Methods for facilitating revascularization of occlusion

• US 10,245,050 B2
• Filed: 11/01/2016
• Issued: 04/02/2019
• Est. Priority Date: 09/30/2016
• Status: Active Grant

• Current Assignee: Teleflex Life Sciences LLC (Teleflex Incorporated)
• Original Assignee: Teleflex Innovations S.a.r.l. (Teleflex Incorporated)
• Inventors: Kugler, Chad
• Primary Examiner(s): Dang, Phong Son H
• Application Number:
  US15/340,026
• Publication Number:
  US 20180092650A1
• Time in Patent Office: 882 Days
• CPC Class Codes: A61B 17/22 Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for dilators A61M29/00
• CPC Class Codes: A61B 2017/22001 Angioplasty, e.g. PCTA
• CPC Class Codes: A61B 2017/22038 with a guide wire
• CPC Class Codes: A61B 2017/22041 outside the catheter
• CPC Class Codes: A61B 2017/22042 Details of the tip of the guide wire
• CPC Class Codes: A61B 2017/22044 with a pointed tip
• CPC Class Codes: A61B 2017/22062 to be filled with liquid
• CPC Class Codes: A61B 2017/22067 Blocking; Occlusion A61B2017/22054 takes precedence
• CPC Class Codes: A61B 2017/22095 accessing a blood vessel true lumen from the sub-intimal space

Abstract

This patent document discloses methods for facilitating revascularization of an occlusion in a blood vessel. A method can include engaging a first guide within a vessel wall adjacent to a distal cap of the occlusion and advancing the first guide, in a retrograde direction, to a subintimal position near a proximal cap of the occlusion. A second guide can be engaged within the proximal cap or the vessel wall adjacent to the proximal cap and advanced, in an antegrade direction, until its distal end is near or axially overlaps a distal end of the first guide. A first vessel lumen, formed by advancement of the first guide, and a second vessel lumen, formed by advancement of the second guide, can be connected by inflating a balloon positioned at or near the distal end of the second guide. The distal end of the first guide can be received by a passage of the inflated balloon, the balloon can be subsequently deflated to collapse the passage and clamp a passage wall against the first guide'"'"'s distal end, and the balloon and first guide can be pulled into an antegrade guide catheter.

Claims

1. A method, comprising:

engaging a first guide within a vessel wall adjacent to a distal cap of an occlusion and advancing the first guide, in a retrograde direction, to a subintimal position near a proximal cap of the occlusion;

engaging a second guide within the proximal cap or the vessel wall adjacent to the proximal cap and advancing the second guide, in an antegrade direction, until its distal end is near or axially overlaps a distal end of the first guide;

connecting a first vessel lumen, formed by advancement of the first guide, and a second vessel lumen, formed by advancement of the second guide, including inflating a balloon positioned at or near the distal end of the second guide; and

receiving the distal end of the first guide within a passage of the inflated balloon.

2. The method of claim 1, further comprising advancing the first guide, in the retrograde direction, toward the distal cap prior to its engagement within the vessel wall.

3. The method of claim 1, further comprising advancing the second guide, in the antegrade direction, toward the proximal cap prior to its engagement within the proximal cap or the vessel wall adjacent to the proximal cap.

4. The method of claim 1, wherein engaging the first guide within the vessel wall includes engaging a retrograde-delivered guidewire within the vessel wall, and engaging the second guide within the proximal cap or the vessel wall adjacent to the proximal cap includes engaging an antegrade-delivered guidewire within the proximal cap or the vessel wall adjacent to the proximal cap.

5. The method of claim 4, further comprising advancing the balloon to the position at or near the distal end of the second guide along the antegrade-delivered guidewire.

6. The method of claim 1, wherein engaging the first guide within the vessel wall includes engaging a retrograde-delivered specialty catheter within the vessel wall, and engaging the second guide within the proximal cap or the vessel wall adjacent to the proximal cap includes engaging an antegrade-delivered specialty catheter within the proximal cap or the vessel wall adjacent to the proximal cap.

7. The method claim 1, further comprising deflating the balloon and collapsing the passage, including clamping a wall of the collapsed passage against the distal end of the first guide.

8. The method of claim 7, further comprising guiding the distal end of the first guide into an antegrade guide catheter by pulling the balloon, in the retrograde direction, into the antegrade guide catheter.

9. The method of claim 8, further comprising advancing, in the retrograde direction, a specialty catheter over the first guide and into the antegrade guide catheter to complete a pathway between a proximal end of the specialty catheter and a proximal end of the antegrade guide catheter.

10. The method of claim 9, further comprising removing the first guide by pulling on its proximal end, in the antegrade direction.

11. The method of claim 10, further comprising advancing a third guide having a length longer than a length of the first guide, in the retrograde direction, through the specialty catheter and the antegrade guide catheter and out the proximal end of the antegrade guide catheter.

12. The method of claim 11, further comprising performing a revascularization procedure using a treatment device advanced in the antegrade direction along the third guide.

13. The method of claim 1, wherein inflating the balloon includes inflating a tube coiled in a helical manner around a central axis into a series of windings, with adjacent windings stacked against and bonded to each other.

14. The method of claim 13, further comprising advancing the balloon to the position at or near the distal end of the second guide using an elongate shaft eccentrically positioned relative to the helically coiled inflatable tube.

15. The method of claim 14, wherein inflating the balloon includes providing inflation fluid through a lumen of the elongate shaft.

16. The method of claim 15, wherein advancing the balloon to the position at or near the distal end of the second guide includes using a guidewire lumen, separate from the lumen of the elongate shaft and the passage of the inflated balloon.

17. The method of claim 1, wherein inflating the balloon includes forming the passage.

18. The method of claim 17, wherein forming the passage includes forming a cavity having a diameter ranging from 2 mm-6 mm and a length ranging from 10 mm-50 mm.

19. A method of facilitating treatment of a blood vessel having a vascular wall, an innermost surface of the vascular wall defining a vascular lumen having an occlusion therein, the vascular wall having an outermost surface further from the vascular lumen, comprising:

advancing a retrograde-delivered guidewire into subintimal space within the vascular wall and adjacent to a distal cap of the occlusion until its distal end is near a proximal cap of the occlusion;

advancing an antegrade-delivered guidewire into subintimal space within the vascular wall or within the proximal cap until its distal end is near or overlaps the distal end of the retrograde-delivered guidewire;

connecting a first vessel lumen, formed by advancement of the retrograde-delivered guidewire, and a second vessel lumen, formed by advancement of the antegrade-delivered guidewire, including inflating a balloon positioned at or near the distal end of the antegrade-delivered guidewire;

further advancing the retrograde-delivered guidewire into a passage of the inflated balloon; and

deflating the balloon and collapsing the passage, including capturing the distal end of the retrograde-delivered guidewire using a wall of the collapsed passage.

20. The method of claim 19, further comprising advancing the retrograde-delivered guidewire through a proximal end of a collateral channel to the distal cap prior to its advancement into subintimal space.

21. The method of claim 19, further comprising guiding the distal end of the retrograde-delivered guidewire into an antegrade guide catheter through pulling of the balloon into the antegrade guide catheter.

22. The method of claim 19, wherein inflating the balloon includes distending a portion of tissue along the innermost surface of the vascular wall.

23. The method of claim 19, wherein inflating the balloon includes selectively forming a passage between the subintimal space and the vascular lumen.

24. The method of claim 19, further comprising performing an interventional procedure over a guidewire disposed partially in the subintimal space.