Method of promoting bone growth by an anti-actriia antibody

• US 10,239,940 B2
• Filed: 09/28/2016
• Issued: 03/26/2019
• Est. Priority Date: 11/23/2005
• Status: Active Grant

• Current Assignee: Acceleron Pharma Inc. (Merck & Co., Inc.)
• Original Assignee: Acceleron Pharma Inc. (Merck & Co., Inc.)
• Inventors: Knopf, John, Seehra, Jasbir
• Primary Examiner(s): Whiteman, Brian
• Application Number:
  US15/278,813
• Publication Number:
  US 20170145085A1
• Time in Patent Office: 909 Days
• CPC Class Codes: A61K 2039/505 comprising antibodies
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 38/179 for growth factors; for growth regulators
• CPC Class Codes: A61K 39/3955 against proteinaceous materials, e.g. enzymes, hormones, lymphokines
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/04 specific for metastasis
• CPC Class Codes: C07K 14/575 Hormones derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin C07K14/665, e.g. corticotropin C07K14/695
• CPC Class Codes: C07K 14/71 for growth factors; for growth regulators
• CPC Class Codes: C07K 16/22 against growth factors ; against growth regulators
• CPC Class Codes: C07K 2317/76 Antagonist effect on antigen, e.g. neutralization or inhibition of binding
• CPC Class Codes: C07K 2319/30 Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
• CPC Class Codes: C12N 15/1136 against growth factors, growth regulators, cytokines, lymphokines or hormones
• CPC Class Codes: C12N 15/1138 against receptors or cell surface proteins
• CPC Class Codes: C12N 2310/11 Antisense

Abstract

In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.

Claims

1. A method for promoting bone growth, increasing bone density or increasing bone strength, the method comprising administering to a subject in need thereof an effective amount of an antisense nucleic acid comprising a sequence complementary to a nucleotide sequence encoding any one of the following:

activin A, activin B, or ActRIIA.

2. The method of claim 1, wherein the antisense nucleic acid comprises a sequence complementary to a nucleotide sequence encoding activin A.

3. The method of claim 1, wherein the antisense nucleic acid comprises a sequence complementary to a nucleotide sequence encoding activin B.

4. The method of claim 1, wherein the antisense nucleic acid comprises a sequence complementary to a nucleotide sequence encoding ActRIIA.

5. The method of claim 1, wherein the method is for promoting bone growth.

6. The method of claim 1, wherein the method is for increasing bone density.

7. The method of claim 1, wherein the method is for increasing bone strength.

8. The method of claim 1, wherein the antisense nucleic acid has a length of 15 to 30 nucleotides.

9. The method of claim 1, wherein the antisense nucleic acid is DNA.

10. The method of claim 1, wherein the antisense nucleic acid is RNA.