Drug delivery via mechanical vibration balloon

• US 10,245,051 B2
• Filed: 12/20/2013
• Issued: 04/02/2019
• Est. Priority Date: 12/28/2012
• Status: Active Grant

• Current Assignee: Bard Peripheral Vascular Incorporated (Becton, Dickinson & Co)
• Original Assignee: Bard Peripheral Vascular Incorporated (Becton, Dickinson & Co)
• Inventors: Spano, Richard Samuel
• Primary Examiner(s): Osinski, Bradley J
• Assistant Examiner(s): Shah, Nilay J
• Application Number:
  US14/758,557
• Publication Number:
  US 20150343191A1
• Time in Patent Office: 1,929 Days
• CPC Class Codes: A61B 17/22012 in direct contact with, or very close to, the obstruction or concrement for removing obstructions in blood vessels by laser A61B18/245
• CPC Class Codes: A61B 17/320068 using mechanical vibrations, e.g. ultrasonic A61B17/22012 takes precedence; dental tooth drilling devices operated by vibration A61C3/03; removing intra-ocular material using mechanical vibrations A61F9/00745
• CPC Class Codes: A61B 2017/22014 the ultrasound transducer being outside patient's body; with an ultrasound transmission member; with a wave guide; with a vibrated guide wire not applied in A61B17/22012
• CPC Class Codes: A61B 2017/22039 eccentric
• CPC Class Codes: A61B 2017/22061 for spreading elements apart
• CPC Class Codes: A61B 2017/320088 with acoustic insulation, e.g. elements for damping vibrations between horn and surrounding sheath
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1084 having features for increasing the shape stability, the reproducibility or for limiting expansion, e.g. containments, wrapped around fibres, yarns or strands
• CPC Class Codes: A61M 2025/109 having balloons for removing solid matters, e.g. by grasping or scraping plaque, thrombus or other matters that obstruct the flow
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Abstract

A drug coated inflatable balloon catheter (200) configured to vibrate is disclosed. The vibration can dislodge the drug from the balloon. The vibration can also improve delivery of the drug to deeper layers of a vessel wall. The balloon catheter can include one or more support wires. The support wires can be coupled to an ultrasound transmission member (120). The ultrasound transmission member can transmit ultrasonic vibrations to the support wires and/or the balloon wall.

Claims

1. A drug delivery balloon catheter comprising:

an ultrasound transmission member having a proximal end and a distal end;

a generator configured to provide longitudinal vibrations to the ultrasound transmission member through the proximal end of the ultrasound transmission member coupled to the generator;

a balloon coupled to the distal end of the ultrasound transmission member and being movable between an inflated state and a deflated state; and

at least one wire coupled to the ultrasound transmission member and the balloon so as to transmit the longitudinal vibrations parallel to the balloon catheter from the ultrasound transmission member to the balloon such that the balloon is longitudinally vibrated at least when the balloon is in the inflated state.

2. The device of claim 1, further comprising a catheter body having a distal end and at least one lumen extending longitudinally therethrough, the catheter body surrounding at least a portion of the ultrasound transmission member and in fluid connection with the balloon.

3. The device of claim 1, wherein the at least one wire has a proximal end joined to a first location on the ultrasound transmission member and a distal end joined to a second location on the ultrasound transmission member, the second location spaced distally from the first location.

4. The device of claim 3, wherein the first location is proximate a proximal end of the balloon and the second location is proximate a distal end of the device.

5. The device of claim 3, wherein the at least one wire is directly joined to an exterior surface of the ultrasound transmission member at the first location and at the second location.

6. The device of claim 3, wherein the at least one wire is radially distanced from and separated from the ultrasound transmission member between the first location and the second location in the inflated state.

7. The device of claim 1, wherein the device includes four wires coupled to the ultrasound transmission member and contacting a surface of the balloon.

8. The device of claim 1, wherein the device includes twelve wires coupled to the ultrasound transmission member and contacting a surface of the balloon.

9. The device of claim 1, wherein the at least one wire contacts an inner surface of the balloon.

10. The device of claim 1, wherein the at least one wire contacts an outer surface of the balloon.

11. The device of claim 1, wherein the at least one wire is imbedded within the balloon.

12. The device of claim 1, wherein the balloon is coated with at least one therapeutic.

13. The device of claim 12, wherein the at least one therapeutic includes an antistenosis drug.

14. A drug-delivery device for vessels comprising:

a catheter body having at least one lumen extending longitudinally therethrough;

an elongate ultrasound transmission member extending longitudinally through the lumen; and

a drug-coated balloon having at least one support wire coupled to the ultrasound transmission member so as to transmit longitudinal vibrations parallel to the catheter body to the drug-coated balloon such that the drug-coated balloon is longitudinally vibrated.

15. The device of claim 14, wherein the ultrasound transmission member extends longitudinally through the drug-coated balloon.