Compositions and methods to affect skin irritation

• US 10,245,283 B2
• Filed: 12/04/2017
• Issued: 04/02/2019
• Est. Priority Date: 12/28/2015
• Status: Active Grant

• Current Assignee: Alumend LLC, WavePharma LLC
• Original Assignee: Alumend LLC, WavePharma LLC
• Inventors: Utecht, Ronald E., Downey, Therese M., Seiberg, Miri, Shapiro, Stanley S., Foster, Jr., Jack V.
• Primary Examiner(s): Song, Jianfeng
• Application Number:
  US15/830,307
• Publication Number:
  US 20180092940A1
• Time in Patent Office: 484 Days
• CPC Class Codes: A61F 13/8405 Additives, e.g. for odour, disinfectant or pH control
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/75 Anti-irritant
• CPC Class Codes: A61K 2800/782 Enzyme inhibitors; Enzyme antagonists
• CPC Class Codes: A61K 31/05 Phenols cannabinoids A61K31/658
• CPC Class Codes: A61K 31/07 Retinol compounds, e.g. vitamin A retinoic acids A61K31/203
• CPC Class Codes: A61K 31/185 Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids hydroxamic acids A61K31/16; peroxy acids A61K31/327
• CPC Class Codes: A61K 31/203 Retinoic acids ; Salts thereof
• CPC Class Codes: A61K 31/722 Chitin, chitosan
• CPC Class Codes: A61K 31/737 Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate A61K31/727 takes precedence
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/671 Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
• CPC Class Codes: A61K 8/736 Chitin; Chitosan; Derivatives thereof
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61P 17/18 Antioxidants, e.g. antiradicals preparations for protection against sunlight A61Q17/00
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

Compositions are described that contain treated chitosan, modified chitosan and/or modified and treated chitosan for use in formulations for skin, hair and nails, and in compositions and methods of reducing topical agent-induced skin irritation and inflammation.

Claims

1. A sunscreen composition comprising:

(a) at least one sunscreen agent that causes skin irritation and/or skin inflammation and/or IL-1α

secretion, and (b) at least one chitosan covalently modified with an octane sulfonic acid via a sulfonamide linkage, wherein the composition provides a reduction in skin irritation and/or a reduction in skin inflammation and/or a reduction in irritant-induced IL-1α

secretion after contact with the composition compared with a control composition comprising the sunscreen agent but not the chitosan.

2. The composition of claim 1, wherein the at least one covalently modified chitosan comprises about 0.0001-5% W/V of the total weight of the composition.

3. The composition of claim 1, which is in the form of a solution, suspension, emulsion, lotion, cream, gel, or spray.