Laboratory instrument and method of using the same

• US 10,241,123 B2
• Filed: 11/29/2016
• Issued: 03/26/2019
• Est. Priority Date: 11/30/2015
• Status: Active Grant

• Current Assignee: Roche Molecular Systems (Roche Holding AG)
• Original Assignee: Roche Molecular Systems (Roche Holding AG)
• Inventors: Barmettler, Kurt, Peter, Andre
• Primary Examiner(s): Wecker, Jennifer
• Application Number:
  US15/364,048
• Publication Number:
  US 20170153260A1
• Time in Patent Office: 847 Days
• CPC Class Codes: B01L 3/021 Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
• CPC Class Codes: G01N 2035/00752 bar codes
• CPC Class Codes: G01N 2035/00782 reprogrammmable code
• CPC Class Codes: G01N 2035/0412 Block or rack elements with a single row of samples
• CPC Class Codes: G01N 2035/0413 moving in one dimension
• CPC Class Codes: G01N 2035/1051 for transporting containers, e.g. retained by friction
• CPC Class Codes: G01N 35/00732 Identification of carriers, materials or components in automatic analysers
• CPC Class Codes: G01N 35/0099 comprising robots or similar manipulators robots per se B25J
• CPC Class Codes: G01N 35/026 having blocks or racks of reaction cells or cuvettes
• CPC Class Codes: G01N 35/1002 Reagent dispensers

Abstract

Disclosed is a method of operating a laboratory instrument (100, 1000), wherein the laboratory instrument is configured for receiving a sample rack (112) with one or more sample tubes (126), wherein the laboratory instrument comprises a robotic head (106) for bringing a pipettor (108) into fluidic contact with the one or more sample tubes when the sample rack is in an operating position (122), wherein the robotic head is configured for loading the sample rack into the operating position, and wherein the method comprises the steps of: receiving (200) the sample rack by the laboratory instrument; and loading (202) the rack into the operating position using the robotic head.

Claims

1. A method of operating a laboratory instrument, wherein the laboratory instrument is configured to receive a sample rack having one or more sample tubes, the laboratory instrument comprising a robotic head operably connected to a pipettor capable of being brought into fluidic contact with the one or more sample tubes when the sample rack is in an operating position in the laboratory instrument, wherein the laboratory instrument receives the sample rack along only one direction, an insertion direction, and wherein the method comprises the steps of:

(a) receiving the sample rack by the laboratory instrument; and

(b) loading, via the robotic head, the sample rack into the operating position.

2. The method of claim 1, wherein the laboratory instrument further comprises an identification tag reader and the one or more sample tubes have a tube identification tag, and loading step (b) further comprises loading the sample rack into the operating position to enable the identification tag reader to read the tube identification tag on the one or more sample tubes.

3. The method of claim 2, wherein the sample rack comprises an attachment position, wherein the pipettor is configured to mate with the attachment position and the laboratory instrument further comprises an insertion guide configured to receive the sample rack along the insertion direction in the laboratory instrument, the insertion guide having an opening, the method further comprising the steps of:

(a) mating the robotic head with the attachment position;

(b) moving, via the robotic head, the sample rack in the insertion guide along the insertion direction, to align the tube identification tag with the identification tag reader; and

(c) reading, via the identification tag reader, the tube identification tag.

4. The method of claim 3, wherein an insertion slot has a first optically visible marking, wherein the sample rack has a second optically visible marking, wherein the step of moving the sample rack into the insertion guide along the insertion direction is performed such that the first optically visible marking is substantially aligned with the second optically visible marking.

5. The method of claim 4, wherein the moving step (b) further comprises the steps of:

controlling the robotic head to move the pipettor in the insertion guide along the insertion direction from a starting position towards the opening;

detecting a contact event between the pipettor and an insertion end of the sample rack using a contact detector; and

controlling the robotic head to halt movement in the insertion direction when a contact event is detected.

6. The method of claim 5, further comprising the step of controlling the robotic head to move the sample rack partially out of the insertion guide to position the sample rack to a predefined insertion depth.

7. A laboratory instrument configured to receive a sample rack with one or more sample tubes, wherein the laboratory instrument comprises an insertion guide configured to receive the sample rack along a only one direction, an insertion direction, and wherein a robotic head operably connected to a pipettor and configured to (a) load the sample rack into an operating position within the laboratory instrument, and (b) bring the pipettor into fluidic contact with the one or more sample tubes when the sample rack is in an operating position.

8. The laboratory instrument of claim 7, wherein the laboratory instrument further comprises an identification tag reader and the one or more sample tubes have a tube identification tag, and the identification tag reader is configured to read the tube identification tags on each of the one or more sample tubes when wherein the sample rack is loaded into the operating position.

9. The laboratory instrument of claim 8, wherein the sample rack further comprises multiple sample tube receptacles, wherein each sample tube receptacle is configured to receive a sample tube having a sample tube identification tag.

10. The laboratory instrument of claim 8, wherein the laboratory instrument further comprises a control unit and the sample rack comprises an attachment position, wherein the control unit is configured to (a) control the robotic head to mate with the attachment position;

(b) control the robotic head to move the sample rack in the insertion guide along the insertion direction to enable the tube identification tag to be read by the identification rag reader; and

(c) read the tube identification tag with the identification tag reader as the sample rack is moved into the insertion guide.

11. The laboratory instrument of claim 8, wherein the robotic head is configured to move the pipettor in the insertion guide along the insertion direction.

12. The laboratory instrument of claim 11, wherein the laboratory instrument further comprises a contact detector for detecting contact between the pipettor and an insertion end of the sample rack, wherein the controller is configured to:

(a) control the robotic arm to move the pipettor in the insertion guide, wherein the pipettor is moved in the insertion guide along the insertion direction from a starting position towards the opening;

(b) detect a contact event between the pipettor and an insertion end of the sample rack using the contact detector; and

(c) control the robotic arm to halt movement in the insertion direction when the contact event is detected.

13. The laboratory instrument of claim 10, wherein the control unit is further configured to control the robotic head to move the sample rack at least partially out of the insertion guide to position the sample rack to a predefined insertion depth.

14. The laboratory instrument of claim 8, further comprising a hinged lid to cover the opening of the insertion guide, wherein the hinged lid is configured to be in an open position and a closed position, and when the hinged lid is in the open position, the hinged lid can support the sample rack during insertion into the insertion guide.

15. The laboratory instrument of claim 8, wherein the identification tag reader comprises a bar code reader, an RFID reader, or combinations thereof, and correspondingly, the tube identification tag comprises a bar code and RFID tag or combinations thereof.

16. A computer program product comprising machine executable code for execution by a controller for a laboratory instrument, wherein the laboratory instrument comprises an insertion guide configured to receive a sample rack along only one direction, an insertion direction, in the laboratory instrument, and wherein the sample comprises one or more sample tubes and the controller is configured to (a) control a robotic head to load the sample rack into an operating position in the laboratory instrument;

and (b) control a robotic head to bring a pipettor into fluidic contact with the one or more sample tubes when the sample rack is in the operating position.