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Lipid nanoparticle compositions and methods for MRNA delivery

  • US 10,238,754 B2
  • Filed: 04/07/2017
  • Issued: 03/26/2019
  • Est. Priority Date: 06/08/2011
  • Status: Active Grant
First Claim
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1. A method for delivery of messenger RNA (mRNA) for in vivo production of a protein, comprising administering to a human, a composition comprising an mRNA that encodes a protein or a peptide, wherein the mRNA is encapsulated within a lipid nanoparticle and wherein the administering of the composition results in expression of the protein or peptide encoded by the mRNA that is detectable in serum at least 72 hours after administration, wherein the lipid nanoparticle comprises one or more PEG-modified lipids.

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