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Solvent-cast microprotrusion arrays containing active ingredient

  • US 10,238,848 B2
  • Filed: 07/01/2015
  • Issued: 03/26/2019
  • Est. Priority Date: 04/16/2007
  • Status: Active Grant
First Claim
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1. A microprotrusion array, comprising:

  • an approximately planar base and a plurality of microprotrusions, wherein the microprotrusions comprise at least a first and a second layer arranged roughly parallel to the plane of the planar base, the first and second layers formed of different polymers, the first layer is contained in a distal end of the microprotrusions and comprised of (i) a biodegradable polymer, (ii) one or more components to facilitate biodegradation selected from sugars, sugar alcohols, cyclodextrins and water-swellable polymers, and (iii) an active ingredient, wherein a ratio of weight percent of the biodegradable polymer to weight percent of the one or more components to facilitate biodegradation is in the range of about 6.25;

    1 to about 1;

    3.75.

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