Controlled activation ingestible identifier
First Claim
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1. A pharmaceutical composition comprising:
- a pharmaceutically active agent;
a controlled activation identifier configured to transmit a signal upon contact with a target site of a body, wherein the controlled activation identifier comprises;
first and second materials with dissimilar electrochemical properties;
a dried conductive medium precursor; and
a plurality of protective layers comprising;
a first layer configured to prevent mechanical damage to the controlled activation identifier;
a second layer configured to dissolve at a target pH; and
a third layer configured to control exposure of the dried conductive medium precursor to the target site.
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Abstract
Controlled activation identifiers for use in ingestible compositions, such as pharma-informatics enabled compositions, are provided. The identifiers include a controlled activation element that provides for activation of the identifier in response to the presence of a predetermined stimulus at a target site of interest. The invention finds use in a variety of different applications, including but not limited to, monitoring of therapeutic regimen compliance, tracking the history of pharmaceutical agents, etc.
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Citations
17 Claims
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1. A pharmaceutical composition comprising:
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a pharmaceutically active agent; a controlled activation identifier configured to transmit a signal upon contact with a target site of a body, wherein the controlled activation identifier comprises; first and second materials with dissimilar electrochemical properties; a dried conductive medium precursor; and a plurality of protective layers comprising; a first layer configured to prevent mechanical damage to the controlled activation identifier; a second layer configured to dissolve at a target pH; and a third layer configured to control exposure of the dried conductive medium precursor to the target site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification