Laser-induced ultrasonic wave apparatus and method

• US 10,251,559 B2
• Filed: 05/03/2013
• Issued: 04/09/2019
• Est. Priority Date: 05/03/2012
• Status: Active Grant

• Current Assignee: Samsung Electronics Co. Ltd.
• Original Assignee: Samsung Electronics Co. Ltd.
• Inventors: Kang, Sung-chan, Kim, Woon-bae, Kim, Jong-seok, Yoon, Yong-seop
• Primary Examiner(s): Carey, Michael
• Assistant Examiner(s): Ho, Don N
• Application Number:
  US13/886,792
• Publication Number:
  US 20130303909A1
• Time in Patent Office: 2,167 Days
• CPC Class Codes: A61B 5/0035 adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 8/4483 characterised by features of the ultrasound transducer
• CPC Class Codes: G01N 2291/02475 Tissue characterisation
• CPC Class Codes: G01N 29/2418 using optoacoustic interaction with the material, e.g. laser radiation, photoacoustics photoacoustic cells G01N21/1702; measuring characteristics of vibrations by using radiation-sensitive means G01H9/00; acousto-optical conversion techniques for short-range imaging G01S15/8965; sound-producing devices using laser bundle G10K15/046
• CPC Class Codes: G10K 15/046 using optical excitation, e.g. laser bundle

Abstract

Laser-induced ultrasonic wave apparatuses and methods of generating images using the same. The laser-induced ultrasonic wave apparatus includes a laser source which irradiates a laser beam to a target object and a thermoelastic material; a thermoelastic material which converts the laser beam to a first ultrasonic wave and irradiates the first ultrasonic wave to the target object; and a receiving unit which receives an echo acoustic wave of the first ultrasonic wave and receives a second ultrasonic wave generated by the target object due to the laser beam.

Claims

1. A laser-induced ultrasonic wave apparatus, the apparatus comprising:

a laser source configured to irradiate a target object and a thermoelastic material with a laser beam;

the thermoelastic material configured to be spatially apart from the target object, configured to generate a first acoustic wave based upon irradiation of the thermoelastic material by the laser beam, and configured to transmit the first acoustic wave to the target object;

a transducer configured to transduce acoustic waves into electric signals, the transducer including at least one piezoelectric micromachined ultrasonic transducer (pMUT), capacitive micromachined ultrasonic transducer (cMUT), or magnetic micromachined ultrasonic transducer (mMUT); and

a substrate between the thermoelastic material and the transducer in a single probe such that the single probe includes the thermoelastic material, the substrate, and the transducer,

wherein the transducer is further configured to

receive an echo acoustic wave of the first acoustic wave, as reflected from the target object through the substrate, and transduce the echo acoustic wave into first electric signals, and

receive a second acoustic wave generated in the target object by irradiation of the target object by the laser beam from the target object through the substrate and transduce the second acoustic wave into second electric signals.

2. The laser-induced ultrasonic wave apparatus of claim 1, further comprising:

at least one image processor configured to simultaneously generate a first image based upon the received second acoustic wave and a second image based upon the received echo acoustic wave;

wherein the at least one image processor is further configured to generate the first image as a photoacoustic image for functional analysis of the target object, and

wherein the at least one image processor is further configured to generate the second image as an anatomical image for acoustic analysis of at least the target object.

3. The laser-induced ultrasonic wave apparatus of claim 2, further comprising:

a user interface;

a display; and

a controller configured to control the at least one image processor to output at least one of the first image or the second image to the display based upon a user input detected by the user interface.

4. The laser-induced ultrasonic wave apparatus of claim 1, further comprising:

a controller configured to selectively change a pulse width of the laser beam based upon properties of the target object;

wherein the thermoelastic material is further configured to generate respective acoustic waves with different wavelengths based upon the selectively changed pulse width of the laser beam.

5. The laser-induced ultrasonic wave apparatus of claim 1, further comprising:

a controller configured to selectively change a pulse width of the laser beam based upon properties of the target object;

wherein the thermoelastic material is further configured to generate respective acoustic waves with different pressure magnitudes based upon the selectively changed pulse width of the laser beam.

6. The laser-induced ultrasonic wave apparatus of claim 1, further comprising:

a controller configured to selectively change a fluence of the laser beam based upon properties of the target object;

wherein the thermoelastic material is further configured to generate respective acoustic waves with different pressure magnitudes based upon the selectively changed fluence of the laser beam.

7. The laser-induced ultrasonic wave apparatus of claim 1, wherein the laser-induced ultrasonic wave apparatus is configured to split the laser beam into a first laser beam and a second laser beam that both maintain same characteristics as the laser beam, and

wherein the first laser beam is optically directed to irradiate at least a portion of the target object distinct from the second laser beam being optically directed to irradiate at least a portion of the thermoelastic material.

8. The laser-induced ultrasonic wave apparatus of claim 1, wherein the laser source simultaneously irradiates at least a portion of the target object with the laser beam and at least a portion of the thermoelastic material with the laser beam.

9. The laser-induced ultrasonic wave apparatus of claim 1, further comprising:

a controller configured to control the laser source to selectively irradiate only the target object with the laser beam during a first time period, and configured to irradiate only the thermoelastic material with the laser beam during a second time period;

wherein the first time period and the second time period are sequential in time and occur while the transducer is enabled to receive and transduce the echo acoustic wave and the second acoustic wave.

10. The laser-induced ultrasonic wave apparatus of claim 9, wherein the controller is further configured to controls the laser source to generate the laser beam to have respectively different characteristics during the first time period than during the second time period based upon properties of the target object.

11. The laser-induced ultrasonic wave apparatus of claim 1, further comprising:

a controller configured to selectively change characteristics of the laser beam to change a center frequency of the first acoustic wave generated by the thermoelastic material based upon properties of the target object.

12. The laser-induced ultrasonic wave apparatus of claim 1, wherein the thermoelastic material is selected so that an absorption rate of the target object is smaller than an absorption rate of the thermoelastic material.

13. The laser-induced ultrasonic wave apparatus of claim 1, wherein a pulse width of the laser beam is nano-sized or pico-sized.

14. The laser-induced ultrasonic wave apparatus of claim 1, wherein the thermoelastic material is formed of at least one of a metal, a semiconductor material, a carbon-based material, or a polymer material.

15. The laser-induced ultrasonic wave apparatus of claim 1, wherein the thermoelastic material is formed as a thin-film having a thickness less than respective wavelengths of the echo acoustic wave reflected from the target object and the second acoustic wave propagating from the target object.

16. The laser-induced ultrasonic wave apparatus of claim 1, wherein the thermoelastic material and the transducer are embodied together as the single probe.

17. The laser-induced ultrasonic wave apparatus of claim 16, wherein the thermoelastic material and the transducer are arranged in the single probe in a configuration so that when the laser beam is incident on the single probe, the thermoelastic material is enabled to be irradiated by the laser beam, and incidence of the laser beam on the transducer is minimized.

18. The laser-induced ultrasonic wave apparatus of claim 16, wherein the thermoelastic material and the transducer are arranged in the single probe so that the first acoustic wave generated by the thermoelastic material propagates through the transducer before propagating to the target object.

19. The laser-induced ultrasonic wave apparatus of claim 1, wherein the laser source is further configured to irradiate the target object and the thermoelastic material simultaneously with the laser beam.

20. The laser-induced ultrasonic wave apparatus of claim 1, further comprising:

a first signal processing processor configured to generate a first image based upon electric signals derived from the received echo acoustic wave;

a second signal processing processor configured to generate a second image based upon electric signals derived from the received second acoustic wave; and

an image combining processor configured to generate a third image by combining the first image and the second image.

21. A laser-induced ultrasonic wave method, the method comprising:

irradiating a target object and a thermoelastic material with a laser beam;

receiving and transducing, at a transducer configured to transduce acoustic waves into electric signals, an echo acoustic wave, from the target object, as a reflection of a first acoustic wave transmitted to the target object from the thermoelastic material upon the thermoelastic material being irradiated by the laser beam, the transducer including at least one piezoelectric micromachined ultrasonic transducer (pMUT), capacitive micromachined ultrasonic transducer (cMUT), or magnetic micromachined ultrasonic transducer (mMUT); and

receiving and transducing, at the transducer, a second acoustic wave generated in the target object upon the target object being irradiated by the laser beam from the target object,

wherein a substrate is between the thermoelastic material and the transducer in a single probe such that the single probe includes the thermoelastic material, the substrate, and the transducer and the echo acoustic wave and second acoustic wave are received by the transducer through the substrate, the single probe being separate from the target object such that the thermoelastic material is between the substrate and the target object, such that the laser beam, the first acoustic wave, and the second acoustic wave traverse through the substrate between the transducer and the thermoelastic material.

22. The laser-induced ultrasonic wave method of claim 21, further comprising simultaneously generating a first image based on the received second acoustic wave and a second image based on the received echo acoustic wave,

wherein the first image is generated to be a photoacoustic image for functional analysis of the target object and the second image is generated to be an anatomical image for acoustic analysis of at least the target object.

23. The laser-induced ultrasonic wave method of claim 22, further comprising selectively displaying at least one of the first image and the second image based upon a user input to a user interface.

24. The laser-induced ultrasonic wave method of claim 21, wherein the thermoelastic material is selected so that when the target object is a tissue within a human body, an absorption rate of the target object is smaller than an absorption rate of the thermoelastic material.

25. The laser-induced ultrasonic wave method of claim 21, wherein the thermoelastic material is formed as a thin-film having a thickness less than respective wavelengths of the echo acoustic wave and the second acoustic wave propagating from the target object.

26. The laser-induced ultrasonic wave method of claim 21, wherein the thermoelastic material and the transducer, performing the receiving of the echo acoustic wave and the second acoustic wave, are embodied together as a single probe element.

27. The laser-induced ultrasonic wave method of claim 21, wherein the target object and the thermoelastic material are simultaneously irradiated with the laser beam.

28. The laser-induced ultrasonic wave method of claim 21, further comprising:

generating a first image based on electric signals derived from the received echo acoustic wave;

generating a second image based on electric signals derived from the received second acoustic wave; and

generating a third image by combining the first image and the second image.