Anterior chamber drug-eluting ocular implant
First Claim
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1. A drug delivery ocular implant comprising:
- an elongate outer shell having a proximal end, and a distal end, and being shaped to define an interior space;
at least one drug positioned within said interior space;
wherein said outer shell has at least a first thickness and an outer diameter;
wherein said outer shell comprises one or more regions of drug release;
wherein said implant is shaped and sized so as to be suitable for implantation within an anterior chamber of an eye;
wherein said implant is shaped and sized to be positioned fully in an irido-corneal angle of the anterior chamber of the eye;
wherein said implant is configured without one or more anchoring protrusions, wherein the outer shell provides sufficient friction against tissue of the irido-corneal angle to hold the implant in position in the irido-corneal angle; and
wherein said implant is configured to be deformed from a straightened to an arcuate shape for retention within the irido-corneal angle.
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Abstract
Disclosed herein are drug delivery ocular implants comprising an elongate outer shell having a proximal end, and distal end and being shaped to define an interior lumen, at least one therepautic agent positioned within the lumen, wherein the outer shell has at least a first thickness, the outer shell comprises one or more regions of drug release, and the implant is dimensioned for implantation within the anterior chamber of the eye.
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Citations
32 Claims
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1. A drug delivery ocular implant comprising:
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an elongate outer shell having a proximal end, and a distal end, and being shaped to define an interior space; at least one drug positioned within said interior space; wherein said outer shell has at least a first thickness and an outer diameter; wherein said outer shell comprises one or more regions of drug release; wherein said implant is shaped and sized so as to be suitable for implantation within an anterior chamber of an eye; wherein said implant is shaped and sized to be positioned fully in an irido-corneal angle of the anterior chamber of the eye; wherein said implant is configured without one or more anchoring protrusions, wherein the outer shell provides sufficient friction against tissue of the irido-corneal angle to hold the implant in position in the irido-corneal angle; and wherein said implant is configured to be deformed from a straightened to an arcuate shape for retention within the irido-corneal angle. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A drug delivery ocular implant comprising:
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an elongate polymeric body comprising an outer shell having a proximal end, and a distal end and being shaped to define an interior space; at least one drug positioned within said interior space; wherein said outer shell has at least a first thickness and an outer diameter; wherein said outer shell comprises one or more regions of drug release; wherein said implant is shaped and sized so as to be suitable for implantation within an anterior chamber of an eye; wherein said implant is shaped and sized to be positioned fully in an irido-corneal angle of the anterior chamber of the eye and fully within the anterior chamber of the eye; wherein said implant is configured with one or more anchoring protrusions, wherein the one or more anchoring protrusions hold the implant in position in the irido-corneal angle; and wherein said implant is configured to be deformed from a straightened to an arcuate shape for retention within the irido-corneal angle. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A drug delivery ocular implant comprising:
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an elongate polymeric body comprising a proximal end and a distal end, a polymer, and at least one drug blended with the polymer of the elongate polymeric body; wherein said elongate polymeric body is biodegradable; wherein the at least one drug comprises one or more of travoprost or dexamethasone; wherein said implant is shaped and sized so as to be suitable for implantation within an anterior chamber of an eye; wherein said implant is shaped and sized to be positioned fully in an irido-corneal angle and fully within the anterior chamber of the eye; wherein said polymeric body provides sufficient friction against tissue of the irido-corneal angle to hold the implant in position in the irido-corneal angle; and wherein said implant is configured to be deformed from a straightened to an arcuate shape for retention within the irido-corneal angle. - View Dependent Claims (27, 28, 29, 30, 31, 32)
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Specification