Nanopatterned medical device with enhanced cellular interaction
First Claim
1. A medical device for delivering a drug compound through a stratum corneum and to a subdermal location, the device comprising:
- a support having an aperture;
an array of microneedles that extend outwardly from the support, wherein at least one microneedle contains a shaft that has an outer wall extending from the support to a tip, wherein the tip and at least a portion of the outer wall are configured to penetrate the stratum corneum, wherein a plurality of nanostructures are spaced about an external surface of the outer wall in a predetermined pattern, and wherein at least a portion of the nanostructures have a cross-sectional dimension of less than about 500 nanometers and greater than about 5 nanometers and an aspect ratio of from about 0.2 to about 5, wherein the microneedle contains a channel in a side of the microneedle, wherein the aperture is in at least partial alignment with the channel of the microneedle, wherein at least a portion of the microneedles has a cross-sectional dimension of from about 1 micrometer to about 1 millimeter; and
a reservoir wherein the drug compound is retained, the reservoir being in fluid communication with the channel of the microneedle for delivery to the subdermal location.
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Accused Products
Abstract
Disclosed are nanotopography-based methods and devices for interacting with a component of the dermal connective tissue. Devices include structures fabricated on a surface to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. Microneedles may be beneficially utilized for delivery of an agent to a cell or tissue. Devices may be utilized to directly or indirectly alter cell behavior through the interaction of a fabricated nanotopography with the plasma membrane of a cell and/or with an extracellular matrix component.
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Citations
35 Claims
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1. A medical device for delivering a drug compound through a stratum corneum and to a subdermal location, the device comprising:
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a support having an aperture; an array of microneedles that extend outwardly from the support, wherein at least one microneedle contains a shaft that has an outer wall extending from the support to a tip, wherein the tip and at least a portion of the outer wall are configured to penetrate the stratum corneum, wherein a plurality of nanostructures are spaced about an external surface of the outer wall in a predetermined pattern, and wherein at least a portion of the nanostructures have a cross-sectional dimension of less than about 500 nanometers and greater than about 5 nanometers and an aspect ratio of from about 0.2 to about 5, wherein the microneedle contains a channel in a side of the microneedle, wherein the aperture is in at least partial alignment with the channel of the microneedle, wherein at least a portion of the microneedles has a cross-sectional dimension of from about 1 micrometer to about 1 millimeter; and a reservoir wherein the drug compound is retained, the reservoir being in fluid communication with the channel of the microneedle for delivery to the subdermal location. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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Specification