System and method for early detection of mild traumatic brain injury
First Claim
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1. A device for detecting brain injury by measuring sleep movement parameters comprising:
- a plurality of sensors, each operative at a sampling rate of at least 10 Hz to generate a plurality of temporally-associated data signals relating to sleep movements of a subject, said sensors arranged to provide both integrated and spatially segregated movement estimation for said subject, at least some of said sensors having a sensitivity capable of detecting load variances as small as 1 g;
a signal conditioning module including a conditioning circuit in communication with said plurality of sensors, said signal conditioning module operative to condition said data signals;
a processor in communication with said signal conditioning module, said processor operative to analyze said conditioned data, said processor having a module programmed for parsing the data into a plurality of bins of defined temporal duration, at least some of which bins are 60 seconds or less in duration, and for comparing the average values of each bin to differentiate among (a) bouts of quiescence, (b) bouts of macro-structural movements indicative of sleep or wake cycles, or sleep fragmentation; and
(c) bouts of micro-structural movements, the micro-structural movements being useful to detect brain injury; and
a non-inverting resistor-ladder amplifier as an interface between each of the plurality of sensors and the processor.
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Abstract
A wireless system and methods for non-invasive detection of brain injury that includes a detection device for reliable monitoring and analyzing of sleep movement in comparison with normal sleep movement architecture to identify dampened sleep movement patterns indicative of brain injury.
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Citations
22 Claims
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1. A device for detecting brain injury by measuring sleep movement parameters comprising:
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a plurality of sensors, each operative at a sampling rate of at least 10 Hz to generate a plurality of temporally-associated data signals relating to sleep movements of a subject, said sensors arranged to provide both integrated and spatially segregated movement estimation for said subject, at least some of said sensors having a sensitivity capable of detecting load variances as small as 1 g; a signal conditioning module including a conditioning circuit in communication with said plurality of sensors, said signal conditioning module operative to condition said data signals; a processor in communication with said signal conditioning module, said processor operative to analyze said conditioned data, said processor having a module programmed for parsing the data into a plurality of bins of defined temporal duration, at least some of which bins are 60 seconds or less in duration, and for comparing the average values of each bin to differentiate among (a) bouts of quiescence, (b) bouts of macro-structural movements indicative of sleep or wake cycles, or sleep fragmentation; and
(c) bouts of micro-structural movements, the micro-structural movements being useful to detect brain injury; anda non-inverting resistor-ladder amplifier as an interface between each of the plurality of sensors and the processor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of testing a subject for brain injury comprising the steps of:
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(a) monitoring the sleep movements of a subject using movement sensors operable at a sampling rate of at least 10 Hz to generate a plurality of temporally-associated data signals relating to sleep movements, wherein an output of the movement sensors is converted in a resistance-to-voltage amplifier; (b) parsing the data at least once into a plurality of bins of defined temporal duration of 60 seconds or less, and determining an average value for each bin to differentiate bouts of micro-structural movements from bouts of quiescence and bouts of macro-structural movements; (c) comparing the values for bouts of micro-structural movements to a threshold value that is indicative of brain injury; and (d) assigning a determination of brain injury according to the outcome of the comparison. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification