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Calibration and detection of silicone oil in syringe barrels

  • US 10,247,679 B2
  • Filed: 10/14/2016
  • Issued: 04/02/2019
  • Est. Priority Date: 10/16/2015
  • Status: Active Grant
First Claim
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1. A method of calibration and detection of silicone oil in syringe barrels, comprising:

  • (a) providing a syringe barrel which has the inner surface coated with a silicone oil;

    (b) obtaining an image with an imaging system of the inner surface of the syringe barrel coated with the silicone oil, wherein the imaging system is capable of detecting silicone oil;

    (c) determining with a computer image analysis program executed by a computer a distribution pattern of the silicone oil at the inner surface from the obtained image;

    (d) determining by the computer image analysis program executed by the computer a comparison between (i) the distribution pattern of the silicone oil at the inner surface of the syringe barrel, with (ii) a calibration distribution pattern of an inner surface of a calibration syringe barrel coated with a cured silicone oil, wherein the silicone oil in the cured silicone oil is the same silicone oil as in the syringe barrel, wherein the calibration distribution pattern of the cured silicone oil is obtained from a calibration image obtained with the imaging system of the inner surface of calibration syringe barrel; and

    (e) outputting the comparison by the computer image analysis program executed by the computer.

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