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Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system

  • US 10,238,771 B2
  • Filed: 11/07/2013
  • Issued: 03/26/2019
  • Est. Priority Date: 11/08/2012
  • Status: Active Grant
First Claim
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1. A method for treating a bioprosthetic tissue comprising:

  • contacting the bioprosthetic tissue with a nucleophile in the presence of a catalytic system to at least partially cross-link the bioprosthetic tissue;

    wherein the nucleophile directly reacts with tissue functional groups associated with the bioprosthetic tissue, and wherein the nucleophile comprises cystamine;

    wherein the catalytic system comprises at least one or a combination of a fluoride-based salt, a cesium-based salt, a potassium-based salt, or a rubidium-based salt;

    wherein the bioprosthetic tissue is not treated with a glutaraldehyde to at least partially cross-link the bioprosthetic tissue; and

    wherein the bioprosthetic tissue has reduced antigenicity and reduced binding sites for calcium after implantation.

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