Inhaler and methods of use thereof
First Claim
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1. A medicament delivery device comprising:
- a dosing chamber comprising an interior that is configured to contain dry powder medicament received from a medicament container,a transducer confronting the dosing chamber, wherein the dosing chamber and the transducer are acoustically resonant such that the dosing chamber is configured to resonate in response to an activation of the transducer, anda controller electrically coupled to the transducer and configured to send an electrical signal that activates the transducer when the medicament delivery device senses a subject'"'"'s dosing breath,the medicament delivery device having a flow resistance in a range from about 0.040 cmH2O0.5/LPM to about 0.1 cmH2O0.5/LPM at 30 liters per minute (LPM) and capable of delivering a therapeutically effective dose of dry powder medicament in response to between 2-20 tidal inhalations, the dose having a mass median aerodynamic diameter (MMAD) of about 6 microns or less and a fine particle fraction of at least 30%.
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Abstract
A medicament delivery device comprises a dosing chamber configured to contain dry powder medicament, a transducer and a controller electrically coupled to the transducer. The medicament delivery device is capable of delivering a therapeutically effective dose of dry powder medicament in response to between 2-20 tidal inhalations, the dose preferably having a mass median aerodynamic diameter (MMAD) of about 6 microns or less and a fine particle fraction of at least 30%.
169 Citations
30 Claims
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1. A medicament delivery device comprising:
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a dosing chamber comprising an interior that is configured to contain dry powder medicament received from a medicament container, a transducer confronting the dosing chamber, wherein the dosing chamber and the transducer are acoustically resonant such that the dosing chamber is configured to resonate in response to an activation of the transducer, and a controller electrically coupled to the transducer and configured to send an electrical signal that activates the transducer when the medicament delivery device senses a subject'"'"'s dosing breath, the medicament delivery device having a flow resistance in a range from about 0.040 cmH2O0.5/LPM to about 0.1 cmH2O0.5/LPM at 30 liters per minute (LPM) and capable of delivering a therapeutically effective dose of dry powder medicament in response to between 2-20 tidal inhalations, the dose having a mass median aerodynamic diameter (MMAD) of about 6 microns or less and a fine particle fraction of at least 30%. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of treating a respiratory disease or condition, or one or more symptoms thereof, the method comprising:
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inhaling a therapeutically effective dose of dry powder medicament through a medicament delivery device using between 2-20 tidal inhalations over the course of an inhalation cycle, the inhalation cycle comprising dosing breaths, wherein the medicament delivery device comprises a vibratory element that is activated upon each dosing breath and causes dry powder medicament to be aerosolized within a dosing chamber and expelled from one or more openings in the dosing chamber into an air flow conduit, the dosing chamber receiving the dry powder medicament from a medicament container, wherein pressure oscillations in the dosing chamber are sufficiently high at the one or more openings to aerosolize and expel the dry powder medicament via synthetic jetting, the medicament delivery device having a flow resistance in a range from about 0.040 cmH2O0.5/LPM to about 0.1 cmH2O0.5/LPM at 30 liters per minute (LPM) and capable of delivering the dose of dry powder medicament at flow rates at least within a range of about 15 LPM to about 30 LPM, wherein the dose of dry powder medicament administered by the medicament delivery device has a mass median aerodynamic diameter (MMAD) of about 6 microns or less and a fine particle fraction of at least 30%. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A method of increasing FEV1 in a subject, the method comprising:
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inhaling a therapeutically effective dose of dry powder medicament through a medicament delivery device using between 2-20 tidal inhalations over the course of an inhalation cycle, the inhalation cycle comprising dosing breaths, wherein the medicament delivery device comprises a vibratory element that is activated upon each dosing breath and causes dry powder medicament to be aerosolized within a dosing chamber and expelled from one or more openings in the dosing chamber into an air flow conduit, the dosing chamber receiving the dry powder medicament from a medicament container, wherein pressure oscillations in the dosing chamber are sufficiently high at the one or more openings to aerosolize and expel the dry powder medicament via synthetic jetting, the medicament delivery device having a flow resistance in a range from about 0.040 cmH2O0.5/LPM to about 0.1 cmH2O0.5/LPM at 30 liters per minute (LPM) and capable of delivering the dose of dry powder medicament at flow rates at least within a range of about 15 LPM to about 30 LPM, wherein the dose of dry powder medicament delivered by the medicament delivery device has a mass median aerodynamic diameter (MMAD) of about 6 microns or less and a fine particle fraction of at least 30%. - View Dependent Claims (25, 26, 27, 28, 29)
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30. A medicament delivery device comprising:
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a dosing chamber comprising an interior that is configured to contain dry powder medicament, a transducer confronting the dosing chamber, wherein the dosing chamber and the transducer are acoustically resonant such that the dosing chamber is configured to resonate in response to an activation of the transducer, a controller electrically coupled to the transducer and configured to send an electrical signal that activates the transducer when the medicament delivery device senses a subject'"'"'s dosing breath, and an air flow conduit extending from an air inlet to an outlet, the air flow conduit comprising (i) an upstream area disposed upstream from an area of the air flow conduit into which the dry powder medicament is expelled from the dosing chamber, and (ii) a downstream area disposed downstream from the area of the air flow conduit into which the dry powder medicament is expelled from the dosing chamber, the downstream area comprising the outlet and an exit channel disposed about an exit channel axis, wherein the upstream area comprises the air inlet and a first leg of an upper flow path in fluid communication with the exit channel, the first leg disposed about a first leg axis transverse to both the exit channel axis and a dosing chamber axis, wherein the dosing chamber'"'"'s interior shape is at least partially defined by a lower sidewall that transitions to a shoulder, the shoulder transitions to an apex extending away from the lower sidewall, and the apex converges to a point, wherein one or more openings in the dosing chamber are disposed in the apex, and wherein an internal height of the dosing chamber is configured so that pressure oscillation at the one or more openings is sufficiently high to cause the dry powder medicament to become aerosolized and delivered from the one or more openings, the medicament delivery device having a flow resistance in a range from about 0.040 cmH2O0.5/LPM to about 0.1 cmH2O0.5/LPM at 30 liters per minute (LPM) and capable of delivering a therapeutically effective dose of dry powder medicament in response to between 2-20 tidal inhalations, the dose having a mass median aerodynamic diameter (MMAD) of about 6 microns or less and a fine particle fraction of at least 30%.
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Specification