.

8. The plurality of particles of claim 1, wherein the particles have an inorganic salt of multiple charged cations content of greater than 100 parts per million with respect to the particles.

9. The plurality of particles of claim 1, wherein the pectin is present in an amount of from 1% to 30% by weight (in relation to dry mass).

10. The plurality of particles of claim 1, wherein the pectin is present in an amount of from 5% to 15% by weight (in relation to dry mass).

11. The plurality of particles of claim 1, wherein the gelatin is present in an amount of from 70% to 99% by weight (in relation to dry mass).

12. The plurality of particles of claim 1, wherein the gelatin is present in an amount of from 85% to 95% by weight (in relation to dry mass).

13. The plurality of particles of claim 1, wherein the particles have a size of from 6 mesh to 40 mesh.

14. The plurality of particles of claim 1, wherein the particles have a size of from 6 mesh to 16 mesh.

15. The plurality of particles of claim 1, wherein the one or more carbohydrates is/are present in the particles.

16. The plurality of particles of claim 15, wherein the one or more carbohydrates is/are one or more of maltodextrin, sucrose, glucose, and maltose.

17. The plurality of particles of claim 1, wherein the particles dissolve in water at ≤

60°

C.

18. The plurality of particles of claim 1, wherein the particles dissolve in a mixture of water and at least one plasticizer at ≤

60°

C.

19. The plurality of particles of claim 18, wherein the plasticizer is glycerol, sorbitol, sorbitan, mannitol, or any combination thereof.

20. The plurality of particles of claim 18, wherein the plasticizer is present in an amount from 5% to 40% by weight of the total amount of the mixture.

21. A method of making the plurality of particles of claim 1, the method comprising:

(a) dissolving pectin in an aqueous solution to produce an aqueous solution of dissolved pectin;

(b) mixing the aqueous solution of dissolved pectin with liquid gelatin to produce a gelatin/pectin mixture;

(c) drying the gelatin/pectin mixture; and

(d) milling the gelatin/pectin mixture to produce the plurality of particles.