Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography

• US 10,244,939 B2
• Filed: 06/01/2018
• Issued: 04/02/2019
• Est. Priority Date: 12/21/2012
• Status: Active Grant

• Current Assignee: TearScience Inc. (Johnson & Johnson)
• Original Assignee: TearScience Inc. (Johnson & Johnson)
• Inventors: Grenon, Stephen M., Korb, Donald R.
• Primary Examiner(s): Pinkney, Dawayne
• Application Number:
  US15/995,612
• Publication Number:
  US 20180279871A1
• Time in Patent Office: 305 Days
• Field of Search: 351206, 351200, 351205, 351209-210, 351221-223, 351245-246, 351212, 351208, 351160 R, 351159, 600247, 600356, 600346, 600476, 600425
• CPC Class Codes: A61B 3/0008 provided with illuminating means A61B3/117 takes precedence; goniolenses used for laser treatment A61F9/009; illuminating means for optical instruments G02B27/00
• CPC Class Codes: A61B 3/0025 characterised by electronic signal processing, e.g. eye models
• CPC Class Codes: A61B 3/0058 for multiple images
• CPC Class Codes: A61B 3/1005 for measuring distances inside the eye, e.g. thickness of the cornea A61B3/11 takes precedence
• CPC Class Codes: A61B 3/101 for examining the tear film
• CPC Class Codes: A61B 3/107 for determining the shape or measuring the curvature of the cornea
• CPC Class Codes: A61B 3/14 Arrangements specially adapted for eye photography apparatus or arrangements for taking photographs per se G03B
• CPC Class Codes: G02B 26/023 comprising movable attenuating elements, e.g. neutral density filters

Abstract

Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including the lipid layer thickness (LLT) and/or the aqueous layer thickness (ALT). The TFLT can be used to diagnose dry eye syndrome (DES). Certain embodiments also include ocular topography devices, systems and methods for deducing corneal shape by capturing an image of a target reflecting from the surface of the cornea. The image of the target contains topography information that is reviewable by a clinician to diagnose the health of the patient'"'"'s eye by detecting corneal aberrations and/or abnormalities in corneal shape. Certain embodiments also include a combination of the OSI and ocular topography devices, systems and methods to provide imaging that can be used to yield a combined diagnosis of the patient'"'"'s tear film and corneal shape.

Claims

1. An apparatus for imaging an eye, comprising:

a control system configured to;

(a) modulate light from a multi-wavelength light source to project a first pattern onto the eye;

(b) receive at an imaging device, at least one first image containing at least one first signal associated with an ocular property of the eye comprising emitted light reflected from at least one first portion of the eye;

(c) modulate light from the multi-wavelength light source to project a second pattern onto the eye, such that at least one second portion of the eye receives the emitted light from the multi-wavelength light source; and

(d) receive at the imaging device, at least one second image containing at least one second signal associated with the ocular property of the eye comprising the emitted light reflected from the at least one second portion of the eye;

wherein;

the at least one first signal is optical wave interference of specularly reflected light from an ocular tear film combined with at least one background signal; and

the control system is configured to receive the at least one first image by being configured to;

capture a first pattern of the specularly reflected light including the at least one background signal from at least one first portion of the ocular tear film in the at least one first image by the imaging device; and

capture a second pattern of the specularly reflected light including the at least one background signal from at least one second portion of the ocular tear film in the at least one second image by the imaging device.

2. The apparatus of claim 1, further comprising a light modulator system communicatively coupled to the control system to modulate light from the multi-wavelength light source to alternately project the first pattern and the second pattern onto the eye thereby generating the at least one first signal and the at least one second signal of the ocular property.

3. The apparatus of claim 2, wherein the light modulator system includes a disk disposed between the imaging device and the eye for sequentially projecting the first pattern and the second pattern onto the eye when the disk is illuminated, and wherein the disk includes a central aperture for the imaging device to receive light reflected from the eye.

4. The apparatus of claim 3, wherein the disk is patterned with a plurality of concentric circles having alternating opaque and translucent sections with edges that form radials to form the first pattern comprising a first circular pattern and the second pattern comprising a second circular pattern.

5. The apparatus of claim 4, wherein the light modulator system further includes an electric motor and a drive mechanism for rotating the disk to alternately generate the first pattern while the imaging device captures the at least one first image containing the at least one first signal of the ocular property and to generate the second pattern while the imaging device captures the at least one second image containing the at least one second signal of the ocular property.

6. The apparatus of claim 3, wherein the disk is a frusto-conical shaped disk having an open major base that faces the eye and an open minor base that faces the imaging device.

7. The apparatus of claim 3, wherein the disk includes pixels that when illuminated by the multi-wavelength light source project the first pattern in response to a first control signal and project the second pattern in response to a second control signal.

8. The apparatus of claim 1, wherein the multi-wavelength light source is comprised of a multi-wavelength Lambertian light source configured to uniformly or substantially uniformly illuminate the eye.

9. The apparatus of claim 1, wherein the control system is further configured to display at least one of the at least one first image and the at least one second image on a visual display.

10. The apparatus of claim 9, wherein the control system is further configured to display the at least one of the at least one first image and the at least one second image overlaid onto the at least one of the at least one first image and the at least one second image on the visual display.

11. The apparatus of claim 1, wherein the ocular property is comprised of a thickness of the ocular tear film.

12. The apparatus of claim 1, wherein the imaging device is configured to capture the at least one second image when the multi-wavelength light source is not illuminating the at least one second portion of the ocular tear film.

13. The apparatus of claim 1, wherein the imaging device is configured to capture the at least one second image when the multi-wavelength light source is illuminating the at least one second portion of the ocular tear film.

14. The apparatus of claim 1, wherein the control system is configured to receive the at least one second image containing the at least one background signal from the ocular tear film captured by the imaging device by being configured to:

capture the at least one background signal from the at least one second portion in the first pattern in the at least one first image; and

capture the at least one background signal from the at least one first portion of the second pattern in the at least one second image.

15. The apparatus of claim 14, wherein the control system is further configured to combine the at least one first image to the at least one second image to form at least one resulting image in a pattern containing the optical wave interference of the specularly reflected light from the ocular tear film with the at least one background signal removed or reduced.

16. The apparatus of claim 15, wherein the control system is further configured to:

(e) convert at least a portion of the at least one resulting image representing the optical wave interference of the specularly reflected light from at least a portion of the ocular tear film into at least one color-based value;

(f) compare the at least one color-based value to a tear film layer optical wave interference model; and

(g) measure a tear film layer thickness (TFLT) of the at least a portion of the ocular tear film based on the comparison of the at least one color-based value to the tear film layer optical wave interference model.

17. The apparatus of claim 16, wherein the control system configured to measure the TFLT of the at least a portion of the ocular tear film based on the comparison of the at least one color-based value to the tear film layer optical wave interference model further comprises measuring at least one of a lipid layer thickness (LLT) and an aqueous layer thickness (ALT).

18. The apparatus of claim 1, wherein the at least one first signal and the at least one second signal are also associated with a second ocular property of the eye that is a corneal shape.

19. The apparatus of claim 18, wherein the first pattern and the second pattern are generated as a respective first circular pattern and a second circular pattern by modulating light with a disk comprised of a plurality of concentric circles having alternating opaque and translucent sections including edges that form radials.

20. The apparatus of claim 18, wherein the control system is further configured to subtract the at least one second image from the at least one first image to generate at least one resulting image.

21. The apparatus of claim 1, wherein the ocular property is a corneal shape and the at least one first signal is associated with a corneal shape for the at least one first portion of the eye, and the at least one second signal is associated with a corneal shape for the at least one second portion of the eye.

22. The apparatus of claim 21, wherein the first pattern and the second pattern are generated by modulating light with a disk comprised of a plurality of concentric circles having alternating opaque and translucent sections including edges that form radials.

23. The apparatus of claim 21, wherein the at least one first portion of the eye and the at least one second portion of the eye are comprised of equal or approximately equal areas.

24. The apparatus of claim 21, wherein the control system is further configured to subtract the at least one second image from the at least one first image to generate at least one resulting image.

25. The apparatus of claim 1, wherein:

the first pattern comprises a first rectangular pattern; and

the second pattern comprises a second rectangular pattern.