Ophthalmic composition
First Claim
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1. An eye care composition comprising:
- a. from about 10 ppm to about 1000 ppm of a polyquaternium compound having a weight average molecular weight of from about 150 to about 15,000 Daltons;
b. from about 0.001% to about 0.5% of an anionic polymer having a weight average molecular weight of from about 250 to about 4,000,000 Daltons; and
c. an effective amount of an organic acid, salts thereof or mixtures thereof, to achieve complete association of the organic acid with the polyquaternium compound such that the organic acid binds with the polyquaternium compound at at least a 1;
1 molar ratio;
wherein the composition is substantially free of cationic oligomer compounds and precipitation inhibiting compounds and wherein the composition is in the form of an eye-drop solution, an eye wash solution, or a solution, spray or mist for lubricating or rewetting a contact lens.
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Abstract
The present invention relates to ophthalmic compositions for treatment of conditions in the eye. More specifically, the present invention relates to ophthalmic compositions comprising a polyquaternium compound and an anionic polymer. Methods for reducing and/or preventing the incompatibility of polyquaternium compounds with anionic polymers are also disclosed.
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Citations
21 Claims
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1. An eye care composition comprising:
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a. from about 10 ppm to about 1000 ppm of a polyquaternium compound having a weight average molecular weight of from about 150 to about 15,000 Daltons; b. from about 0.001% to about 0.5% of an anionic polymer having a weight average molecular weight of from about 250 to about 4,000,000 Daltons; and c. an effective amount of an organic acid, salts thereof or mixtures thereof, to achieve complete association of the organic acid with the polyquaternium compound such that the organic acid binds with the polyquaternium compound at at least a 1;
1 molar ratio;wherein the composition is substantially free of cationic oligomer compounds and precipitation inhibiting compounds and wherein the composition is in the form of an eye-drop solution, an eye wash solution, or a solution, spray or mist for lubricating or rewetting a contact lens. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of reducing the precipitation of a polyquaternium compound and an anionic polymer in an eye composition comprising such compounds, comprising the steps of:
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i) providing from about 0.001% to about 0.5% of an anionic polymer having a weight average molecular weight of from about 250 to about 4,000,000 Daltons; ii) adding an effective amount of an organic acid, salts thereof or mixtures thereof, to achieve complete association of the organic acid with the polyquaternium compound such that the organic acid binds with the polyquaternium compound at at least a 1;
1 molar ratio; andiii) adding from about 10 ppm to about 1000 ppm of a polyquaternium compound having a weight average molecular weight of from about 150 to about 15,000 Daltons; wherein the composition is substantially free of cationic oligomer compounds and precipitation inhibiting compounds and wherein the composition is in the form of an eye-drop solution, an eye wash solution, or a solution, spray or mist for lubricating or rewetting a contact lens.
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Specification