Biological sample measuring device

• US 10,241,069 B2
• Filed: 10/30/2015
• Issued: 03/26/2019
• Est. Priority Date: 02/23/2011
• Status: Active Grant

• Current Assignee: PHC Holdings Corporation
• Original Assignee: PHC Holdings Corporation
• Inventors: Yoshioka, Eriko, Shinno, Teppei, Hironaka, Shouko
• Primary Examiner(s): Dinh, Bach T
• Application Number:
  US14/927,470
• Publication Number:
  US 20160047776A1
• Time in Patent Office: 1,243 Days
• Field of Search: 20440301-40315, 2057775, 205792
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: C12M 1/34 Measuring or testing with condition measuring or sensing means, e.g. colony counters
• CPC Class Codes: C12Q 1/00 Measuring or testing processes involving enzymes, nucleic acids or microorganisms measuring or testing apparatus with condition measuring or sensing means, e.g. colony counters, C12M1/34; Compositions therefor; Processes of preparing such compositions
• CPC Class Codes: G01N 27/3271 Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood amperometry per se G01N27/49; aspects concerning the enzyme reagent C12Q1/001
• CPC Class Codes: G01N 27/3273 Devices therefor, e.g. test element readers, circuitry details not specific to biochemical electrodes G01N33/4875
• CPC Class Codes: G01N 27/416 Systems G01N27/27 takes precedence
• CPC Class Codes: G01N 27/4175 Calibrating or checking the analyser
• CPC Class Codes: G01N 33/49 Blood chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80
• CPC Class Codes: G06F 2218/00 Aspects of pattern recognition specially adapted for signal processing
• CPC Class Codes: G16B 40/00 ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
• CPC Class Codes: H01J 49/0036 Step by step routines describing the handling of the data generated during a measurement

Abstract

A biological sample measuring device in which a deposited biological sample is introduced into a capillary, a biological sample measuring sensor in which a reagent and the biological sample provided is mounted, and the biological sample is measured. The biological sample measuring device comprises a mounting portion, a voltage application section, and a detection component. The biological sample measuring sensor is mounted to the mounting portion. The voltage application section applies a measurement voltage to a plurality of electrodes disposed along the capillary. The detection component eliminates the effect of seepage of the biological sample by pass-around at the end of the capillary, or the effect whereby the plasma component seeps into the reagent, and detects the degree to which the biological sample is introduced into the capillary, based on the output result for the voltage applied by the voltage application section to the electrodes.

Claims

1. A biological sample measuring device in which a biological sample measuring sensor is mounted, and the biological sample is measured, said biological sample measuring device comprising:

a mounting portion to which the biological sample measuring sensor is mounted;

a voltage application section that applies voltage to a plurality of electrodes disposed along a capillary in the biological sample measuring sensor; and

a controller that determines whether the capillary is in a properly filled state or in a state in which pass-around or seepage has occurred and detects a degree to which the biological sample is introduced into the capillary by;

(a) applying a voltage to the electrodes and obtaining a current value,

(b) obtaining a first output value from the current value, and

when the first output value exceeds a first threshold, the controller concludes that the capillary has been filled with the biological sample, and calculates a threshold determination to determine if the threshold determination exceeds a second threshold, the second threshold indicating a sufficient quantity of the biological sample in the capillary; and

when it has been concluded that the capillary does not contain the sufficient quantity of the biological sample, the controller recommends an additional deposit of the biological sample and determines whether a second output value exceeds the first threshold, and

again calculates the threshold determination to determine if the threshold determination exceeds the second threshold, the second threshold indicating the sufficient quantity of the biological sample in the capillary.